Investors' Room :: PROTHERICS - MoneyAM - Free Share Prices, Stock Quotes, Charts, News, Level2

WHITESTAR001 - 10 Feb 2006 15:08

THIS SHARE WILL BE WORTH 3.00 IN 2009

bristlelad - 10 Feb 2006 18:17 - 2 of 309

HI WHITESTAROOI///THIS SHARE IS WORTH 3 NOW ///BUT IT ONLY COST 1?????

transco - 22 Mar 2006 20:08 - 3 of 309

could not agree more - nothing goes up in a direct line - profit taking was bound to happen - buy on dips - sel on peaks - but keep hold of a large chunk cos this will fly any any snipet of further good news (im a long term holder)

queen1 - 22 Mar 2006 22:44 - 4 of 309

Why 3 WHITESTAR001, and why 2009?

transco - 04 Apr 2006 10:41 - 5 of 309

Get ready for the next move upwards - could be dramatic!!

queen1 - 04 Apr 2006 12:19 - 6 of 309

Why transco, and why now?

transco01 - 04 Apr 2006 12:45 - 7 of 309

read the company reports - early 2006 new milestones being reached plus......

greekman - 04 Apr 2006 17:00 - 8 of 309

Axa have reduced their holdings by 807,400 shares. Could be down to a bit of re-shuffling end of year, as they still hold over 31 million. But not a good sign.

transco - 04 Apr 2006 22:00 - 9 of 309

Greekman - Sorry but thats rubbish (not a good sign).
Its no sign at all - this baby is about to gather steeeeeeeeeeem....
long tem holder - look at previous posts...
Patience will reward us all....

greekman - 05 Apr 2006 08:31 - 10 of 309

Transco Hi,

It's no big deal. As I said they still have 31 mill. Okay it probably is as you say more of a no sign. It may be that Axa needed to release a bit of cash for a client. Like you a long term holder of a company with a great management team, and a good solid base of products. I expect this companies shares to rocket over the next 18 to 24 months.

transco - 05 Apr 2006 17:44 - 11 of 309

Hi Greekman,

No probs .. I have held for years. At long last I'm sure the pipeline
holds at least one blockbuster.
There are risks but everything in life is....

greekman - 06 Apr 2006 07:46 - 12 of 309

Pre-close Trading Statement.

Looks like they had some problems over the year re CroFabTM, but they remain confident that the implementation of the planned CroFabTM manufacturing changes will significantly improve margins over the medium term. Teething troubles, no doubt. The overall prospects for PTI with the cash position ( at present ) and the steady stream due from CroFabTM and their other products make this company look a very good investment.
I think the market will be jittery, due to many expecting the pot of gold tomorrow. But as said medium to long term, great prospects.

transco - 06 Apr 2006 11:15 - 13 of 309

Dont worry about the problems - they are small beer and maybe give one last chance to top your holding up under a quid......

greekman - 06 Apr 2006 11:23 - 14 of 309

Transco,
Agreed, not worried. Looking ahead.

greekman - 07 Apr 2006 08:03 - 15 of 309

Tipped in the Indie and the Times today.

Nice write ups. See links.http://news.independent.co.uk/business/analysis_and_features/article356310.ece

http://www.timesonline.co.uk/newspaper/0,,174-2122766,00.html

transco - 07 Apr 2006 08:06 - 16 of 309

Geekman - Nice one - keep the faith......

greekman - 07 Apr 2006 08:50 - 17 of 309

For those that have read the Indie link, it states re CroFab 'Analysts believe it could be worth up to $8bn (4bn)'.
With royalty payments of 20%, that is 800,mil. If their predictions are correct, what price the sp then.

transco - 07 Apr 2006 10:22 - 18 of 309

Nice pop today on press news - Unfortunately in my experience this normally
brings a pullback for those who knew it was comming. Expect it to come back to 84p min.
Not to worry though the fund managers wont be on the sidelines for much longer.

greekman - 07 Apr 2006 20:19 - 19 of 309

On low volume the closing sp was nicely up. The press reports did not tempt the punters. I wonder if Monday will show an L or OT trade for a large buy.

lukeman - 07 Apr 2006 23:39 - 20 of 309

greekman and transco, thanks for the ongoing commentary which, to be honest, has influenced my decisions while adding to spread holdings. No pressure! My tree analysis on Protherics continues to give only one answer which seems to be a binary "buy" though yesterday was painful. Will continue to have a ridiculous weighting in this stock and add while it is under 1.

greekman - 13 Apr 2006 12:12 - 21 of 309

Suddenly a move at 1150 by all the mm's ( 9 ) that deal in this share. All moved on bid and ask. All this on low volume.
Why are they all suddenly competing with each other. Is something about to break.

transco - 19 Apr 2006 15:30 - 22 of 309

Another nice move - news soon me thinks...

greekman - 27 Apr 2006 15:48 - 23 of 309

So it looks like Artimis Investment have increased their holdings according to my records. This is the last holding notification regarding Artimis.

The Company was informed by Artemis Investment Management Ltd. on 14 February 2005 that, following a sale of shares, Artemis Income no longer has a notifiable interest of shares in the Company.

greekman - 15 May 2006 07:37 - 24 of 309

Astrazeneca, are according to the weekend press looking for more tie-ups or licensing deals. They have even created a high level post, with sole responsibility to search for such deals. The main company mentioned in the article was the licensing deal with Protherics. Could they return looking for more. Even if not it was a nice little bit of publicity.

greekman - 16 May 2006 11:02 - 25 of 309

Re RNS
M&G Investment Management Limited , Prudential plc and certain of its subsidiary companies held a notifiable interest in 10,431,716. This is an increase from the 9,873,542 held on 25/01/06. Good to see the institutions increasing their holdings especially the way the stock market is lately.

queen1 - 16 May 2006 13:46 - 26 of 309

Yes, it does show confidence in PTI which is especially engouraging bearing in mind the way the sp has stagnated of late.

transco - 16 May 2006 20:07 - 27 of 309

Queen1,

Stagnation? - take a longer view chum. The chart is as positive a chart than i have seen this side on Christmas. Give it more time and the rewards will come.

queen1 - 17 May 2006 09:54 - 28 of 309

It's moved sideways and down since I bought in "chum".

transco - 17 May 2006 11:06 - 29 of 309

mmm so that was at most a month ago - come on be serious.
3 months view is a gamble - look 3 years ahead and you will make real money.

queen1 - 17 May 2006 14:30 - 30 of 309

It was earlier than that but I'm in to make money so sitting tight.

greekman - 01 Jun 2006 16:40 - 31 of 309

Snakebite-serum firm on growth trail May 31 2006

David Williamson, Western Mail

SNAKEBITE serum manufacturer Protherics is preparing for global growth through a programme to help its managers identify weak links in their chain of command.

http://icwales.icnetwork.co.uk/0300business/0100news/tm_objectid=17150939&method=full&siteid=50082&headline=snakebite-serum-firm-on-growth-trail-name_page.html

greekman - 07 Jun 2006 07:59 - 32 of 309

Results as expected, and the next 2 to 3 year prospects look very good indeed.

Strong cash position at end of period of 25.4 million (2005: 7.3 million), following CytoFab(TM) upfront payment and equity contribution from AstraZeneca.

If you dig out the cash facts after all the ins and outs of R+D, acquisitions, investments etc, this paragraph reads well, and just about sums up the cash position.

Cash inflow from operating activities was 12.6 million compared to an outflow
of 2.8 million in the prior year. Although the operating loss for the year was
9.5 million, only 0.7 million of the initial 16.3 million non refundable
receipt from AstraZeneca was recognised as income in the period, and this is
reflected in the increased cash inflow from operations.

I think this may make the market sit up and take a bit more notice. There is a good indication in these results of things to come.

greekman - 07 Jun 2006 17:18 - 33 of 309

Well the market appears to like it, at 5.25p ( 6.35 ) up on a relatively good turnover of 1.93 million shares traded. This leads me to believe that institutional investment is about to increase.

transco - 07 Jun 2006 19:04 - 34 of 309

Greekman - Looking good eh.
This one is a winner plenty more in the pipeline too.
Must be worth another 50p or so dont you think?

greekman - 08 Jun 2006 07:42 - 35 of 309

Hi Transco,

Nice of someone to join me, I was getting a bit lonely out here. Yes I think we will see the share price at nearer 2 within 12 to 18 months as long as there are no big hiccups along the way. I don't usually state any opinion or prediction re future share price as it nearly always comes out as a ramp/deramp but I think the prospects are endless for PTI if we are patient and look many year ahead. As we know drugs can be a very up and down business, as the larger companies often tell us. For it's size PTI must be the best such type of company around, with a very good product line and a management that knows what it's all about.

greekman - 08 Jun 2006 08:03 - 36 of 309

A nice snippet from Motley Fool.

A Tempting Biotech Bet
By Ed Bowsher (TMFArkle)
June 7, 2006

I think it's a good time to look at one of the UK's better biotech companies -- Protherics (LSE: PTI). I'm not saying that Protherics is an inevitable bid target, but I do think it looks undervalued. The most exciting product in the company's portfolio is a drug for severe sepsis called Cytofab.

http://www.fool.co.uk/news/comment/2006/c060607f.htm?ref=foolwatch

bristlelad - 08 Jun 2006 21:47 - 37 of 309

HI greekman/ I THINK THAT IF YOU READ THAT NOTE CORRECTLY ?ITS POINT TO A FOUR YEAR LIFESPAN TO COME RIGHT////

greekman - 09 Jun 2006 07:26 - 38 of 309

Hi Bristlelad,

Yes, had seen the 4 year bit, but with PTI's list of products at their relevant stages, and with the bigger companies such as AstraZeneca sniffing around that's what make me ( possibly a bit rash ) go for the 2 sp in 12 to 18 months.
My bit " but I think the prospects are endless for PTI if we are patient and look many year ahead " is looking at the 4 year plus note. But who knows.

greekman - 09 Jun 2006 13:04 - 39 of 309

The Daily Telegraph quote David Brennan Chief Exec of AstraZeneca as stating they will look to further acquisitions to bolster its drugs pipeline. They are mostly interested in areas were they have a substantial presence. I can see a move for PTI. I hope they do stay independent for the reasons already mentioned re the next few years prospects, but if the offer is good enough who knows. Money talks and AZ have plenty of it.

greekman - 20 Jun 2006 11:18 - 40 of 309

Piper Jaffray to Host First Ever London Health Care Conference
Monday June 19, 1:00 am ET

Companies scheduled to present and attend the London Health Care Conference include: Protherics Plc,
Ok there are many companies presenting, but any such appearances can only do companies such as those with PTI's innovative products good. Will be nice to see what interest the media show after the event.

LuckyMutley - 20 Jun 2006 20:13 - 41 of 309

Hi!

I am a newcomer to this site-very interested to see the postings re Protherics-what do seasoned members think of Alizyme?

greekman - 22 Jun 2006 09:14 - 42 of 309

Protherics gives CoVaccine's novel adjuvant a shot
By Gregory Roumeliotis.

21/06/2006 - Biopharmaceutical firm Protherics has acquired a new adjuvant from Dutch company CoVaccine that it will use for its hypertension vaccine, hoping to boost antibody production by tenfold.

http://www.in-pharmatechnologist.com/news/ng.asp?n=68578-protherics-angiotensin-covaccine-adjuvant

greekman - 28 Jun 2006 16:45 - 43 of 309

Very strange, or is it.

Eight what look like test trades go through as buys, totaling 494 shares, then 2 x 1,450,000, out of hour trades mid range go through. Will be interesting to see what they open at tomorrow.

greekman - 29 Jun 2006 10:20 - 44 of 309

Opened 1.5p higher, and climbed slightly since. Looks like they were buy's.

queen1 - 29 Jun 2006 20:14 - 45 of 309

Not quite as exciting as it could have been though greekman, especially given the positive nature of today's markets.

greekman - 30 Jun 2006 06:52 - 46 of 309

It looks as if your right. No doubt, unless bad news comes prior to opening today, most shares will open up due to the Dow's close of 217 up. Strange that thing called market sentiment.

queen1 - 30 Jun 2006 22:13 - 47 of 309

Indeed it is. Pity PTI wasn't able to rise again today.

greekman - 30 Jun 2006 22:33 - 48 of 309

Yes, well that's the way the cookie crumbles ( strange saying, I wonder where it came from ). Well have a good week-end. Night follows day and every cloud etc. Rambling now. Could be old age, the bottle of vino, or both.
Cheers greek.

queen1 - 30 Jun 2006 22:41 - 49 of 309

Cheers to you too greek. Don't let the bed bugs bite!

greekman - 22 Sep 2006 09:22 - 50 of 309

Another nice rise as at 0900hrs, following on from yesterdays positive move.
Something tells me that within the next couple of trading day we will see an RNS re an institution buying, with some delayed buys showing. The mms appear to be tempting sellers perhaps in order to fill an order. All imho of course.
Whatever the reason for the rise, it is looking good.

transco - 22 Sep 2006 20:37 - 51 of 309

looking gooood!

queen1 - 23 Sep 2006 13:45 - 52 of 309

Yes, a good week. More to come?

greekman - 26 Sep 2006 17:08 - 53 of 309

Looks like M@G have increased their holdings.
On 26/09/06 holdings notified at 10,431,716.
On 25/01/06 holdings notified at 9,873,542.
So a nice increase of 558,174.

greekman - 02 Oct 2006 09:09 - 54 of 309

Anyone know whats happening.
Prior to 0853 there was only one small trade, a buy of 300 shares.
Since then a rush of buys, and up 3p. OK only 157,000 in total but strange but 18 buys in 8 mins! Could of course be people turning up at work and getting on line, but to my knowledge this does not usually happen, when no news.

greekman - 02 Oct 2006 10:58 - 55 of 309

Now up 3.75p ?

greekman - 19 Oct 2006 09:41 - 56 of 309

Post in error

greekman - 03 Nov 2006 07:27 - 57 of 309

From strength to strength.

