Joined the holders in CBF this morning. Looks like a recovery going on here and I here whispers well speculation of new contract wins. The company seems to be moving away from DNA and focusing on protein and virus production and they seem to be far more focussed.

The company have restructured their sales and marketing team and appear to be more aggresive in their actions.

Fixed and variable costs have also been attacked and the company is working from a lower cost base. The companys order book is higher than it as been for a while and I beleive quarterly profit will be achieved.

Chart also looks strong and shows a break up.

Pointers To Recovery.

From last results 11th Jan.

Sales improvement in the second half of the financial year due to switch
from DNA to proteins and virus.



Restructuring of sales and marketing to address US market.



Restructuring of the Oxford and Keele facilities.



Broadening of customer base - 12 new customers in 2004.



The 4.8m Oxford Facility completed on time and to budget.



Contracted business for financial year 2005 stands at 2.7m.



Financial:


Revenue: H2 2004 up 30% to 2.0m compared with H1 2004 1.5m
FY 2004 down 42% to 3.5m (FY 2003: 6.0m)

Gross margin: H2 2004 49% compared with H1 2004 39%
FY 2004 45% (FY 2003: 57%)

Loss before tax: H2 2004 reduced by 17% to 1.03m compared with H1 2004 1.24m
FY 2004 2.27m (FY 2003: 0.82m profit)

Cash at bank: Sept 2004 3.2m compared with Mar 2004 3.8m (FY 2003: 7.3m)

Loss per share: FY 2004 12.3p (FY 2003: 6.9p earnings)

Director Speak

Commenting on the results, Peter Fothergill, Executive Chairman said:

'Our second half improvement and the current position of our order book are
significant achievements. Management moved rapidly during the year to focus
sales and marketing in the US and from DNA to virus and protein production. This
was no mean feat and we are cautiously optimistic for the future.'

Company Outlook Statement.

Management is actively seeking to broaden the customerbase particularly in the US biotechnology clusters and is examining ways toexpand the service offering including later stage manufacture and there by developing longer-term relationships which can reduce the impact of the high levels of clinical trials failure. These initiatives are already beginning to gain traction with contracted business currently 2.7 million for the financial year 2005 ('2005'), with 52% from North America. If this improvement continues Cobra will recover value for its shareholders.

Fundies.

Presently loss making but looks like the corner has been turned. Awaiting next trading update/results.

Beta.

Fairly High.

Conclusion

Highly Speculative, but the rewards if recovery does take place could be very rewarding.



cheers GF.

Thank you, Alderleyedge, with MMG and CBF and VML, they are winners. Have a good Easter, Alderley.

hyleo have a good one yourself,
here is the mail article

ANALYSTS reckon that major drugs firms will now be knocking on the door of
Cobra Biomanufacturing.It follows the publication of a study showing that pre clinical data supports the potential of the biopharmaceutical makers proprietary Ort-Vac oralbacterial vaccine.Dealers also expect the trading statement on 7th April to confirm that Cobra is now in the best of health.
Shares rose 5.75 to 58p

CBF a company with great potential...