AstraZeneca Updates CytoFab(TM) Development Programme.

The Phase II programme will start in the second half of 2007 and is expected to
last up to 21 months. It will be immediately followed by the initiation of the
Phase III study in the US, EU and Japan.

Looking good. The mid to end of 2009 is quit a long way off, but in the drug business it's not too long to wait. Also don't forget PTI's other products in their pipeline.

hlyeo98 - 03 Nov 2006 08:13 - 58 of 309

More delays now...argh

Protherics PLC
03 November 2006

Protherics PLC

AstraZeneca Updates CytoFab(TM) Development Programme

London, UK; Brentwood, TN, US; 3 November 2006 - Protherics PLC ('Protherics' or
the 'Company') and AstraZeneca today announce AstraZeneca's intention to expand
the development plan for CytoFab(TM), a treatment for severe sepsis, with the
addition of a 480 - patient Phase II study programme.

AstraZeneca has recently completed consultations with regulators in the US and
EU. These consultations confirmed that a single Phase III study could be
sufficient for regulatory approval. Furthermore, to meet the regulatory needs
of both agencies, it is required that AstraZeneca implement a Phase II study
programme to support the single global Phase III study.

Data from Phase II will be used to more accurately estimate the number of
patients required, and confirm the appropriate dose for the Phase III study, as
well as providing further supporting efficacy and safety data. This may enable a
shorter timetable for the Phase III programme than originally anticipated by
AstraZeneca.

The Phase II programme will start in the second half of 2007 and is expected to
last up to 21 months. It will be immediately followed by the initiation of the
Phase III study in the US, EU and Japan.

Under the terms of the licensing agreement, AstraZeneca is responsible for
conducting and funding the global development of CytoFab(TM) and Protherics is
responsible for product supply.

John Rex, Vice-President, Medical Director for Infection, AstraZeneca, said:

'Our goal is to optimise the chances of showing a statistically and clinically
meaningful result with CytoFab(TM), in a single, global Phase III study, while
ensuring an acceptable time to market. To increase the likelihood of success in
this complex disease and reflecting the changing regulatory environment for
biologics, we have made the decision to undertake additional clinical work. We
hope that this will help to reduce the size of and the time needed to complete
the Phase III study. We believe that this development plan will give us the best
chance of successful registration for this exciting treatment.'

Andrew Heath, Chief Executive of Protherics, said:

'CytoFab(TM) represents a major market opportunity and AstraZeneca's proposed
development programme provides the treatment with the best route to
registration. We now have a clear view of the steps needed to make this
important new treatment available to sepsis patients worldwide.'

| Ends |

greekman - 03 Nov 2006 11:49 - 59 of 309

Opened lower as the MM's knew that most punters would look at it as more delay, but it's not bad news. The drug industry is not a get rich today, tomorrow or even next year.
Patience is the key. Protherics must be one of the best up and coming companies in it's field. If things progress as expected, todays sp will be looked back on as a fantastic bargain. It also as stated has other products progressing nicely.

Following is an extract from a Market-wire. CytoFab, Voraxase, Prolarix, CroFab, (pit viper antivenom) and DigiFab are also mentioned.

CytoFab is a first in class anti-TNF-alpha polyclonal antibody fragment (Fab) product, which is being developed for the treatment of severe sepsis.

The most advanced products in the Company's portfolio are Voraxaze, which is expected to be approved in the US and EU in 2007, subject to regulatory reviews, as an intervention when methotrexate blood levels remain dangerously high following high doses for the treatment of cancer and CytoFab, which is being developed by AstraZeneca, initially for severe sepsis, and is expected to start an additional Phase II study in 2007.

See link for full article, it's well worth a read to reiterate what a forward looking company Protherics is.

If I had spare cash, I would be looking at this drop in the sp as a buy opportunity.

http://www.marketwire.com/mw/release_html_b1?release_id=180059

bristlelad - 03 Nov 2006 12:52 - 60 of 309

Iam glad that Iam not the only person who has overspent on s.e.o so have no money left to buy these at this price /Ihope we have done the right thing///

greekman - 07 Nov 2006 09:20 - 61 of 309

Protherics to resubmit its Voraxaze(TM) BLA following FDA data request.
Still looking good for Voraxaze, but any delay is bad news even if it appears to be only 6 months (a small time in the drug world).
This looks worse than it is probably due to being on the back of the previous RNS.
Shares look a good buy at this price, as long as a term of at least 1 to 2 years is being looked at.

hlyeo98 - 07 Nov 2006 09:22 - 62 of 309

There will be further downtrend in the short term...IMO to 60p

hlyeo98 - 07 Nov 2006 16:10 - 63 of 309

Chart.aspx?Provider=EODIntra&Code=PTI&Si

greekman - 07 Nov 2006 16:24 - 64 of 309

Hlyeo,

Could be right but I think the drop has been overdone, they usually are.
I expect it to end the week still down but with some recovery.

queen1 - 07 Nov 2006 19:55 - 65 of 309

The drop has been well overdone. We're in the same place we were this time yeasterday, just 6 months further away. Not a justification for such a large drop. This will definately bounce back.

hlyeo98 - 08 Nov 2006 00:13 - 66 of 309

but delays in product coming onto the market means loss of income. I think it will go lower.

greekman - 08 Nov 2006 07:30 - 67 of 309

Agree it means income coming in later (about 6 months) but if you look at the whole picture, did this delay warrant a drop of that percentage.
They have other products already producing income. Their financial situation is also good. They have a good R+D set up, excellent management and a health product line.

kimoldfield - 08 Nov 2006 08:08 - 68 of 309

The Independent has Protherics as a buy

"Investors should use the recent weakness in Protherics stock, due to delays two drugs under development, as a buying opportunity.The company is among the most well-financed in the biotechnology sector. While via CytoFab, it, and partner AstraZeneca, pretty much have the 4bn sepsis market to themselves."

greekman - 08 Nov 2006 08:16 - 69 of 309

Hi Kim,

Nice little write up. Says it all really.
The way this day has started looks like punters are doing just that (a buying opportunity.).

kimoldfield - 08 Nov 2006 08:27 - 70 of 309

Hi GM, I'm hoping this won't be as stressful as SEO!!!
kim

greekman - 08 Nov 2006 08:53 - 71 of 309

Kim,

I would think that would be impossible, ( I hope).

queen1 - 08 Nov 2006 22:19 - 72 of 309

Well there was a bounce today as I predicted. More to come tomorrow?

greekman - 17 Nov 2006 07:37 - 73 of 309

http://www.cnw.ca/fr/releases/archive/November2006/16/c5550.html

Scrip Awards
LONDON, Nov. 16 /CNW/ - "It is only the second year, but the world now
has Scrip Awards written on its heart 600-plus international guests attended the second Scrip Awards ceremony, held at the Grosvenor House Hotel in London.

Well we all thought it was a good deal between Protherics and AstraZeneca, now it looks better than ever. This lot presumably know what they are on about.
Anything such as this bring PTI more into the public but mainly the private eye view of the pharmaceutical industry.
All the big names were obviously there. It must me like the Oscar Awards for the drug industry.
The whole article is not very interesting but if you want a look, see link.

Licensing Deal of the Year
Sponsored by Imperial Innovations
Winner - Protherics and AstraZeneca
For those who remember the deal was announced on 8th December 2005.

queen1 - 17 Nov 2006 12:30 - 74 of 309

A ringing endorsement greekman. Let's hope this helps to settle investors nerves that have been jangling a little over the past fortnight.

greekman - 17 Nov 2006 13:09 - 75 of 309

Hi Q,

I think it will as it already appears to have calmed down somewhat.
No matter what the share there are always those interested in a quick buck (me included), but Protherics is one to put away for 1 to 3 years.
Obviously in the drug business, as we know no matter how well trials are going, it can go wrong at the last hurdle.

queen1 - 17 Nov 2006 20:23 - 76 of 309

Indeed. But like you I'm squirreling away for that sunny day :-)

greekman - 27 Nov 2006 07:33 - 77 of 309

RNS with excellent news.
It looks like DigiFabTM is a great improvement on Roche's Digitalis Antidote(R).
Also with a nice close working relationship with Roche, it makes an even more viable future for PTI. Roche AND AstraZeneca.
Protherics is now really playing with the big boys.

petralva - 27 Nov 2006 08:33 - 78 of 309

Protherics PLC
27 November 2006

Protherics PLC

Protherics' DigiFabTM to replace Digitalis Antidot(R) in Europe

London, UK; Brentwood, TN, US: 27 November 2006 - Protherics PLC ('Protherics'
or the 'Company'), the international biopharmaceutical company focused on
critical care and cancer, today announces the transfer of market rights for
Digitalis Antidot(R) from Roche to Protherics, with the intention of replacing
Roche's Digitalis Antidot(R) in the market with Protherics' own digitalis
antidote DigiFabTM from early 2007.

Roche's Digitalis Antidot(R) is currently approved in France, Germany and
Switzerland. Protherics has acquired the market rights for Digitalis Antidot(R)
for a small undisclosed cash consideration, and is working with Roche to
facilitate the smooth transition in the market from Digitalis Antidot(R) to
DigiFabTM.

DigiFabTM is an ovine derived Fab preparation for the treatment of digoxin
toxicity which can have severe effects on the heart and central nervous system,
sometimes leading to death. It is currently licensed by the US Food and Drug
Administration for the treatment of patients with life-threatening or
potentially life-threatening digoxin toxicity or overdose. Marketing
authorisation will be sought in major European countries, including France,
Germany, Spain and Italy, following grant of approval in the UK, expected early
in 2007. Protherics will continue to make DigiFabTM available on a named
patient basis.

DigiFabTM will be marketed in most mainland European countries by Protherics'
licensee, Beacon Pharmaceuticals. Protherics will be directly responsible for
marketing and sales in Germany, one of the major European markets, as well as in
the Nordic countries.

Andrew Heath, Chief Executive of Protherics said:

'Protherics' goal is to become the global market leader in the anti-digoxin
antibody market. We are pleased to be co-operating with Roche in arranging for
a smooth market transition from Digitalis Antidot(R) to DigiFabTM in order to
ensure continued patient care for this potentially life-threatening condition.'

Eugene Tierney, Business Director at Roche said:

'Roche has been looking for a company that can take over its digitalis antidote
business, to ensure that it remains available for patients to treat
intoxication. We are pleased that Protherics, a company experienced in that
business, will be supplying the market.'

For further information please contact:

Protherics
Andrew Heath, CEO +44 (0) 20 7246 9950
Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510
Saul Komisar, President Protherics Inc +1 615 327 1027

Financial Dynamics - press enquiries
London: Ben Atwell, David Yates, Anna Keeble +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt +1 212 850 5600

greekman - 27 Nov 2006 09:22 - 79 of 309

I know it's still early, but I would have expected the sp to have moved up at least 5p on the news, especially after its dip that was overdone a couple of weeks ago.
I am sure the institutions will be buying this week.
Unfortunately, no spare cash to top up.
I wonder if Astrazeneca and Roche will view Protherics as an even more R+D productive target.
The competition in the pharmaceutical world is strong. If one company gets any inkling of the other sniffing around, you never know.
I am a strong believer in PTI as a future strong player in its field.
I hope that they stay independent.
But due to consolidation in the drugs market, you never know.

greekman - 29 Nov 2006 09:29 - 80 of 309

Finally decided to buy more after selling a far more risky share.
(Now watch this dip and my sell PET fly).
Looking to the mid to long term on this as PTI is a very solid, cash secure company with exciting, products and R+D base.

greekman - 30 Nov 2006 16:40 - 81 of 309

Typical, I increase my holdings and the following day a big drop for no apparent reason.
Good job I don't tip horses.
Only comfort is the whole sector is well down.

greekman - 30 Nov 2006 16:51 - 82 of 309

Aviva plc now hold 31,441,191 ordinary shares.
This notification follows the purchase of 105,500 ordinary shares on 27 November
2006 representing 0.04% of the issued share capital of the Company.
Always nice to see the institutions buying.

hlyeo98 - 30 Nov 2006 18:03 - 83 of 309

3p down today to 64p...don't look good now...on the sharp decline slope.

greekman - 05 Dec 2006 08:51 - 84 of 309

For full article see link.
Could see several smaller biotechnology companies, taken over in the next year.
Hopefully PTI will be looked at for more dual licencing, and not a takeover.

The Times December 05, 2006
Big hole in development pipeline
Robin Pagnamenta: Analysis

Pfizers pipeline was already viewed as weak, but the company now has little choice but to use some of its $17 billion cash pile to acquire other companies and potential drug candidates.

However, competition is likely to be intense as several other big drug groups are facing similar problems at the moment. AstraZeneca, GlaxoSmithKline and others are keen to make acquisitions and are paying big premiums for interesting biotechnology companies.

http://www.timesonline.co.uk/newspaper/0,,2740-2487079,00.html.

Whichever way it goes it's good news for companies like PTI.

greekman - 07 Dec 2006 07:56 - 85 of 309

Results out.

Apart from the odd hiccup, which investors in companies such as Protherics, should expect, the future looks very rosy indeed.

Three agreements to expand its development pipeline in its core franchises of critical care and cancer. Placing and Open Offer (the 'Placing and Open Offer'), at an issue price of 65 pence per share.
The Overview of the Transactions, looks good, lets hope the offer is nicely priced.
Revenue increased slightly. R@D increased vastly.
Strong cash position at end of period of 17.9 million.
Soon know how the market looks at it. The institutions may bide their time or step in prior to any placing. Would be nice to see them increase their holdings via the placing and before.

greekman - 07 Dec 2006 09:56 - 86 of 309

Re the cash call.

Whenever I see a company looking for further funding, I pay great detail to the reason.
If it is just to keep the company afloat, then usually it's a bad call.
Protherics are cash sound, so any increased funding in those circumstances is for a sound reason. It is not required for survival.
In my opinion, this cash call is for a very good reason, increased R@D and to push production and sales of existing products.
PTI have a very good product base already earning. They also have an excellent cache of products in varying stages of development, many being fated by the big companies that are looking to increase their product base.
The cash call IS fairly large with a proposed share issue of about 1 fifth of the total shares already in issue.
This to me says they are looking at a bigger picture of development for the next 2 to 5 years.
Yes, of course the shares will be diluted, but if the issue is set to us private investors at a good offer ratio, it may not drop the sp too much, after of course allowing for the dilution sp reduction.
Protherics management has shown consistently good management skills for many years now and as a holder of this share for a considerable time, I have faith in their decisions.
This faith is not blind, it is there because they have given me no reasons to doubt. I doubt that they will be looking at further calls for 2007-2008, as they have presumably judged the amount required with this call to see them through at least the next 2 to 3 years.
I am looking at a steady sp for the coming year.
I am then looking at a steady climbing sp at end 2007, into 2008.
The above is obviously my opinion, so could be totally wrong.
Greek.

queen1 - 07 Dec 2006 13:05 - 87 of 309

Seems sound to me greekman.

greekman - 07 Dec 2006 14:53 - 88 of 309

Queen1,

Lets hope the market over the next few weeks takes the same view as we have.

transco - 07 Dec 2006 20:35 - 89 of 309

Greekman - I hope you are right I am losing my nerve.
I wil support the new shares - lets face it 65p must be rock bottom but I am getting scared. Keep the fath.

queen1 - 08 Dec 2006 13:59 - 90 of 309

Hang inthere transco. Fortune favours the brave, and all the jazz!

greekman - 08 Dec 2006 14:08 - 91 of 309

Hope I am not jinxing the sp but with an increase of 3.99% on an average volume, against a sector increase of .03%, there may be another after market close release re institutional buying. Can't see any other reason for it to be climbing.

greekman - 08 Dec 2006 14:26 - 92 of 309

In the cash call statement it stated that one of the reasons was a "Proposed In-licensing of intellectual property from Glenveigh
Pharmaceuticals LLC".

Note the word PROPOSED.

In an article released 2:57 PM CST Thursday in The Nashville Business Journal it states.

The company also has signed licensing deals with Glenveigh Pharmaceuticals, a North Carolina company that focuses on pregnancy-related drugs, and Advanced In Vitro Cell Technologies (AdvanCell), a company headquartered in Spain that develops cancer drugs.

Note. HAS SIGNED.

Maybe this is just a play on words by T N J, but I am wondering if this is part of the reason for the sp rise.
For the full article see link.

http://charlotte.bizjournals.com/nashville/stories/2006/12/04/daily29.html

greekman - 11 Dec 2006 10:08 - 93 of 309

A good 5 minute read. It shows the way the big drug conglomerates are courting the small bio companies.
Protherics is not mentioned, but must be up there in the sights of those multi million companies.
Licencing deals look the way forward.

Large pharmaceutical companies piggyback onto research, risk By Stephen Pounds
Palm Beach Post Staff Writer
Sunday, December 10, 2006.

"The big pharmaceutical companies recognize that biotechs are more willing to take risks and do research in areas that are more on the edge of science," said Jim Greenwood, president of the Washington, D.C.-based Biotechnology Industry Organization.

While Big Pharma's own drug discovery dwindles, investors in these behemoth companies worry about where sales will come from when a locker full of major medicines loses patent protection. Once the patents expire, drugs are quickly copied for generic sale by companies such as Miami's Ivax Corp., recently acquired by Israel's Teva Pharmaceutical Industries.

And it's not just Pfizer. Merck & Co.'s Fosamax, its $3 billion treatment for slowing bone loss, comes off patent in 2008; Singulair, the $3 billion drug for controlling chronic asthma, in 2010. Bristol-Myers Squibb loses the anti-clotting drug Plavix, the second largest-selling drug globally, in 2011. And Eli Lilly & Co. will lose exclusivity for Zyprexa, a schizophrenia drug worth $4 billion in annual sales, that same year, said Arthur Wong, an analyst with Standard & Poor's.

That's why Big Pharma mainly targets biotech companies, which have garnered a reputation for nimble scientific discovery.

For full article see link.

http://www.palmbeachpost.com/business/content/business/epaper/2006/12/10/a1f_bigpharma_1210.html

transco - 18 Dec 2006 15:43 - 94 of 309

Just sent off a large cheque to take up my rights - I hope we come good!!

greekman - 19 Dec 2006 16:27 - 95 of 309

More sells than buys, on a narrow spread and up 3.25p (4.3%) against the sector (down around 4%). Someone accumulating for an institution increase perhaps.
Can't read anything else into Level 2.

greekman - 20 Dec 2006 11:39 - 96 of 309

PTI tipped in Money Observer supplement '2007 Wealth Creation Guide'. Under 'Shares Tipped For Big Gains in 2007' Mark Barnett of Invesco Perpetual says:-

"Protherics (PTI) 69p - This small biotech firm has seen share price falls due to delays in pipeline products. But a tie-up with AstraZeneca is worth the entire market capitalisation alone, so the rest of the business is being offered for zero value"

Let's hope he is right.

greekman - 22 Dec 2006 08:58 - 97 of 309

Well thats it for me pre Xmas, off out.
Merry Xmas to all.
Greek.

queen1 - 22 Dec 2006 12:05 - 98 of 309

Merry Xmas greekman.

transco15 - 26 Dec 2006 09:16 - 99 of 309

Mrry Christmas everyone lets hope 2007 is the year for Protherics its taken a long long time but we are looking good at long last.
I hope everyone went for the offer?

greekman - 05 Jan 2007 15:48 - 100 of 309

Level 2 looking good for a strong finish.
Order book showing buys to sells 2 to 1.
The spread is very minuscule, in fact as I type it was nil for a mili second.
Volume better than average but nothing fantastic.
Perhaps its the usual ( someone knows something us PI's don't).
A big buy order to fill perhaps!!!!!

transco15 - 07 Jan 2007 13:51 - 101 of 309

No I think its just press comment on the cancer drug.
Although a cure for cancer would be something for now I would be happy with a bit of share price stability.
The offer didnt go that good with only 80% take up I wonder what the usual take up is for a similar offer??? Anyone has any idea?
Big day monday me thinks.

greekman - 08 Jan 2007 09:01 - 102 of 309

Transco,

I feel the offer went well considering the timing (Xmas and all that), and have no doubt the institutions will eagerly take up any slack.
Looks like the RNS re Digifab will keep this share up, although it was expected.

greekman - 11 Jan 2007 07:33 - 103 of 309

Well after the re submitting of Voraxaze license application to the US, it was probably a forgone conclusion that the same would be required to Europe (don't we always follow). So on the whole it has to be taken as good news. The US have excepted the fast tracking principal and again presumably Europe will follow.
I was surprised the other day to find that the FDA in 2006 only authorized the full licencing of 15 prescription drugs, their lowest ever. It shows how the drug licencing authorities are toughening up. Its the US follow my lead that to me looks very very promising. Protherics imho looks an even better medium to long term prospect.

greekman - 25 Jan 2007 08:44 - 104 of 309

The new appointment of Dr Jacques Gonella, looks a good move.
Looking at his CV he has plenty of contacts and experience.

greekman - 25 Jan 2007 08:44 - 105 of 309

Duplicate post.

greekman - 21 Feb 2007 18:47 - 106 of 309

Looks like the whole sector had a bad day, probably due to all the talk about the NHS paying over the odds for drugs.
Been this way several times before. Always a bounce back.

parthus - 22 Feb 2007 21:56 - 107 of 309

bought back into pti after a 1yr gap. down app. 4%,pretty sure it will rebound. regard protherics as a well run, good quality pharma. happy to be in for the medium term.

transco - 23 Feb 2007 10:19 - 108 of 309

Dissapointing performance since the rights issue - be carefull with this baby.
It does have the capacity to leave you high and dry.

greekman - 23 Feb 2007 12:58 - 109 of 309

Transco,

I paid 65p for my extra shares. The sp is now 71.75p. Considering consolidation how can you show they have performed badly.
Yes they have dipped from the highs of a couple of weeks ago but this is not an indication of a "capacity to leave you high and dry.
If you can expand on your statement please do so.

transco - 23 Feb 2007 18:55 - 110 of 309

Greekman,

No offence just a few obsevations.

Point 1. They have underperformed the market. (I also purchased @ 65P.)
At at a time when other shares of this type have increased significantly.

Point 2. Track record on rights issues is not good I have held these for years and I have been involved in at least 2.

Point 3. I dont like pumping excercises like the one the IC did on these in December. It usually bodes ill.

Point 4. The company reports dont expect approval for anything until 2008 at the earliest.

Point 5. The company that bought a large stake are sitting on a huge profit and are likely to take some of it at some point.

Point 6. Press reports of drugs being overpriced.

Point 7. Any further delays in testing will see the SP drop sharply.

I could go on but its just my view and will continue to hold for the long term.

greekman - 25 Feb 2007 18:37 - 111 of 309

Transco,

No offence taken. I was just answering your comment "Dissapointing performance since the rights issue - be carefull with this baby.
It does have the capacity to leave you high and dry".

Can't see you have justified your comment. We will have to agree to disagree.

Cheers Greek

parthus - 25 Feb 2007 23:45 - 112 of 309

okay guys,thanks for clearing that one up for me!

transco - 26 Feb 2007 09:27 - 113 of 309

Geekman,

No offence taken.

Transco - Parthus - Could be a long wait have patience!!!

transco - 08 Mar 2007 21:18 - 114 of 309

What did I say???????????

parthus - 08 Mar 2007 22:02 - 115 of 309

i think you said have patience

transco - 09 Mar 2007 08:31 - 116 of 309

True,

But dont be worried by jumping ship either. As I said...
This company has the capacity to dissapoint.

Purchases at the offer price dont look too good now do they?

greekman - 12 Mar 2007 07:50 - 117 of 309

Another 10 mill payment from AstraZeneca, due to the Scaling-up the CytoFab manufacturing process.
Now we can clearly see why the last placing was required. It does look like with this scaling up of manufacturing re CytoFab PTI are well on course.

All indications are that the management at PTI are putting it's cash pot to good use.

Now watch the institutions holdings increase, with hopefully new one's jumping on board.

Transco said a few posts ago...."It does have the capacity to leave you high and dry".

Still could...If my shares end up in about 3 to 5 years where I think they will, I may be high and dry on my own desert island, coconout palms, luxury boat, girls in grass skirts. Sorry Trans, could not resist.

OK, perhaps not but I can dream, can't I???

transco - 12 Mar 2007 09:59 - 118 of 309

Nice one geekman but the pop today soon dried up.
The payments are no surprise and are all factored into the price.
I did read there was a contamination problem at their plant - I do hope its been resolved.
As for palm trees I hope I'm there with you but I have a nasty feeling about this one. The big boys are not on board yet I wonder why?

Still keep the faith!!

greekman - 12 Mar 2007 10:08 - 119 of 309

OK more sells than buys at the moment, but as the sp went up 3p on opening, many appear to be taking a profit, so I don't read too much into it.

I agree it was expected, but always nice to see, as things can and do go wrong,
There are always conditions involved re agreements like these trigger releases of cash, so nothing was set in stone.

Now real money in the bank.

It will be the sp at end of week, that will give a clearer indication of how the market views the latest bit of news.

parthus - 12 Mar 2007 22:20 - 120 of 309

shall i buy a lawnmower then?

transco - 13 Mar 2007 14:43 - 121 of 309

Lawnmower?

greekman - 13 Mar 2007 17:42 - 122 of 309

Trans,

The lawn mower post was referring to my comment 0750hrs of the 12th, (girls in grass skirts). Bet you have been researching the full SEO website re a new product.

greekman - 14 Mar 2007 07:37 - 123 of 309

Looks like this is a push to increasing anti snake venom stock.
Can't do PTI any harm.

Fougera Marks Seventh Snakebite Season With CroFab Crotalidae Polyvalent Immune Fab (Ovine)
Urbanization and Climate Change Driving More Snakebites and New Strategies for Stocking Antivenom in 2007
MELVILLE, N.Y., March 13, 2007 (PRIME NEWSWIRE) (PRIMEZONE) -- Fougera Inc. begins the 2007 snakebite season further ensuring adequate availability of CroFab(r) Crotalidae Polyvalent Immune Fab (Ovine), the only widely available antivenom for North American crotalid snakebite envenomations in the United States.

For Full article see link.....http://www.primenewswire.com/newsroom/news.html?d=115405

transco - 14 Mar 2007 17:04 - 124 of 309

The anti venom product is small beer now.

We need FDA approval of the other stuff.......

SP continues to slide......... what did I say.

greekman - 14 Mar 2007 19:21 - 125 of 309

Transco,

Although now a small part of PTI, CroFab it is still a steady revenue earner.