23 March 2005
Pre-clinical Data Supports Potential of Cobra's Proprietary ORT-VAC Oral Bacterial Vaccine
Cobra Biomanufacturing plc (AIM: CBF), the international manufacturer of biopharmaceuticals, today announces the results of a five year research collaboration with the UK Ministry of Defence agency dstl, (Defence Science and Technology Laboratory), Porton Down, UK, on the development of an improved approach to oral vaccination that avoids the risks of using antibiotics or antibiotic-resistance genes.
Comparison of the ORT-VAC system with conventional bacteria vaccine strains show that, post administration, the ORT VAC product is stable and the conventional strains highly unstable. In other experiments reported in the same paper, using a rigorous plague challenge model in rodents, proof-of-principle results published today show that a single oral dose vaccine achieved a high level of immunity against plague.
The results of this research collaboration are published today in the prestigious peer reviewed journal Infection and Immunity (Volume 73, Issue: 4 Page 2005), published by the American Society of Microbiology [http://iai.asm.org/cgi/content/abstract /73/4/2005]
Commenting on the results, Dr David Thatcher, Cobras CEO, said: Cobras scientists are renowned for their innovative approaches. Results from this publication could represent a breakthrough in vaccine strain development as they clearly demonstrate that ORT-VAC technology will allow the production and oral delivery of stable strains carrying a high number of copies of the vaccine gene per cell and therefore ORT-VAC strains are likely to have increased potency compared with conventional strains.
Continuing Dr Thatcher says: The results also show that approaches to the development of high potency oral vaccine strains, using conventional molecular biology, lead to strains which rapidly lose their component antigen genes after administration and therefore are potentially less effective compared with the fully stabilised ORT-VAC vaccines. ORT-VAC approach avoids use of live bacteria which are antibiotic resistant and carry a serious potential of generating antibiotic resistant infection.
The ORT-VAC technology allows easy oral administration and cost effective manufacture of vaccines. It is readily applicable to convert any suitable bacteria strain to an antibioticfree ORT strain for DNA and recombinant protein vaccine delivery in humans. Recombinant protein vaccines are becoming increasingly important as a prophylaxis and as a therapy. ORT-VAC vaccines will have applications in cancer, HIV/Aids and tuberculosis as well as newly emerging diseases, such as avian flu. It will also have utility against diseases such as anthrax posed by the threat of bioterrorism.


2 March 2005
Cobra signs agreement with Hawaii Biotech Inc to manufacture two novel protein vaccines against Dengue fever and West Nile disease for US clinical trials
Cobra Biomanufacturing Plc (London Stock Exchange AIM), has announced that it has signed an agreement with Hawaii Biotech, USA, to manufacture and supply material for clinical trials of vaccines against Dengue fever and West Nile disease. The financial terms and conditions of the agreement were not disclosed.
Hawaii Biotechs vaccine technology is based on the production of proprietary genetically engineered antigens (proteins) that produce immune responses equivalent to or better than traditional live or inactivated virus approaches. The Dengue vaccine product consists of an adjuvant and five viral proteins which have been cloned and expressed in insect cells. The West Nile vaccine product consists of a single recombinant protein and adjuvant. The vaccines potentially have a significantly improved safety profile compared to traditional approaches.
Dengue fever and West Nile disease are growing problems in North America. Dengue fever is expanding globally with an estimated 50 million to 100 million cases of Dengue worldwide annually, with more than 20,000 deaths. Caused by a virus that is carried by mosquitoes it produces severe flu-like symptoms that can lead to a life threatening haemorrhagic fever. Unknown in North America until 1999, the West Nile virus is now permanently established throughout this territory. A significant cause of human illness in the US from 2002, its most serious manifestation is fatal encephalitis (inflammation of the brain). West Nile virus also causes disease in numerous wild and domestic animal species.
Commenting on the agreement, Dr David Thatcher, CEO Cobra said: "This is a significant program for Cobra and we are thrilled to have been selected by Hawaii Biotech. Todays announcement is a valuable endorsement of our ability to manufacture protein vaccine products for US clinical trials and demonstrates our continued ability to penetrate the North American biopharmaceutical market."
David G. Watumull, President and CEO, Hawaii Biotech added: "Hawaii Biotech,Inc is pleased to enter this collaboration with Cobra Biomanufacturing Plc. for the cGMP manufacture of our Dengue and West Nile recombinant subunit vaccine candidates. This is an important step in the preclinical development of these vaccines and critical to the successful launch of our anticipated Phase 1 clinical trials for both Dengue and West Nile vaccines in 2006. We have been impressed by the experience Cobra brings to the table and look forward to a mutually beneficial collaboration."