As for SP continues to slide, I am sure you know as well as we do that it is totally down to the DOW, and is totally out of PTI's control.

parthus - 14 Mar 2007 21:45 - 126 of 309

stop bitching you two

greekman - 15 Mar 2007 07:09 - 127 of 309

Parthus,

Can't see where so called bitching comes into this.We both have differing opinions re PTI as regards, will it make you money or not.
Bitching to me is when things get personal, or/and comments with no back up whatsoever.
There are not many who post on this thread so we do take up a fairly large percentage of posts. I wish there were more to discus PTI with.
You are very welcome to put your views.

transco - 15 Mar 2007 08:43 - 128 of 309

Greeknam,

Well said.

I respect your view and I really hope you are proved right.

Parthus whats your view anyway?

Transco

parthus - 16 Mar 2007 00:33 - 129 of 309

Fair point. I feel pti will be a rocky ride,but imho. the potential upside justifies the risk. Compared to my other holdings: CeNeS,IDData and Phytopharm[CEN,IDD,PYM] Protherics is a safer play. In my view the stock is undervalued,but that's for the market to decide. Regards to you both Parthus

greekman - 16 Mar 2007 07:59 - 130 of 309

Hi Parthus,

I think we all agree re the rocky ride.
Companies such as PTI never have a smooth ride, it's the way of the bio/drug type products.

I saw a paper the other day on a companies product trials, (a medical probe) it was 166 full AA pages long.
This was on a fairly simple device. It makes you wonder just how much written evidence is required from first submission to final acceptance of something more complex like a drug. No wonder it takes so long from concept to fruition.

Cheers Greek.

greekman - 19 Mar 2007 17:44 - 131 of 309

Looks like AXA have increased their holdings a bit, 318,221 added. Can't be bad

transco - 19 Mar 2007 19:12 - 132 of 309

Greekman,

I will take any news as positive.

We are badly falling behind the broader market.

Then again even Glaxo got had a hard time today.

I dont see any major movement until the FDA report early next year.
I will sit on my hands till then.

Transco

parthus - 19 Mar 2007 20:12 - 133 of 309

Just read your post of 1yr ago trans. "Just keep your nerve". It's the same story for this year. I Feel patience will be rewarded handsomely. I'm also happy to hold for the medium term. Regards Parthus.

transco - 26 Mar 2007 20:29 - 134 of 309

Parthus,

Nice one chum!!!

I should have remembered!!

Thanks for the thought!!

greekman - 27 Mar 2007 07:37 - 135 of 309

Things progressing in yet another drug. As with most such progress, this will move very slowly, but it shows PTI are always looking forward. Their R@D must be an envy of most similar market cap bio companies.

parthus - 27 Mar 2007 15:11 - 136 of 309

This new trial is in an area I'm not unfamiliar with. Xenova were running a similar trial on non-operable,re-occuring brain tumours of this nature. The cytotoxic agent was administered directly into the tumour site via a catheter. Unfortunately XEN was swallowed up by a parisitic buyout group. The encouraging point is pti's solid pipeline and stronger financials should carry them further.

transco - 27 Mar 2007 19:51 - 137 of 309

I dont think there is a lot to this story chaps. Suspect that the company broker is looking for any good news they can find to prop up a failing share price.
Sorry to be negative but just my opinion!

parthus - 27 Mar 2007 20:56 - 138 of 309

Yeah it's gonna be a long drawn out story!

greekman - 14 May 2007 08:46 - 139 of 309

Blood Pressure Vaccine In Existence
Written by OJ Fagbire
Sunday, 13 May 2007

Protherics, a British drug company based in Cheshire, claims to have developed and tested a vaccine that will help people control their blood pressure levels. According to the firm, the vaccine has been extensively tested and should be released to the general public within the next half decade.

With high blood pressure being one of the fastest growing killers world wide, Protherics could have another long time winner on their books.
Again not one for the short term, but a possible winner in 4 to 5 years.

transco - 14 May 2007 18:19 - 140 of 309

Exactly jam tomorrow - come on PTI lets see something concrete for once.
Who's the broker in charge - tell the story generate interest!!!!!!!!

greekman - 15 May 2007 10:46 - 141 of 309

Hi Transco,

The thing is with bio type companies, the jam is never now, due to the complexity and time scale for trials of such products.
Protherics are going from strength to strength at a nice pace.
It has never been a blue sky tomorrow share but an investment for the future.
This company are not one for putting out pure hype. Their releases contain good content.

Over the next 12 months there are sure to be updates re several of their products.

If you are looking at a bottom drawer share, this is the one.

A good day yesterday, at at the moment the sp is nicely higher, all on fairly low volume with buys not that much more than sells, which leads me to think a largish order is being filled.

A release soon perhaps of an institutional buy?

All IMHO of course.

hangon - 15 May 2007 15:34 - 142 of 309

Agree - this is old news recirculated...maybe not by the broker...perhaps the writer needed some spending money for the Bank Hol at the end of May (wash my mouth!)
This co has a Pipeline and Cash is coming in, so the current sp is "probably" about right....the "BP-drug" is starting trials (PhII) later this year'07 and we shall have to wait a while for the results....probably 2009

Another angle is that the Government is considering changing the Rules re NHS private medicine - at present if you want a non-approved treatment you have to go private (ie pay for everything)...there is a suggestion that folk would be prepared to pay for "the drug" if they had the treatment in their local NHS hospital....it might be a way to satisfy popular expectations of ever-more expensive treatments. That being so, this story might just turn the Minister's mind as the expected demand is likely to be great - if it does not have the usual (unfortunate) side-effect that Gentlemen would not prefer.
Therefore I suspect "this story" is all to do with the NHS ...and NOT Protherics, or their MM, trying to lift the sp.

transco - 17 May 2007 17:50 - 143 of 309

Here we go again down!
Lower than a snakes belly.
This must be the most frustrating share on the market.

parthus - 17 May 2007 22:45 - 144 of 309

no,CeNeS [cen] is !

greekman - 22 May 2007 08:05 - 145 of 309

Looking at the share price over the last couple of weeks, it is obvious that the news released today had obviously leaked.
The thing is how much has this been priced into the sp.
Not good. But with bio/drug companies knocks such as these are to be expected.
I see a 10% drop before the sp picks up again.

queen1 - 22 May 2007 08:35 - 146 of 309

Protherics said it has agreed to provide additional manufacturing and stability data requirements to support a Biologicals License Application for its Voraxaze in the US, following its recent successful talks with the FDA. The FDA has also agreed to Protherics resubmitting its application as a rolling submission, starting in early 2008.

Protherics will continue to supply Voraxaze on a named patient basis in Europe for intervention use in patients at risk of severe or life-threatening methotrexate (anti-cancer agent) toxicity, the biopharmaceutical company said.

Separately, the company said it presented 'encouraging' OncoGel phase 2a oesophageal cancer data at a US conference and that it is planning to undertake a phase 2b study of the product in combination with chemoradiotherapy in patients in the second half of 2007.

greekman - 04 Jun 2007 19:28 - 147 of 309

Always good to see an institution increase their holdings a few days prior to results.
They could also be taking advantage of the sp reduction over the last couple of weeks. Still if they thought the sp would drop after tomorrow, they would had held off buying till then. Let's hope they got it right.

greekman - 05 Jun 2007 08:00 - 148 of 309

Results.

Revenues up 31.1 mill from 17.7 mill.
Profits (gross) 19.8 mill from 6.4 mill

Research/development, big increase.
Year loss less than market expectations at 3.6 mill down from 9.6 mill

Cash up to 40 mill from 9.6 mill.

Progress looking good in all areas, apart from the recent hiccup we all know about.

All in all a good year for Protherics, with future prospects looking excellent.

greekman - 05 Jun 2007 09:06 - 149 of 309

Although early I would have expected more trades and a rise in the SP by now.
No doubt many are looking at the cash increase as being mainly from the fund raising, instead of the bottom line.
Protherics are cash strong with the present cash burn not putting the company at risk.
It looks as if many were expecting the results to be better re more jam today (now) but drug, bio type companies don't work like this.
Still expect the institutions to increase their holdings.

transco - 05 Jun 2007 11:52 - 150 of 309

I dont see any reason for SP improvement this year.
This explains the move out of PTI recently.

Put your cash elswhere till early next year!

transco - 12 Jun 2007 13:56 - 151 of 309

well it goes from bad to worse!!!

queen1 - 12 Jun 2007 19:09 - 152 of 309

Agreed - appalling day!

greekman - 12 Jun 2007 19:18 - 153 of 309

Still strongly believe in this share, but obviously can only concur.

parthus - 12 Jun 2007 22:11 - 154 of 309

Ouch!

transco - 13 Jun 2007 10:01 - 155 of 309

Im very tempted to get out now while there is something left.
This is all too familiar!

greekman - 18 Jun 2007 17:15 - 156 of 309

Nice to see a director, buying. 50,000 @ 58.5p cant be bad.
The price when bought was parallel to the sp buy at that time.

transco - 18 Jun 2007 17:37 - 157 of 309

25k is nothing to those guys.
its a sham to bolster some confidence after recent falls.

greekman - 19 Jun 2007 08:59 - 158 of 309

Transco,

25k is a fair amount of money, (OK obviously to some people it is just a bit of pocket money) but no one is willing to throw this amount at a lost cause.

Gary Watts is a businessman of some considerable experience. I don't think he would invest this amount if he did not believe he was going to get a good return on the investment.

Garry Watts is currently the Chief Executive Officer of SSL International PLC having previously held the position of Finance Director and Managing Director for Europe. He is also a Non-executive Director of the Medicines and Healthcare Products Regulatory Agency (MHRA), where he chairs the Audit and Risk Committee. Previously, he held executive directorships at Celltech Group plc and Medeva plc. He is a Chartered Accountant and was previously a partner with KPMG, leading the UK healthcare and life science practice.

greekman - 05 Jul 2007 17:54 - 159 of 309

Nice write up in iii by Edmond Jackson. Dated 29.07.07.

Protherics has potential to double.

It's tricky to discern value in a loss-making business with major potential and its shares currently out of favor. In the case of Protherics (PTI), this is no flaky operation launched on the latest fashion: the company is at the cutting edge of critical care and cancer products, with genuinely valuable relationships with major pharmaceutical groups such as AstraZeneca (AZN).

It goes on to talk about frustration of shareholders festering, and also mentions that sentiment is affected due to pre-tax loss will widen from 3.6 million to 17.5 million in its current financial year to end-March 2008.
It also mentions Protherics huge potential and that although a speculative share, its business plan and good steady cash flow.

All in all a good well balanced report.

Due to copywrite, extracts only.

parthus - 05 Jul 2007 18:37 - 160 of 309

thanks for that greek

greekman - 12 Jul 2007 07:17 - 161 of 309

Nice update re Prolarix(TM) phase 1 liver cancer study.

Phase 2 liver cancer study to start in early 2008 by Protherics, with Cancer Research UK reporting on phase 1 also early 2008.

As we know these trials take time and can't be rushed. The important thing is that activation was indicated in ALL patients in the phase 1 trial group.

Progressing nicely.

greekman - 26 Jul 2007 07:32 - 162 of 309

Interim management statement reads very positive.
The future looks good.

greekman - 26 Jul 2007 17:49 - 163 of 309

Looks like AXA have increased their holdings a tad (31,702 ). Every little helps

greekman - 28 Jul 2007 11:30 - 164 of 309

Just goes to show how the market in general can drag companies down.

On Thursday Protherics was among the biggest percentage gainers in Thursday's trading among companies with market capitalizations under $500 million. (no doubt due to the AGM and statement). Even allowing for the UK/USA drop.

Then with nothing directly involving Protherics, this occurs.

On Friday Protherics was among the biggest percentage losers in Thursday's trading among companies with market capitalizations under $500 million.

transco - 24 Aug 2007 04:56 - 165 of 309

hi geek,

The slide goes on and on.....
There seems to be no good news at all - the buy by that director looks sick right now!
Time to get rid?

greekman - 24 Aug 2007 07:07 - 166 of 309

Hi Transco,

Not ditching mine as the company is still very sound and cash steady.
As said many times this is not a company for get rich tomorrow, unless of course the Holy Grail of a drug is found, which can always occur with such a company.
To my mind Protherics is a share you obviously keep your eye on, but don't need to review that often.
As confident as ever.

Although I am never one to point out errors re spelling grammar etc, (I'm dyslexic so without a spell checker I would struggle re posting big time), as it's the content of a post that matters to me, your Hi Geek bought a smile to my face. Slip of the finger no doubt!
If only, I am to IT what Pavarotti is to ballet dancing. Anything with more than an on/off switch causes me big problems. As said, not having a dig, just thought it humorous.

Greek. (Wishing I was a computor Geek).

transco - 12 Sep 2007 00:48 - 167 of 309

Hi Greek,

I take your point.
I am a geek in every sense of the word as I work in IT.
Sorry..... for giving you a bad name..

The thing I am worried about is the lack of news good or bad ...ASM for example have a constant stream of news --- its never ending. PTI on the other hand say nothing....

greekman - 26 Sep 2007 07:30 - 168 of 309

Two licensing agreements announced within 2 days. Great news. Looks like the next 24 months, with what PTI have in differing stages of production, trials, could be very productive indeed.

transco - 26 Sep 2007 10:09 - 169 of 309

The share price reflects the future and I see more disapointments.
If these developments were encouraging they would be showing up by now.
Sorry but optimism is unfounded.

IMHO......

greekman - 26 Sep 2007 10:27 - 170 of 309

Why is optimism unfounded. Protherics are going forward at a decent pace. If you look at development's they are proceeding as expected, with the odd minor blip. As with all bio/drug companies products they don't just jump from the research stage, through the trial stage straight to full production.
The sp is tending to reflect that many look on Protherics shares as a short term share which is never has been or will be.
But as your comment mine is also IMHO. Time will tell as they say.

transco - 26 Sep 2007 14:06 - 171 of 309

Sorry but a 50% slump in the sp over the last 9 months tell the story.
You cant buck the market check out ASM over the same period and despite setbacks.
If PTI come back to start of year levels I will eat my hat!!!
IMHO...

Toya - 19 Oct 2007 09:26 - 172 of 309

Hi Transco and Greekman,

I've been keeping an eye on PTI and reckon something's afoot. Sp up 7.07 this morning, to 49.0-49.5

In the RNS of 26Sept there is this quote from the CEO: "We also have considerable interest from other external parties to use our adjuvant in their vaccines across a range of other potential indications."

Perhaps some new licence deal is on the way?? - I bought some shares this morning, in the belief that some good news is imminent.

transco - 19 Oct 2007 09:50 - 173 of 309

Hi Toya,

I agree - I noticed the same move.

We have looked to have bottomed out for sure - the only way is up!!!!!!!!!!!1

transco - 19 Oct 2007 11:24 - 174 of 309

Another false dawn I'm afraid.
Does this from time to time before resuming its slow decline!!!!!!!!!!11

Toya - 19 Oct 2007 11:27 - 175 of 309

Blast... But I'm sure they'll get some other contracts - must do! Don't want to find myself trapped...

transco - 19 Oct 2007 12:04 - 176 of 309

Sorry Toya but there has been a slow decline for months and its set to continue until more positive news of the drug pipeline.
I would touch this with a bargepole for now!!

greekman - 19 Oct 2007 12:15 - 177 of 309

Toya,

Until there is positive news, I can't see much movement upward, but saying that, I do think such news is not far off, due to the same thinking as yourself, re the RNS from the 26th Sept.
SP up with far more sells than buys. Not on it's own much of a lead, but with 6 mm's on the buy at top shown price and none showing at top sell, now that looks like somethings in the wind.
If we start to see mm's fighting to buy (the last one to move up to the mark was at 1155 hrs) then we should know somethings in the wind.
Of course it could all be smoke and mirrors.

queen1 - 19 Oct 2007 14:04 - 178 of 309

Positive note from a charting perspective in this week's Shares Mag.

transco - 19 Oct 2007 14:47 - 179 of 309

Yes from a chart perspective it looks to have bottomed but I dont hold with charts.
Market makers must have made a few bob on this one over the last few months.
I see no upside without news.

greekman - 19 Oct 2007 15:01 - 180 of 309

Although not a chartist, I do feel they have their place, but more with FTSE 100 type companies that never move in very large percentages, (allowing for the one offs such as Northern Rock).
Charts don't have the same values for smaller sky blue or bust type companies, such as Protherics.
A chart could show such a company heading for a drop and because good news is released the sp could double or more within 24 hours, and of course visa versa.
With large blue chip companies, moves of this magnitude just don't (without the rare as stated exceptions) happen.

transco - 19 Oct 2007 15:39 - 181 of 309

Well said geekman - it just goes to show what impact a small article on PTI's chart can do.

I dread to think what would happen of anything bearish came out.

Back to 20p maybe?

greekman - 19 Oct 2007 16:36 - 182 of 309

Or bullish, 80p maybe. But it does as you say show what any news could do to such as Protherics.

parthus - 19 Oct 2007 23:18 - 183 of 309

i'm confused

transco - 20 Oct 2007 09:38 - 184 of 309

Sell off on Wall St Friday will point the way - another fall

greekman - 22 Oct 2007 08:46 - 185 of 309

With 98% of the FTSE down today, I also expected Protherics to open down, but it did not and at 0845 it's still up. OK only .25p but strange as there appears very little interest in the share.

transco - 22 Oct 2007 10:14 - 186 of 309

Hi Greekman,

No interest whatsoever and no follow up with the spike on Friday.

Need more news.

Toya - 22 Oct 2007 10:14 - 187 of 309

Yes, I was expecting PTI to fall, too, but am pleased to note it's just about holding steady.

I still reckon that they must be negotiating some other deals. If an Akzo Nobel company (Nobilon - as in the RNS of 26Sept) is happy to pay for PTI's technology, then I'm sure there are other significant pharmacos keen to work with them.

I'm going to remain patient an hold.

lex1000 - 22 Oct 2007 19:44 - 188 of 309

Toya,there you go answered your own question on PET thread!

"I'm going to remain patient an hold."

Toya - 25 Oct 2007 20:45 - 189 of 309

Hi Lex1000 - you tracked me down! Yes, and I shall continue to hold. It's ticked up a bit today, to 50-51p, so it's starting to move in the right direction.

greekman - 26 Oct 2007 07:50 - 190 of 309

AXA Holdings.

AXA must feel confident, as 12% is a big slice of a company in monetary terms even one with a market cap the size of Protherics.
I'm always happy for a single holder, be it a PI or investment group to own such a percentage of a companies shares. It's when that percentage reaches toward 30% that I become worried as when they hold such a market share they can become a bit too relative to sp movement should they suddenly decide to reduce. I saw this recently with another share I hold.
But as said quite happy with AXA holding 12%.
Just hope they are calling it right.

Toya - 26 Oct 2007 08:06 - 191 of 309

Morning Greekman - price up nicely to 52.25-53.50. Off to a good start at least.

greekman - 26 Oct 2007 08:16 - 192 of 309

Hi,

Won't get much time to watch the markets today but it is looking progressively better this week, especially with most of their peers taking a knock of late.

Toya - 26 Oct 2007 08:23 - 193 of 309

I won't be able to keep my eye on it all day either, but I'm confident that the price will stay up there even while my back is turned.

greekman - 26 Oct 2007 09:06 - 194 of 309

It may do unless the chartist take note, due to the RSI indicator viewing the SP as approaching overvalued.
Myself... I don't take much notice of chart indicators when it comes to companies such as Protherics, whose fortunes can half/double overnight on one bad/good bit of news.

Toya - 26 Oct 2007 10:00 - 195 of 309

Quite agree.

transco - 04 Nov 2007 14:14 - 196 of 309

This week could be interesting I feel PTI is about to wake a few people up!!!

There must be some news in the pipeline.

greekman - 05 Nov 2007 07:26 - 197 of 309

I think it's anyones guess at the moment re the markets.
What with the cost of oil, sub-prime still bubbling, the dollar situation, Pakistan, Iraq, Turkey/Iran the UK debt, global warming, floods, road congestion, household bills, my bank statement, wifes Xmas wants (ba humbug), ad infinitum.
Think I will hibernate till it's all over.

halifax - 05 Nov 2007 08:16 - 198 of 309

Depends on what you mean by "all over". Suggest you buy a sandwich board and patrol outside the Stock Exchange!

greekman - 05 Nov 2007 08:47 - 199 of 309

Hi Halifax,

Just think what my views would be if I was a pessimist and not an optimist.
But seriously, I think Protherics are in a very good position re their drug portfolio, to greatly increase the sp either on a world stock market pick-up or/and on a positive significant news release re one of their drugs in trial.
In Potherics, I think we are as safe (and safer than many companies) as anywhere at the present.

greekman - 19 Nov 2007 17:39 - 200 of 309

With the build up of Axa and the results out tomorrow, looking forward to 0700 hrs.
With blood all over the markets, PTI had a very good day.

greekman - 20 Nov 2007 08:52 - 201 of 309

The only conclusion I can come to re the SP is the loss that Protherics is making.
Loss is the only negative in the results, although if you look at the loss along with the other figures, it is only the result of the increase in R&D.
Revenue growth is up 31%.
Gross profit up 32%.
Margins about the same at 55.4% (all down to an excellent management team).
Loss before tax up 6.1 mil. (because of the R&D increase).
Net cash up 14.4 mil.
CASH....46.9 mil (so if the same loss bt continued, it could be carried for several years).

Most will look at these figures as indicating a company well on track for profit within the next 12 months with a very prosperous few years ahead.

Because Protherics are a small, market value drug/bio company compared to those bigger boys in the sector who are year by year well into profit making in huge numbers, the share seams to stall whenever the word LOSS is mentioned, or/and the word delay.

Protherics must have the best (for it's size) drug portfolio in the sector, but as we have seen many times, as soon as there is a delay for whatever reason of a drugs progress, the sellers pile in.

I expect delays, disappointments along the way. Thats the way of the beast.
If half of the drug pipeline make it to full production, I will be happy.
And half is well above all drugs from initial conception to full use acceptance.

My belief is that many holders in the past, with probably some still holding just don't understand the ways of such companies products.

I for one will continue to hold for what I believe the future has in store for Protherics.

If only more PI's would look at the fundamentals and compare Protherics with their competitors, of a similar size, and forget at this stage the EPS.

OK if you want Protherics to make you money now then forget it (allowing for the possible upgrade in market sentiment of course). But if you want to be in on the big party, don't wait till the entry fee costs go up.

All IMHO of course.

greekman - 21 Nov 2007 07:50 - 202 of 309

Nice little BUY recommendation from The Independent. Nothing that we don't know from yesterday but the more interest the better.

Protherics, one of the UK's most established biopharmaceutical companies, is gearing up for a big 2008. It is second-nature for life sciences companies to point to jam tomorrow, but with six products entering phase II trials over the next six months, Protherics is able to boast that it has a larger development pipeline than any other UK biotech.

Yesterday's interim results illustrate why Protherics is well-regarded. The company's underlying revenue growth was an impressive 41 per cent at constant currency rates, while its pre-tax loss of 6m was much better than had been expected.

Perhaps more significantly, Protherics reported a cash pile of 47m, giving it the firepower to continue to develop a number of potential blockbuster drugs under its wing.

Be nice to see if there is further institutional interest over next 6 to 12 months.

greekman - 12 Dec 2007 07:58 - 203 of 309

Biotech recruiter Accord Scientific has partnered with international biopharmaceutical company Protherics Inc. to build Protherics' clinical regulatory and senior staff.

Accord was selected to support Protherics after Protherics' acquisition of Utah-based MacroMed Inc., a private drug development and manufacturing company and two in-licensing agreements the company has signed with Glenveigh Pharmaceuticals and Advancell of Barcelona. The three transactions have roughly doubled the size of Protherics' U.S. Operations.

Proves PTI's are treating the USA projects very seriously.

hangon - 17 Dec 2007 22:21 - 204 of 309

How much of the recent weakness is due to Market-fear and folks wanting their Cash back? ( i.e. At any reasonable price).

So do we expect further weakness to sub 50-pence?

40p anyone?

Frankly, I can't see 3.00 anytime, not 2009.= soon . . . . . Not until we see some returns and can price the risk/reward, don't you know?

greekman - 31 Dec 2007 15:43 - 205 of 309

Sp up 4.13% on average volume. Will be interesting to see if there are any institutional buys that come in on Wednesday.

I foresee a good year for Protherics due to their cash position (even more important in the present credit situation) and their drug portfolio.

Happy New Year all.

halifax - 31 Dec 2007 16:15 - 206 of 309

PTI has a market cap close to 200m as an ex shareholder I would like to believe that 2008 will prove to be the year they achieve something tangible but I have my doubts thats why Iam out.

greekman - 14 Jan 2008 16:44 - 207 of 309

Sp up 16.27% @ 8.5p. Last time there was a distinct move up I was looking for a reason, can't really find one unless there is a big buyer out there due to the latest RNS. The problem is with the markets as they have been last 4 months, it's up and down like the proverbial yo yo. But with todays increase surely somethings in the wind.

Tau Ceti - 14 Jan 2008 16:55 - 208 of 309

Probably this rise was this a knock on effect of:

Meldex International confirms potential offer approach received
AFX

LONDON (Thomson Financial) - Meldex International PLC said it has received an approach which may or may not lead to an offer for the company.

A further announcement will be made in due course, the specialty pharma and healthcare company added.

greekman - 14 Jan 2008 17:36 - 209 of 309

Hi Tau Ceti,

Could be but seems a good hike on price just because of the Meldex news.

Cheers Greek.

Toya - 14 Jan 2008 18:52 - 210 of 309

It's a big rise for the last half hour of trading. Can't think it could be just a 'Meldex effect' as some other pharmacos might have been similarly affected. I wonder if there could be some announcement first thing tomorrow? Will certainly keep a close eye on this but, as Greekman says: beware of the yoyo effect with this one!

transco15 - 14 Jan 2008 19:01 - 211 of 309

Im long long suffering shareholder - is this the time for payback?! - I H O P E SO!!!!!!1

Tau Ceti - 14 Jan 2008 19:38 - 212 of 309

Hi Greek,
The Meldex news came out at 3:30 and Protherics started its rise shortly afterwards so that's why I thought they were connected.
TC.

greekman - 15 Jan 2008 07:31 - 213 of 309

I agree the timing is strange re the uptick. Funny thing is the pharma/bio sector was one of the biggest loosing sectors yesterday. Curiouser and curiouser.

greekman - 15 Jan 2008 10:34 - 214 of 309

Some day traders must be making/loosing a mint on this. All down to timing. Can't read this share or the market at all of late.