25 February 2005
Cobra signs long term deal with Neovacs SA to supply Phase I clinical trial material for a novel protein active immunization therapy-TNFa Kinoid
Cobra Biomanufacturing Plc (AIM:CBF.L), the international manufacturer of biopharmaceuticals, announces today that it has signed a long term manufacturing agreement with Neovacs SA to supply clinical trial material for a protein biopharmaceutical, TNFa Kinoid. This novel active immunization therapy against the human cytokine, Tumour Necrosis Factor a (TNFa), will be tested for its efficacy in auto-immune and inflammatory diseases. The terms and value of the agreement were not disclosed.
Overproduction of protein cytokines, such as TNFa, is the cause of many inflammatory diseases. Neovacs Kinoid technology involves inactivating cytokines and conjugating them to a carrier. The resulting cytokine protein complex (Kinoid) serves as an active immunization therapy that induces a natural and potent antibody response by the patients immune system. This enables the harmful cytokines to be neutralised and the disease treated. In addition to TNFa Kinoid, Neovacs is developing other active immunization therapies against numerous human cytokines to treat a range of diseases.
Alain Huriez, CEO of Neovacs, commented: We were impressed with Cobras expertise and track record in protein process development. We feel confident that Cobra will deliver us quality Kinoids on schedule for our Phase I clinical trials.
David Thatcher, CEO of Cobra, said: We are pleased to be selected by Neovacs to produce this novel cytokine protein complex for European clinical trails. This long term agreement recognises Cobras expertise in producing emerging protein therapies and vaccines.


18 February 2005
New trial of HIV/AIDS vaccine incorporates Cobra technology
Cobra Biomanufacturing Plc (AIM: CBF), the international manufacturer of biopharmaceuticals, today announces that its proprietary DNA system has begun clinical evaluation as part of a new HIV/AIDS vaccine clinical trial funded by the European Union.
The Phase I trial is conducted by a consortium (Eurovacc) of organisations including Cobra and will be carried out initially in the UK and Switzerland. The AIDS vaccine involves an initial injection with DNA, designed with the participation of Cobra and using Cobras proprietary ORT DNA backbone and manufacturing technology.
The initial dose is then followed by a booster dose with a genetically engineered pox virus. The DNA-HIV-C vaccine was developed by Professors Hans Wolf and Ralf Wagner at the University of Regensburg based on a representative Chinese subtype C isolate CN54 jointly developed with Professor Yiming Shao from the CDC Beijing, and is designed to combat strains of HIV/AIDS prevalent in Asia and sub-Saharan Africa.

moving along nicely again today!

We seem to be a very small crowd on this thread.Too many people burnt already by this share,maybe.But the news is very exciting.Feel sp would like to rise a lot,but kept back by general pessimism in markets.The chart looks good for a nice ascendancy,first resistance at 75p,if breached on to 90p.Hope this comes to pass!!
Ethel

I dont think this share will have as much in it as 90p for at least 9 to 12 months. Although there have been press reports nothing positive has come out as far as rnx for the company will hover around the 70p for the imminent time being. Im not interested in this share as yet will wait a while unti all the profit takers have finished then re assess over the coming weeks. There are profits to be had elsewhere. Good luck to those holding

I'm with you Bankone, but it's on my radar screen. EK is in this one but GF says he's long. That doesn't instill me with confidence.

LOL

MS

Well here it is - GOOD NEWS - Revise my Post 90p by end of month.

Cobra Bio-Manufacturing PLC
07 April 2005


For Immediate Release 7 April 2005

Cobra Biomanufacturing Plc

AGM Statement/Trading Update


Cobra Biomanufacturing Plc (AIM: CBF), the international manufacturer of
biopharmaceuticals, held its AGM today and made the following statement on
trading for the six months to 31 March 2005.

'Cobra has had a positive six months ('H1 2005') and is currently trading well.
Revenue for H1 2005 is up 50% from the previous six months to 3.0m and the
opening contracted business for the second half of the financial year
('H2 2005') is 2.8m.

'Our change of focus from the smaller DNA market to the manufacture of virus and
the much larger market for proteins has been very effective; protein contracts
now account for 48% and virus contracts for 33% of our contracted business for
financial year 2005. Additionally focusing our sales efforts on the publicly
listed biotechnology companies in North America is also proving to be very
successful and this market now represents 75% of the current year's order book,
including part of a long term contract worth in excess of $3.6m.