Toya - 15 Jan 2008 10:40 - 215 of 309

No news appeared so I'm continuing to steer clear of this - too unpredictable

greekman - 15 Jan 2008 11:03 - 216 of 309

Must agree. Anyone buying/selling at the moment is taking a big chance.
I'm treating this as a hold.

greekman - 22 Jan 2008 07:13 - 217 of 309

Always nice to see step progress in any trial.
'First patient being treated in its expanded phase 2 programme of CytoFabTM in severe sepsis'. Hopefully for both patents and investors alike, in 12 months the results will be successful.

greekman - 24 Jan 2008 16:35 - 218 of 309

So another step in progress in a different trial (2 within 3 days) and the sp drops.
Could it be the fact that early 2010 has been mentioned for results of said trial has put people off. Can't understand why some people buy into the likes of Protherics if they don't understand drug time scales. It cant even be profit takers as there are more recorded buys than sells.
Me, I will just sit tight and hopefully have the last laugh.

greekman - 28 Jan 2008 13:49 - 219 of 309

Nice write up re the cancer trial in Pharmalife.http://www.medadnews.com/News/Index.cfm?articleid=508527

greekman - 14 Feb 2008 12:40 - 220 of 309

A very good update, especially with the dollar earnings being hit by the drop in that currency. Looking forward to the next set of results, expecting something really sp positive (news).

transco15 - 15 Feb 2008 07:07 - 221 of 309

Yes but I expect selling today yet again - we never get any momentum going in this market. Hold on though something will inginte eventually!1

greekman - 15 Feb 2008 07:55 - 222 of 309

Hi Transco,

Fully agree. With the market as is latterly, most shares are on the yo yo merry go round. (can you have such a thing?)

parthus - 15 Feb 2008 22:01 - 223 of 309

indeed you can greek, i would go so far as to say it's a yo yo merry go round rollercoaster! and either we're going to throw up or really enjoy the ride. you need a strong stomach for this one . i believe whitestar (15/2/06) has probably got it right. regards parthus

greekman - 19 Feb 2008 17:12 - 224 of 309

Anyone any idea why the big drop today of 4p (7.27%).
Been out all day but can't find any reason.
Aware that the SP has been like a yo yo almost daily over last few months but a 4p drop still appears strange.

queen1 - 22 Apr 2008 19:25 - 225 of 309

The market didn't like this then - down over 10% today...

Protherics said its placebo-controlled Phase 2b Digoxin Immune Fab (DIF) study to treat severe pre-eclampsia has met one of its two primary endpoints. Severe pre-eclampsia is a potentially life-threatening complication of pregnancy for which there is currently no effective treatment other than delivery.

Chief executive Andrew Heath, however, said the results from this small and complex study are not conclusive and added that further analysis of the full data will be required to determine the direction of the programme.

greekman - 23 Apr 2008 07:31 - 226 of 309

I feel the drop is over reaction and expect a recovery over the next few day making up at least half of the loss.

transco15 - 29 May 2008 13:33 - 227 of 309

this is a rubbish share why I hold on I will never know!!

greekman - 17 Jul 2008 13:14 - 228 of 309

Not exactly a stated recommendation to buy, but on reading the article that is the impression given.http://www.pr-inside.com/protherics-plc-corporate-and-strategic-r708336.htm

transco15 - 18 Jul 2008 05:43 - 229 of 309

Geek - Well I have held on for this long...The slump from 40's to low 30's is in line with the market slump but it must be overdone. Then again take your pick on undervalued companies - lots to choose from.
The failure of Phase 2b Digoxin Immune Fab (DIF) didnt go down well.

greekman - 18 Jul 2008 07:40 - 230 of 309

Morning Transco,

Fully agree the test results did not go down well. I think many did look on the results as a total failure, but they were not fully successful which is not quite the same. The tests did result in meeting 1 of the 2 targets.
The group's chief executive Andrew Heath said the results from this small and complex study are not conclusive and added that further analysis of the full data will be required to determine the direction of the programme.
As has been said many times on this thread, many punters want almost instant success, and in the current market conditions any bad news knocks the sp more than warranted.
As you also say "It must be overdone".
Protherics is on my list of the companies for increasing exposure. just waiting till the time is right. I feel that will be when the value of Protherics as a company(especially the potential) takes over from the market view as a whole.

transco15 - 18 Jul 2008 08:59 - 231 of 309

I have averaged down only to lose more - if only on paper.
We need good news flow but nothing expected till end of year early next.
Iwill sit tight.

hangon - 31 Jul 2008 13:00 - 232 of 309

This is a Pharma, with all the risks associated wiith trials - it's very much a wait and see. Some income from rattlesnake divn, so at least shareholders shouldn't see (much) dilution, unlike most other Bio's.
I've held this for a while and this Market dip is rather worse than I expected, so maybe an av dn is looming - but then maybe not. Are you L-T transco15...? I read you're none to happy (earlier posts)......so why did you buy originially?

transco15 - 31 Jul 2008 18:15 - 233 of 309

Well I thought if the big boys were interseted in backing them so should I - I was wrong i think!

greekman - 01 Aug 2008 07:59 - 234 of 309

Personal view. No you were not wrong (obviously depends on the buy in price).
Just lately I have reviewed my reasons for buying into PTI. They were drug portfolio and the relevant stages, low debt, cash in bank and the management team. To me things have on the whole only got better, it's the global trend/confidence in bio/drug companies that has caused the dragging down of the sp.
Punters are looking to 'safe bets' which these days are very hard to find, with so called defensive stocks suffering as much as any.
To me Protherics are looking just as good an investment as ever.
Patience is still needed, but withing 12/18 months I am looking at an sp of at least double today's price, but obviously that is a long time in global terms which at the moment appear to have taken over.
As to the medium/long term of 5 to 10 years I have really high hopes.

hangon - 04 Aug 2008 13:16 - 235 of 309

Greekman, - I tend to agree - - - - Their pre-eclampsia statement was a bit mixed , but it shows the co is still forward-moving and that has to be good.
Furthermore - YES - in these Markets almost any share can be punished - that's why it's essential to hold only those with Lots of Cash (to weather out), OR with income ( esp Pharmas) and exciting stocks that are mid-way.

Big Co's are not always safe, partly because folk can get-out easily and they don't expect a huge change in sentiment whilst they are "out" - whereas small Pharmas may change dramatically....esp Upwards...following a good Trial...

I'm hoping some Normality will happen with the change in US-President and a clearing out of "old ways" etc. Here in UK, we have to wait a little more.... until GB finally gets kicked-out, he was a disaster as Chancellor and now reaps the failures of years of Labour policy of greed and envy.......er, IMHO. I suspect UKplc will be stuck like now until something turns up.

greekman - 06 Aug 2008 14:25 - 236 of 309

3 nice bits of news today, especially the presentation bit.

transco15 - 07 Aug 2008 09:04 - 237 of 309

I would say we have turned the corner,,,i hope....
The charts looking good and im dipping my toe in again..

greekman - 13 Aug 2008 13:43 - 238 of 309

Nicely up today with med volume, sells over 3 to 1 buys with a smaller spread than of late.
Appears the offer is chasing the ask.
On a day with the market suffering, has the previous bits of news (6th) and the Seymour recommendation of being oversold filtering through.

transco15 - 13 Aug 2008 14:49 - 239 of 309

Yes I was right for once - a nice move up - not before time though.

transco15 - 13 Aug 2008 16:18 - 240 of 309

w o w whats going on here. Time to buy more?

greekman - 13 Aug 2008 16:46 - 241 of 309

And the SP finished on a high.

transco15 - 13 Aug 2008 16:57 - 242 of 309

mmm Im not getting carried away. Market conditions are shocking right now. I suspect some buy note is being put together and being released over the weekend..
Still is going in the right direction...... but beware if you are not already in this is a dangerous punt IMHO

greekman - 13 Aug 2008 17:19 - 243 of 309

With the market well down on close and PTI being the second highest riser, there should be a RNS tomorrow even if is to the effect that Protherics have no idea why there has been such a 1 day rise.

transco15 - 13 Aug 2008 17:36 - 244 of 309

Bid stories maybe? Roch had some bid news out i think - maybe its that.
Who knows?
Must retreat in the morning I would guess?

Toya - 13 Aug 2008 20:51 - 245 of 309

Here's your RNS guys - well done to those who had the patience to stick with it (which I did not!):

Released 18:12 13-Aug-08
Number 2944B18

Re share price rise

London, UK; Brentwood, TN, US; 13 August 2008 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, notes today's rise in the Company's share price and confirms it has received approaches from a number of parties interested in acquiring Protherics, which the board is considering. However, there can be no certainty that any formal offer will be made, nor as to the terms on which any offer might be made.

A further announcement will be made in due course.

In accordance with Rule 2.10 of the City Code on Takeovers and Mergers (the "Code"), Protherics confirms that at the close of business on 12 August 2008, it has 342,159,034 ordinary shares of 2 pence each in issue and admitted to trading on the London Stock Exchange under the UK ISIN code GB00070290.

transco15 - 14 Aug 2008 07:39 - 246 of 309

Yes yes yes yes - lets hope they dont sell it south of 90p

greekman - 14 Aug 2008 07:42 - 247 of 309

I posted this on a rival site yesterday.

I just hope it's not someone like Glaxo sniffing around as I would really like Protherics to make it big time on their own. The only suspicion I have re GSK is that as we know they are joined at the hip with PTI on a couple of issues and GSK have made it known they (like many other drug conglomerates) are interested in the buying into drug IP's either by license or straight takeovers as it is often cheaper than their own R@D.
I have no evidence to back up my suspicions, just cant see it being a drug specific news update (unless it's really earth shattering) to make the sp rise 22+%.
Tomorrow will no doubt reveal all.
END

Will only be pleased if any buy out price is 1 plus. Still think if there is a bid it will be lead by Glaxo.
Just on potential I feel that Protherics staying independent is worth far more, but a bird in the hand as they say.

hangon - 14 Aug 2008 16:47 - 248 of 309

Take Care!
This "bid situation" is only making-up lost value, as (bank) financial woes sweep the equity market, and then there's Recession....all of which is bound to affect the willingness of folk to buy Bio-shares, - however valuable/good their pipeline....so this may be a temporary "spike" - take care, don't bet the bank as it were.

Whilst it is welcome, I wonder who it is?

Greekman_ to make it on their own I suspect will be at least another 5-years when commercialisation rests on several products....that's a long time...when I invested (1998?) it seems to be a lot nearer - no one said!

I would have thought, IF it was a Co like Glazo ( mentioned here) then they'd just make a bid at 1(say)- and take the whole thing over. (i.e. their bid would frighten any rivals).... It's very odd that someone would pounce "now" unless it's an oportunistic ploy by Management and they are trying to get the money together, not realising how much reaction the Market would put up.
-Indeed it might be Glaxo that will be their problem, for JV's can be tricky to break and to some extent they help small Bio's from being gobbled-up, whilst giving them a Sales outlet assuming the product works OK.
I hold, long-term.
(Some in an ISA)

greekman - 14 Aug 2008 17:31 - 249 of 309

Just because Glaxo can easily make a 1 per share offer out of their petty cash does not mean they will unless they feel that is its worth. Companies like Glaxo still look for value. If there is an offer it will be good to see the first figure, as this will give a good indication of what might be a final figure. As to the recession, this is one of the reasons why Glaxo have suspended buy backs. They probably feel that with the money market as they are cash can be used in a more productive way
Obviously no predator offers anywhere up to what they deem to be the real worth.
Keeping very rough figures I find that if deals go through the final figure is usually between a 15% to 25% premium to the initial offer figure. If it becomes a competition of suitors then it is often up to 30%.
Now when if due diligence is carried out some of the drugs portfolio looks to have more potential with a money no limit backer well the sp of today might be easily doubled. Of course things can also go wrong, but I can't see Protherics management hiding the wool.
As to 5 years minimum re commercialisation on several products, looking at the time position of PTI's drug portfolio my estimate is nearer 3 years, but yes it could be 5 years if and there is always a big IF with drug issues there are more hiccups than expected.
I fully agree with your "Don't break the bank statement".
Offer or not 'Things can only get Better' as the Labour party used to tell us.

Toya - 15 Aug 2008 07:41 - 250 of 309

From today's Times:

Rumour of the day

Protherics shares surged more than 40 per cent, up 16p to 55p, after the biotech company said it had received several bid approaches after market close on Wednesday. There was speculation yesterday that it could be bought by AstraZeneca, which has a deal dating back to 2005 with Protherics covering CytoFab, its experimental drug for sepsis.

greekman - 15 Aug 2008 08:22 - 251 of 309

Nice little summing up of Protherics.

Zhining Xu, analyst at Seymour Pierce, said: CytoFab alone is probably worth more than the whole market capitalisation of the company at the moment.

For full article see.http://www.ft.com/cms/s/0/59412452-6a28-11dd-83e8-0000779fd18c.html

This is why the value of the company is IMHO over the 1 mark per share, and unless any offer is over this amount I still would proffer Protherics to go it alone.
In 3 years time the 1 valuation could if things go as planned look cheap.

transco15 - 15 Aug 2008 09:49 - 252 of 309

Nice one Greekman - Unfortunately small punter like us wont have a say. I just cannot see more than the rights 65p being offered.
I agree its worth lots lots more but thats how it goes!

greekman - 15 Aug 2008 10:12 - 253 of 309

Possible but once the chase is on between the major pharma players the price will be ramped up by a hopeful bidding war, if only in order to stop rivals getting a foothold in certain sections of Protherics IP's.
Many are cutting back on R@D with Glaxo especially stating they intend to look at other companies drug portfolios. They have also postponed their share buy back scheme in order to put the cash to what they think is a better use, IE buy outs of others R@D developments.
Although I have quoted Glaxo often in this thread since the rumors started re take over this is purely because having Glaxo in my portfolio means I know more about this company than other majors. But I now think like most here that AZ is probably going to be the bid leader.
Whatever the outcome we have not seen such interest in Protherics since, er never.
Once names are thrown into the bidding hat, sparks will really fly, lets just hope we investors don't get burned.

Fully agree that us PI's won't have any say.
Nice to see many differing opinions though.

transco15 - 15 Aug 2008 11:03 - 254 of 309

Yes its possible there could be a bidding war but in this market I think its doubtful.
If it were likely I'm sure the current SP would be higher.
The market makers don't often get it wrong.
I need more than 70p really and I guess other small punters may need more.

On a positive note I don't see much downside from here at all but the upside is limited too......mmmmmmmmm

transco15 - 15 Aug 2008 11:10 - 255 of 309

Inching up this morning.....

greekman - 15 Aug 2008 15:04 - 256 of 309

Good Article valuing Protherics Shares at up to 100.
OK although I wanted Protherics to go it alone, I think 100 per share will do nicely. Where do I vote.
Now where is that contact number for the local Bentley Garage.
A Bentley Continental would look great in my drive.
IF ONLY.
But seriously, I think things will quieten down for a bit with a trickle of info, things wont move overnight.

http://www.bioworld.com/servlet/com.accumedia.web.Dispatcher?next=bioWorldHeadlines_article&forceid=48467

transco15 - 16 Aug 2008 01:53 - 257 of 309

Come on now chaps it must mean 1 per share and 70p per share.
100 would value it near to glaxo - daft...

greekman - 16 Aug 2008 15:45 - 258 of 309

Transco,

Now is it you winding me up. It was tongue in cheek.

transco15 - 17 Aug 2008 12:11 - 259 of 309

Yes I'm winding you up...

I suspect that broker has something to gain by bulling it up.

I cant ever see 1.00 as the take out price.

More like 65p - 70p at the best. IMHO

greekman - 17 Aug 2008 17:15 - 260 of 309

Don't usually put any price on an SP but I will be very surprised if the take out price is less than 1. My bet is 1.10p.

hangon - 18 Aug 2008 09:00 - 261 of 309

Personally I see this as MM having a smirk - almost any news of a bid ( in these days of low sp), means the Co has to issue an RNS - this causes puinters to look at their wallets, meanwhile the City has bought cheaply and will release the stock as the probability of a bid diminishes.

Let's face it, unless the Bid is serious about 1 then PTI Execs will reject it....where else could they find employment if they sold it cheap? - Furthermore they will miss out on the meetings/City-splendour and potential big-bucks "if" one of the Drugs actually works, as they hope.

What on earth would encourage them to sell out at 50p? - it's nearly that now AND they are receiving a very decent living. No, I can't see any BID (other than by the Execs themselves - in which case they should be dismissed without reward) - being successful unless it's 1. More, would be v. nice as others have wished.

Question is, what to do with the small profit I've made from a fortuitous purchase? It was just 2-weeks before the balloon went up.....sure I hold from earlier (higher), but a profit is a profit, they say, and I'm not used to it.

greekman - 18 Aug 2008 10:00 - 262 of 309

Agree re the bid less than 1 comment.
As to the bid itself, it is far passed a rumor stage when a company release an RNS stating, Protherics confirms it has received approaches from a number of parties interested in acquiring Protherics.
No doubt the sp will fluctuate over the next few weeks as if a firm bid was put in today (very doubtful re due diligence etc) the timescale is at least 2 months for finalization, so many who bought in lower than todays price will get impatient and take profits.
But at least we would get to know what any predators approx valuations are.
My betting is that the first firm offer will be at a discount to any final figure of at least 20%.
Like Hangon I am in at differing sp levels, (from 30p to 80p), so I will have to sell at minimum of 63p to make any profit.

greekman - 18 Aug 2008 16:47 - 263 of 309

Nice but very long article re the hunger of big pharmas re Mergers and Acquisitions.
Worth skimming through.

http://www.marketwatch.com/news/story/dealmaking-financing-mergers-acquisitions-pharmaceuticals/story.aspx?guid=%7B04B64222-C339-4D4E-9E8C-E3F650C66A10%7D&dist=hppr

greekman - 18 Aug 2008 16:59 - 264 of 309

Latest.
UK biotech company BTG have just been named as another possible suitor re protherics.
Protherics have also taken on Ashurst corporate partners Andrew Edge and Michael Johns who will be advising on the bids, along with IP partner Dominic Batchelor.

Also an interesting example re high prices being offered.
Oxford BioMedica has turned down takeover bids by the USAs GeneThera, a move which has sent its shares soaring and highlights the increased interest of late in biotechnology firms, especially British ones.

The Oxford-headquartered firm revealed that GeneThera, were willing to pay 0.35 per share more than......four times its closing price on Thursday....., when its value stood at 46.5 million.

4 or even 3 times the closing price of Protherics Wed close of 38p (pre RNS) would do me.

greekman - 18 Aug 2008 17:09 - 265 of 309

Sorry Duplicate Post.

hangon - 19 Aug 2008 13:14 - 266 of 309

Greekman- really!
...( answers to OXB++, on PTI-thread! Sorry)...
There is zero chance GeneThera will bid for OXB -with any hope of success!
GebeThera is a small Bio with hardly any cash and little turnover - Mkt cap is said to be well under $1m- OXB is a Full-List with abt. 50m cash ( That's about 200x the notional value of GeneThera ).
It's a bit like my local Chippy bidding for Macdonalds - it ain't gona happen... Quite why GeneThera sounded-off I don't know; but I'd welcome OXB taking them over...
+The rise in OXB sp is because our MM's think other punters will wake-up to OXB's hidden value.....the Trovax trials are not dead yet....so I topped up at 8p on the bad news a couple of months ago. Due to the falls OXB is no-longer my No1 holding...ahem. OXB trial results are looking dulled, so I don't think we'll see much sp movement - therefore MM's have to stir the pudding.

Protherics appears to be in BID situation, but so far we don't know who! I hope it's not Management - PTI has a decent pipeline, as well as the Rattlesnake product which sells and sells. Previously PTI could command 70p so, today it looks weak...despite the rise...
I can't see BTG being the suitor - they take products and bring them to Market, so if it was a license-deal that might be true....but a Bid?

As for Big Pharma wanting to takeover pipelines - there seems to be no evidence for it, although a few have happened - but no rush, is what I mean -- -some JV, like Sanofi with OXB but they appear to be willing to pay Royalties rather than bid big-cash in one go.
I guess it's cheaper to take smaller bites, which can be financed by Sales.

Any views on Vernalis[VER]-?

greekman - 19 Aug 2008 17:20 - 267 of 309

The link at post 263 shows some hunger for big pharma takeovers and there are many more articles stating that the pharma industry is the one that is at present possibly the most vulnerable sector to such takeovers.
As to BTG like you I think it doubtful, unless there is a big semi outside backer,(the ever present hedge fund or private backer syndicates could be sniffing around but although possible very doubtful). As to AstraZeneca and BTG they have now been named in several newspapers as possible suiters so I would have thought that they would have released a denial if there was no truth in either being interested. But perhaps I am reading it wrong.

transco15 - 19 Aug 2008 19:17 - 268 of 309

Well we shall see greek man. I hope you are correct!!
Nice bounce following low turnover.

greekman - 20 Aug 2008 07:36 - 269 of 309

Morning Transco,

As you say a nice bounce back especially with the markets on both sides of the water having a bad day. I for one expected Protherics to finish down the way things were going so yes, only up a tad but nicely unexpected.

greekman - 21 Aug 2008 15:10 - 270 of 309

Lots of rule 8 releases coming through. Things being sorted as per LSE rules.

greekman - 27 Aug 2008 14:14 - 271 of 309

I was just thinking about topping up with the sp 5% down less than 15 mins ago when it suddenly plunged to 8% down and counting. Something has no doubt leaked as it did 2 weeks ago.
Looking scary to say the least. Although I still think that the current sp with or without a bid is a bargain, if the market does not agree, I will sit on the proverbial fence to see what crawls out. If that makes sense.

greekman - 27 Aug 2008 14:31 - 272 of 309

This could be the reason, although I would have thought this would have had all or most of an effect earlier.

FT Comment - Peel Hunt are repeating their scepticism about PTI expressed earlier in the year and at the time of the original announcement.

Doubts about Protherics' takeover talks sent the drugs developer lower by 5.1 per cent to 55p.

AstraZeneca and Nycomed have both been linked with Protherics, which admitted a fortnight ago to receiving approaches. But Paul Cuddon, analyst at KBC Peel Hunt, said AstraZeneca rarely risked buying companies with unproven drugs, while Nycomed had little strategic use for Protherics' cancer and cardiovascular treatments.

More likely, Mr Cuddon said, would be an all-share offer from a peer such as BTG , down 1.2 per cent to 225p. "If indeed a cash bid has been made in excess of our 29p target price, we would urge investors to accept," he said.

How the hell can they justify taking a bid as low as 29p.

greekman - 27 Aug 2008 16:12 - 273 of 309

Regarding the above. A post on another site has KBC shorting Protherics (anyone have a site that shows if this is correct).

I did wonder if they had an ulterior motive especially when Finncap analyst Keith Redpath has a 100 pence price target on the company, and Seymour who tend to be cautious have a target price of 67p.

Of course any innuendo of bent dealing must be wide of the mark as obviously the market and those who have their fingers in the pie so to speak are whiter than white due to their fear of the LSE and FSA. Aren't they.

Toya - 28 Aug 2008 07:30 - 274 of 309

Interesting comments Greekman - thanks. I'm still in profit with these but did get a bit nervous yesterday!

greekman - 28 Aug 2008 15:56 - 275 of 309

Looks like Barclays have a few shorts to cover, (RNS released 1350 hrs, but not on this site).

transco15 - 29 Aug 2008 11:42 - 276 of 309

This does not look good - looks like a slow death.
Its anyones guess what the outcome will be but I don't like the look of the graph!!
PTI has a reputation for letting punter down!

hangon - 01 Sep 2008 11:14 - 277 of 309

The recent (fantastic!), rise was due to "Bid approach" - and naturally there is a period of excitement - But, slowly folks don't believe a bid will come. However, IF a bid came, it would be below the value the buyer places on the business . . . . so, what value do you think is here?

- - - - - - - - However, the company hasn't changed! - - - - - - - - -

If you liked it before, it's still OK.
FWIW I hold.

greekman - 12 Sep 2008 11:47 - 278 of 309

As there has been no offer made public yet, I can say with some certainty, it will be on Tuesday 23rd Sept. How do I know, because before the market opens on that day I will be on route to Egypt. The last 3 important milestones in my portfolio companies have all occurred when I have been out the loop so to speak.
Also on return from my last 5 holidays my portfolio has been down.
I am beginning to think it's a conspiracy.

Toya - 12 Sep 2008 12:12 - 279 of 309

Thanks for letting us know Greekman! Hope you don't miss out while away this time around

greekman - 12 Sep 2008 13:16 - 280 of 309

Thanks.

transco15 - 12 Sep 2008 17:00 - 281 of 309

A sad sad story ----- its all over for another few years chaps..

greekman - 12 Sep 2008 17:09 - 282 of 309

My take for what it's worth.

In situations such as this (10% price fluctuation) although as I understand it a company does not have to release a statement, unless instructed by the LSE to do so, they usually do, if only to state, 'The company know of no reason why the price has fluctuated by (such and such) an extent'.
But as due diligence is presumably going on they can not say much else unless any potential approach has been withdrawn.
I also feel the sp drops of late are due to those that thought, 'Takeover offer approach, figures within days, all done and dusted within a week'.
I still strongly believe all still in progress.
Just hope I do not have to eat the proverbial Humble Pie, as if it does fall through, for a while thats all I will be able to afford to eat.

Toya - 18 Sep 2008 07:31 - 283 of 309

Greekman: our patience rewarded (and before your holiday!) - go to link below for full statement.

The terms of the Recommended Offer have been agreed on the basis of a price of 206 pence for each existing BTG Share and a price of 60 pence for each Protherics Share which values the Protherics Fully Diluted Share Capital at approximately 218.1 million.

On this agreed basis, the Recommended Offer represents a premium of 45.5 per cent. to the Closing Price of a Protherics Share of 41.25 pence on 17 September 2008 (being the Business Day prior to this announcement) and a premium of 92.0 per cent. to the Closing Price of a Protherics Share of 31.25 pence on 12 August 2008 (being the Business Day prior to the announcement by Protherics regarding potential offers for Protherics).

BTG reaches agreement with PTI

greekman - 18 Sep 2008 08:10 - 284 of 309

Yes as you say before my holiday.
My own personal view is that I would have liked PTI to have gone it alone at least for a few more years. Also it is not yet a done deal, as it is only a recommended deal. Hopefully Acza Zeneca will come back with a better offer although as the deal is recommend and there has been nothing coming out of the Acza camp, it looks like (to my surprise) it is not interested.
At 60p per PTI share I don't think much to it.
Also remember there were others showing interest and as no RNS has been issued stating any have withdrawn interest, methinks a further cash or share deal is still out there.
Keeping very rough figures I find that if deals go through the final figure is usually between a 15% to 25% premium to the initial offer figure. If it becomes a competition of suitors then it is often up to 30%. We can only hope.
Still there won't be much us small holders can do as it will be own to the big boys, although I for one will vote against any deal less than 80p per share.

transco15 - 18 Sep 2008 08:43 - 285 of 309

well 60p but really 50p today - what a waste of effort, just hope thebgc price rises as the market realises its got the sale of the century!!

greekman - 18 Sep 2008 08:53 - 286 of 309

Don't know of many deals that are settled on the first price recommended. Would like to have seen the usual release first, IE 'Protherics have been offered equivalent to 60p per share for the company by BTG. The company will not be recommending the offer as we believe it does not reflect the true value of Protherics'.
Was this the first offer?, and if so why is it being recommended. This is going against the normal trend of Takeovers.

greekman - 18 Sep 2008 17:55 - 287 of 309

Just read the full document re the takeover offer on the Protherics web site.
Interesting read and a good sales pitch re the increased marketing power. Also makes it clear that there are no more offers in the pipeline, others either withdrawn or just not viable.
Would still have thought that the offer price would have been a bit higher, but as said a good read, and the tie up does look promising.