'The overall business environment continues to improve, and the company is
competing well as demonstrated by the number of important contracts announced
since the beginning of the calendar year.'

All resolutions at the AGM were passed.


For further information:

Cobra Biomanufacturing Plc Tel: 44 (0) 1782 714 181
David Thatcher, Chief Executive

Buchanan Communications Tel: 44 (0) 20 7466 5000
Tim Anderson/Mark Court/Rebecca Dietrich


About Cobra Biomanufacturing Plc

Cobra Biomanufacturing Plc is a leading international manufacturer of
biopharmaceuticals to the lifescience industry. Founded in 1992, Cobra provides
innovative manufacturing solutions to the biopharmaceutical industry covering
DNA, virus, cellular therapeutics and recombinant protein products.

Cobra was the first company to develop and gain GMP (Good Manufacturing
Practice) standard DNA manufacture in Europe, with specific expertise in DNA
medicines. A range of unique, patented technologies, underpins this revenue
generating business.

Cobra floated on the Alternative Investment Market of the London Stock Exchange
in June 2002 raising 7 million and raised a further 5.2 million in May 2003 in
order to further expand capacity in Oxford UK.

www.cobrabio.com

Thanks for that Bankone, a really positive statement and seems to bode well for the future even with EK in this.
DB66

Evils long on it DB. Strange but have a look at the trades after the AGM?????????????????????????????????????????., ie after the 11.15 am announcement look to be all sells . Have I missed some news whilst on holiday or where investors expecting more from the company ?????????????.

cheers GF.

Cobra Bio-Manufacturing says H1 positive, sales up 50 pct vs previous 6 mths
AFX


LONDON (AFX) - Cobra Bio-Manufacturing PLC said it has had a 'positive' six months and is currently trading well.

Revenue for the first half of 2005 is up 50 pct from the previous six months to 3.0 mln stg and the opening contracted business for the second half of the financial year is 2.8 mln.

'Our change of focus from the smaller DNA market to the manufacture of virus and the much larger market for proteins has been very effective; protein contracts now account for 48 pct and virus contracts for 33 pct of our contracted business for financial year 2005,' the company said.

'Additionally focusing our sales efforts on the publicly listed biotechnology companies in North America is also proving to be very successful and this market now represents 75 pct of the current year's order book, including part of a long term contract worth in excess of 3.6 mln usd.'

The company added: 'The overall business environment continues to improve, and the company is competing well as demonstrated by the number of important contracts announced since the beginning of the calendar year.'

bam

I think cobras held up quite well considering the amount of sells in recent
days.
http://biz.yahoo.com/prnews/050407/to286.html?.v=2

Goldfinger are you sure Evil hasn`t changed his mind? i`m sitting on a small profit and don`t want to lose like i did in MMG. Evil`s getting his arse kicked with SEO so i am wondering if his turning his attention to CBF.
db66

DB he closed down Stanelco last week. Hes certainly long of Cobra and not the other way round.

Nice rise in these aswell today. Good day all round.

cheers GF. PS PM for you.

Well at least this was positive today.

cheers GF.

Holding steady again at the moment,but 150,000 sell has just
gone through and for Cobra that is a big amount!
DB66

RNS Number:8185L
Cobra Bio-Manufacturing PLC
04 May 2005


For Immediate Release 4 May 2005


Cobra Biomanufacturing and Synco BioPartners form alliance to manufacture
plasmid DNA for Phase III trials and commercial supply


Keele, UK, 4 May 2005 - Cobra Biomanufacturing Plc (AIM:CBF.L), the
international manufacturer of biopharmaceuticals and Amsterdam Netherlands,
Synco BioPartners, a leading, contract manufacturing organization, announce they
have formed an alliance to manufacture plasmid DNA for Phase III trials and
commercial supply.

Under the terms of the agreement, Synco has acquired the license to Cobra's
intellectual property rights in the pDNA manufacturing process. This will enable
Synco to manufacture pDNA for both Phase III studies and for commercial supply.
Cobra will continue to offer preclinical, Phase I and Phase II pDNA manufacture.

Synco and Cobra have also agreed to collaborate in the marketing of their pDNA
manufacturing services and to collaborate in providing a first class, integrated
service to potential customers.

Thatcher, Chief Executive, Cobra Biomanufacturing said: "Cobra is proud to
form this important alliance with Synco BioPartners, "Synco is a leading
manufacturer with a licensed facility and an impressive track record in the
production of large-scale recombinant biopharmaceuticals and vaccines for
clinical trials and market supply. Synco has immense manufacturing strengths,
which truly complement Cobra's capabilities in development and IP, making them
an ideal partner."

Pierre Warffemius, CEO of Synco BioPartners B.V. added: " This agreement
leverages our position as a leading CMO in the biopharmaceutical market. We look
forward to a very productive collaboration with Cobra, who are a recognized
leader in the plasmid DNA market and has impressive IP. I believe there are
great synergies between their expertise in pDNA and our specialist, large-scale
manufacturing capabilities and I look forward to offering customers a first
class service".

RNS Number:6446M
Cobra Bio-Manufacturing PLC
24 May 2005

For Immediate Release 24 May 2005

COBRA BIOMANUFACTURING PLC

COBRA SIGNS AGREEMENT WITH INTROGEN THERAPEUTICS FOR MANUFACTURING SERVICES

Keele, UK: Cobra Biomanufacturing plc (AIM: CBF), the international manufacturer
of biopharmaceuticals, today announces an agreement with Introgen Therapeutics,
Inc. (NASDAQ: INGN) for production services.

Cobra will use its expertise in the development of DNA manufacturing strategies
and analytical development to provide GMP manufacturing services for one of
Introgen's clinical stage programs. Financial terms of the agreement were not
disclosed.

David Thatcher, Chief Executive of Cobra, said: "We very much look forward to
helping to provide the manufacturing needs of another US customer. Cobra is
delighted to have the opportunity to apply its experience to one of Introgen's
innovative products now in development. This agreement potentially covers
production of multiple batches of product over the next few years and can add
significant value to Cobra's income stream "

Dr. Peter Clarke, Introgen's Vice President for Production and Technical
Processes, added: "We look forward to working with Cobra as we expand our
programs to include new areas of therapeutic DNA product development. We
believe international relationships can enhance our corporate mission and expand
product development opportunities."


Notes for Editors

About Cobra Biomanufacturing

Cobra Biomanufacturing Plc is a leading international manufacturer of
biopharmaceuticals to the lifescience industry. Founded in 1992, Cobra provides
innovative manufacturing solutions to the biopharmaceutical industry covering
DNA, virus, cellular therapeutics and recombinant protein products. Cobra was
the first company to develop GMP (Good Manufacturing Practice) standard DNA
manufacture in Europe, with specific expertise in DNA medicines. A range of
unique, patented technologies, underpins this revenue generating business.

Cobra floated on the Alternative Investment Market of the London Stock Exchange
in June 2002 raising #7 million and raised a further #5.25 million in May 2003
in order to further expand capacity in Oxford UK.

About Introgen Therapeutics, Inc.

Introgen Therapeutics, Inc. is a leading developer of biopharmaceutical products
designed to induce therapeutic protein expression using non-integrating gene
agents for the treatment of cancer and other diseases. Introgen maintains
integrated research, development, manufacturing, clinical and regulatory
departments and operates a commercial-scale, CGMP manufacturing facility.

This information is provided by RNS
The company news service from the London Stock Exchange

Haven't followed Cobra really so not up with its history. But I am wondering why its been falling and continues to fall on apparently good news? Was more expected?

Cheers, Madison

After the recent dip in SP a welcome rise today.
On the 6th June Fidelity International notified the company stating they owned 701,900 share , 3.60 per cent.Given also that Evil holds a long position in Cobra i am hoping for a rise back to the 70p level that we recently saw.
DB66