Regards Greek.

greekman - 19 Sep 2008 08:02 - 288 of 309

Just a thouht.
Protherics sell to BTG. AstraZeneca sit on the sidelines watching value of each to drop, then step in to takeover the bigger BTG once all the fire has died down.
OK unlikely but as many including myself have said, can't understand why Astra who are liable to pay licensing payments to PTI and could snap both Protherics and BTG up with their petty cash don't appear interested.
Surely they can't think PTI was not worth 60p plus.
Would like to have seen the list of the potential buyers of PTI and the amounts offered, jut to see if Astra had been sniffing around.
Like I said, Just a thought.

hangon - 19 Sep 2008 11:32 - 289 of 309

Let's look at the alternatives for PTI -
1) The AstraZ link is known and presumably satisfies both parties. If AZ wanted to buy PTI, they've had plenty of insight and opportunity.
However, the price might become rather higher than PTI is valued by their shareholders - so AZ would be fearrful they'll be over a barrel and pay too much. IF then PTI drugs failed, then AZ bosses would collect the wooden-spoon award and maybe lose their job/pension .
This aspect tends to keep large-Co's away from a full t/o. . . . . Nothing to do with shareholder-value, you understand - plain self-interest. . . . .
2) Go it alone - PTI execs will become household-names, riches, options, pensions beyond their dreams . . . . but their chances are slim in BioTech....so it is likely only a dream! Execs put a brave-face on this risk to their future!
3) A tie-up with another partner that's not too big, but "big-enough" - So, the lucky exec(s) retain a job (to steer the PTI-angle)- and being part of a large Co means they can grow into other areas......become rich and still receive most of the benefits of "going it alone!" - but with much less risk of real failure . . . . even if the PTI-angle fails they are likely to have got their feet under the table and have other irons in the fire.
4) Tie-up with a big finance co - the trouble here is the financiers will want to run the tech - take all the benefits and the PTI-Execs will become lab-technicians (in their eyes!)....also there is a tech-risk the big co will steer for quick- profit, rather than a long-term feel-good. In effect, PTI would cease to be...very soon.

With BTG
Firstly (some?) PTI-execs retain their technology-control, maybe even gain access to additional expertise. They can swagger along with a larger badge, yet still have most of the benefits they hoped-for.
In effect it also removes many possibility of failures - either related to a Drug-Trial scuppering Market sentiment (ie forever!), - or being taken-out due to a severe Market reaction to events, say in Wall-Street.

Frankly, I think this is an excellent result for PTI (which I hold, in a minor way) - - - what I'm not so sure about is why BTG has fallen so much, on what looks like a WIN-Win deal. . . . . . Isn't this a share-based deal?

Perhaps I'm missing something but I thought the combined co was to have more cash than BTG had - - so doesn't that mean their cash-piles are combined?

If it's a buy-out, and BTG needs to raise cash, (e.g. by a rights issue), then it's not good in the climate we have today. BTG is my no1 holding, although somewhat battered of late; with daft comments from "Shares" - indeed this combination will make for a stronger pipeline, revenue and "excitment" stock . . . so I should be welcoming this "instant" growth, although there is likely an element of Dilution.
-BUT-
Since we've not seen any "return" any dilution is notional - and as the combined Co is likely to generate more income, the possibility of a return is somewhat nearer! That has to be good, even for LT holders.
(Some of BTG- recent fall is folk bolstering their cash position, due to general market woes and offsetting of losses, elsewhere I suppose.)
+This PTI-move appears to be out-of-the-blue - -- unless any of you heard a rumour- yes I know BTG was suggested mid-August08, but it died away and no RNS, etc . . . . so I suspect this was a "lucky chance" speculation, due to JB being on both Boards, for example - as it made little difference to PTI investors then, did it?

Could another bid arrive? - well yes, but it would have to satisfy the above points that PTI-Execs won't lose-out . . . . and that (this other bidder) won't be paying too much (esp in these woe-days!) . . . . so maybe an existing tie-up is sufficient. By keeping this deal sweet, AZ can add-value later and if the future is bright, then AZ will benefit from earlier arrangements - - - something about "better the d..." =so AZ can remain connected at zero risk (to their Execs).
Another bidder might find the AZ connection soured and this will reduce the value of PTI, either by "time" - or- "cost".... etc.
AZ will have thought of a rival snatching PTI away. So, I suspect BTG is "not seen" in this light.

. . . . . . . . . . . . . One must never forget the "self-interest" rooted in us all.

transco15 - 02 Oct 2008 14:06 - 290 of 309

well it may not be over - things looking up agian

greekman - 17 Oct 2008 16:28 - 291 of 309

If you wish to follow all the takeover rule re PTI, 8.3's don't both on this site as their suppliers don't deem them important enough. See competitors for info.

greekman - 27 Oct 2008 17:49 - 292 of 309

Even in todays market a close of 11.11% down is strange on no news to say the least.
Was OK till just past 1100 hrs then bang.
Of course no part of the market is privy to something we don't know, are they!

hangon - 28 Oct 2008 18:04 - 293 of 309

As I see it, this IS merging with BTG - there is no other game in town....the merger is good for BOTH companies, and will result in a stronger whole.

Falls are across the Market, so this is hardly a surprise...BTG has fallen also, since the ann. - but of the two PTI looks the better Buy, but this should even-out as the day dawns.

greekman - 29 Oct 2008 10:13 - 294 of 309

Hi Hangon,

Whilst agreeing that there were obviously falls across the market, a fall of over 11% did not follow the trend, especially as the drug/bio sector only dropped 3.1%.
Still as they say, 'We are forever mushrooms'.
As to it being a done deal, fully agree as it won't be the PI's that get the say, it will be the big boys who have already provisionally agreed.
In the long term it may well be the tie-up will benefit all shareholders. My reasons for not wanting such a tie-up is that Protherics are in my high risk/blue sky portfolio, so these shares were bought on the hope that they would multiply several times over, obviously excepting the risk of loosing all.
I follow all shares in my high risk strategy with this in mind, so yes I agree the Protherics shares will move into safer more stable territory, but as they will then fall out of my strategy (high risk/reward) the excitement this portfolio gives me will diminish.
A bit like the excitement you have when you bet on a long shot at high odds, yes the chances of winning are low but, well you get the picture.
Still a steady increase/profit obviously won't go amiss, which I agree will happen.
Hope the above makes sense!

Regards Pond

hangon - 04 Nov 2008 11:56 - 295 of 309

I think the merger is the best thing that could happen to BOTH companies - andd maybe cut a few Execs (PTI is somewhat overloaded, IMHO) - and BTG has plenty of cash and more to come at least in the short-term.

As I may have mentioned before PTI has expertise in selling into USA and I understand the combined co will be developing their own team ( but this might be support?) - and this is likely to improve the value of Varisolve - a product that has taken far too long to arrive. Hopefully it will get approval....and the US-connection (with the Rattlesnakes) will enhance their chances - er, IMHO.
Greekman, Thankyou for yr support.... esp.as I've bought a few more PTI recently, on the basis they were "marginly" better value for the same cash. Any mergers create uncertainty and has risks, but normally it is done to enhance one company's turnover ( and darn the cost!) - but here it's a paper-exercise so little cost to funds.... and a strong player for some exciting products.

greekman - 04 Nov 2008 15:44 - 296 of 309

Cheers Hangon,

Time will tell as they say. Moneys, money no matter how it comes, PTI as an independent or as the tie-up with BTG.
Looking down the line, in a couple of years, if this tie-up is looking the better deal (although it will not be that easy to tell) I will gladly admit I was wrong.

Regards Greek.

greekman - 05 Nov 2008 11:13 - 297 of 309

BTG VOTE.

Proposed Acquisition received the overwhelming support of BTG Shareholders, and the resolutions necessary to approve the Proposed Acquisition were passed by the requisite majorities.

No suprise there then.

transco15 - 07 Nov 2008 11:33 - 298 of 309

Nice move up today on news from BTG!!
Looks like the takeover wont be a bad thing after all!!!!!!!!!

greekman - 07 Nov 2008 16:40 - 299 of 309

BTG have released vote giving figures for.

No matter what anyone thinks of this deal statements that include....* Total Against Votes Withheld, really annoy me. Whatever happened to clarity or and democracy.
Presumably it was closer than expected otherwise why not give the figures against.

transco15 - 07 Nov 2008 22:53 - 300 of 309

keep the faith greekman - BGT will deliver im sure of it.

greekman - 10 Nov 2008 08:18 - 301 of 309

So the BTG vote was far closer than I thought it would be, and as to me (obviously a personal opinion) the deal looks better for BTG than PTI could the PTI vote be even closer or even against.

Votes For 98,766,102
Against 88 82,564 0.
Withheld 08 299,464.

hangon - 10 Nov 2008 13:05 - 302 of 309

What surprises me is that there are so many "against" - does that include you, greekman? - can you suggest reasons pse?

by contrast, PTI is running out of money ( it's not serious), since they have some expensive "Trials" and little regular income ( Rattlesnake treatment is relatively small) - so PTI may need to raise money in a few years . . . . so BTG looks like a decent deal and fit...IMHO.

-Indeed, I have heard no suggestions "against" - but hope to hear.

greekman - 10 Nov 2008 13:24 - 303 of 309

Hangon,

See post 294, which fully (hopefully) explains my view. Obviously it's a personal view and I am aware others may be for the deal as it will fit their strategy.
I thought the for vote would have been much higher as I feel that BTG are getting the better end of the deal.
The main point to myself is that I feel Protherics would within a few years make me far more money by staying independent, even allowing for the obvious risk of independence , than if they tie up with BTG, which I agree would be a safer bet.
Still, good to see debate without descending into personal insults as some threads do.

Regards Greek.

greekman - 11 Nov 2008 15:12 - 304 of 309

So its a yes vote, but anyone else spot the deliberate mistake.
Cant they get anything right lately. Surely someone proof reads these releases.

Its in the same format as the BTG vote, although after a struggle I could make those out. The Protherics vote is almost impossible to decipher.
Why cant it just state plainly.
Votes for. Votes against. Votes withheld.

But from another site showing a different RNS format the results show.

No of scheme shareholders voted 785 (99.4%)
Total votes 244,371, 671

No of scheme shareholders voted 'for' 717 (91.3%)
Total of votes 'for' 243,009,601
No of scheme shareholders voted 'against' shows 68 (8.7%)
Total votes 'against 243,009,601 (0.6%)

As the votes for and against in number (but not percentage) are the same obviously this is an error. I have taken the votes for from the total votes cast to give those against at 1,362,070 which would match the (0.6%)

Ain't I the clever one then.

greekman - 20 Nov 2008 08:04 - 305 of 309

Financial Highlights, show everything up that should be up and everything down that should be down, except.....Net cash decrease of 9.6m (2007: increase of 6.9m) in line with expectations, providing a cash position of 28.1m (2007: 46.9m) This in the stage of Protherics as a company was/is expected.
Who needs BTG. OK it will give PTI more pulling power so to speak, but would still have liked them (PTI) to have chanced going it alone. Yes a big gamble but worth it.
In my opinion. BTG have by far the best part of the deal. PTI have sold themselves out far too cheaply.
All IMHO of course.

hangon - 28 Nov 2008 10:04 - 306 of 309

I hold both, although BTG is the Greater position.
However, I thought it was BTG that was getting the worse deal!
PTI has a small income (Crofab) and much to proove with expensive trials - I;m guessing it's touch n' go whether they need more cash - in these Markets forget it. So what could PTI do? If nothing is done now ( when things still look OK ), gradually the sp will slip - and indeed we saw this earlier 2008 - (abt. 25p I recall.)
. . . . . . . How much worse would this get if they did nothing? . . . . .
So, with BTG comming up with Varisolve which is very valuable and probably 10x Crofab, indeed 30x wouldn't surprise me - BTG-holders are expected to welcome PTI shareholders by way of Dilution - well, it seems to me PTI did the better Deal . . . . . but in truth maybe it's fortunate for us both that no money is being lost in the deal - although I'd like to see a culling of pti-execs - far too many for such a small Co. BTG appears to be quite efficient by comparison. ( I attended both AGM's this year).
. . . . . . . . "New BTG" will be a suberb investment and I have been buying PTI recently as this is a cheap-way in, although less-so now it's up. . . . . . . .
+Greekman - are you a L-T holder . . . ?
EDIT(8Dec08),Greekman, that's OK. Good to know you are staying - I sincerely hope this will be Good for investors, but as always we need to keep a watcvh in case Management starts to take their eye off ball...as so often happens -(- I'm somwhat disapointed by PYM...oh deary.)-

greekman - 28 Nov 2008 15:55 - 307 of 309

Hi Hangon,

Yes been in and out for many years now, although my last foray into PTI has been held for about 2 years now, with a couple of small increases over that period.
Still feel we (PTI) drew the short straw but at least all we need to worry about now is BTG making it.

greekman - 04 Dec 2008 13:25 - 308 of 309

Well thats it then, Saying goodbye with not a little regret. Always thought Protherics could have eventually made it big on it's own. Still within a few years we will all know whether this takeover/merger is a good idea or not.
Will hold now in BTG to see how things go.
Any selling out now, just would like to say this as been one of the better threads on MoneyAm, with the vast majority of posts well worth reading.
No doubt we have all learnt something.
Cheers to all.

Greek.

transco15 - 18 Dec 2008 13:07 - 309 of 309

cheers greek!

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