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Cyprotex PLC
11 November 2003



Press Release 11 November 2003



Cyprotex reports successful customer validation studies for CloeTM Technology



Cyprotex (LSE: CRX) today announces results of successful trials of its Cloe PK
TM software applied to over 150 potential drugs provided by seven pharmaceutical
companies. The trials showed that Cloe PKTM can estimate how long a drug stays
in the body and is sufficiently accurate to be used in the rapid selection of
promising compounds and the early elimination of those likely to fail.



In parallel, blind trials of the Cloe ScreenTM experimental testing technology
on several hundred compounds provided by six laboratories from major
pharmaceutical companies, all demonstrated a high degree of accuracy.



The CloeTM technology can be used to predict what would happen in humans as well
as in rats, one of the main species used in pharmaceutical research, and the
cumulated data showed that the CloeTM technology allowed the estimation of human
outcomes more accurately than experiments carried out in live rats. These
results demonstrate that customers can confidently use the CloeTM technology to
reduce the number of animals they use in drug discovery research, while
improving the chance that their drug would work in humans.



The detailed results of the trials were described to leading industry and
academic practitioners in the field of computer-based prediction for drug
discovery, who recently visited Cyprotex's laboratories in Macclesfield. The
event was a satellite meeting of the UK QSAR (see below) Discussion Group
meeting, a twice-yearly event which allows industry and academic scientists to
exchange information on progress in the development of computer-based predictive
approaches, which was also hosted by Cyprotex.



Dr David Leahy, Chief Scientific Officer and Founder of Cyprotex plc, said: 'I
am proud of the way that our skilled team of scientists and engineers have
delivered, in less than 18 months, uniquely accurate and cost-effective
technology for the estimation of pharmacokinetics.



'We now have the evidence that demonstrates to potential partners that the Cloe
TM technology can improve productivity in drug discovery. We are able to offer
to our partners similar information to that obtained in a Phase One clinical
trial on every compound they synthesise, at a fraction of the cost, within days
rather than years.'



The acronym QSAR stands for Quantitative Structure-Activity Relationships and
refers to mathematical or statistical relationships between the chemical
structure of a drug and its properties.

- Ends -



Media enquiries:
Bankside
Henry Harrison-Topham / Heather Salmond Tel: +44 (0) 20 7444 4140
heather.salmond@bankside.com www.bankside.com


Notes to editors:

Cyprotex PLC

Cyprotex is a specialist provider of pharmacokinetic information and technology
to evaluate and optimise key properties of potential drugs that determine how
well they will be absorbed, distributed, metabolised and excreted by the body.
This provides pharmaceutical partners with a sound basis for decision-making
regarding compound selection and design that takes into account how the compound
will behave in the body. Cyprotex predicts the likely outcome of administering
either orally or intravenously administered compounds by modelling human and rat
physiology. Predictions require basic compound information that can be derived
in the laboratory using established methods, all of which are routinely
performed by Cyprotex's experimental capability. This unique combination of
technologies is aimed at improving pharmaceutical productivity by improving the
quality of compound libraries and drug candidates progressing through the drug
pipeline. Cyprotex is based in the UK and is listed on the Alternative
Investment Market of the London Stock Exchange (CRX).


This information is provided by RNS
The company news service from the London Stock Exchange

Great news & the orders should start to flood in!

pickit when the 2 contracts come threw the shares will reach 40p imo.the price has been raised to encorage sellers.they want our stock/there may even be a large order that they need to fill.good luck all holders
ps
take a look at this interview with j nicolsonhttp://www.wallstreetreporter.com/profiles/Cyprotex.html

Cheers fredandfreeda

Good news if you have hold

Cyprotex PLC
21 January 2004


Press Release 21 January 2004

ALTANA Pharma selects Cyprotex for drug discovery support

Cyprotex (LSE: CRX) today announces an agreement with ALTANA Pharma AG to
provide drug discovery support using its Cloe ScreenTM technology.

In the agreement, Cyprotex will screen batches of ALTANA compounds across three
assays on a monthly basis to provide essential information on their metabolism
by the liver. These tests use Cyprotex's high throughput in vitro screening
system known as Cloe ScreenTM which profiles compounds for absorption,
distribution, metabolism and excretion (ADME) properties. This agreement comes
after a period of evaluation of Cyprotex's Cloe ScreenTM technology by ALTANA
Pharma which demonstrated it could consistently deliver accurate information on
discovery compounds that would be valuable for supporting effective
decision-making on the selection and improvement strategies of ALTANA's
discovery compounds. The agreement has been set to run for a year and has the
capacity to be extended to additional assays.

http://www.uk-wire.com/cgi-bin/articles/200401210700044512U.html

Todays news is just the begining with 1 of 19 major pharmas contracts in the pipeline for Cyprotex Cloe ScreenTM technology.

Legins
1 of 19? Is this knowledge already in the public domain?

jfletendre,

Yes, if you research back you will find that there is a reference from Cyprotex that they have had trials and +ve results in Cloe for 19 major pharmaceutical companies but have not yet named them specifically.

The phamaceutical market earns $multi-billions a year which the majors are in fierce competition for their slice of it. They also spend $multi-billions a year in R&D and Phase I, II & III clinical trials. Cloe ScreenTM is proven to show that these companies will be able to make huge savings in their R&D budgets and increase revenues in more than one direction.

Because of the following :-

Press Release 13 June 2003

Cyprotex launches Cloe PK(TM),

'virtual human'software to support drug discovery

Cyprotex plc today unveils Cloe PK(TM), a novel and proprietary software system
that accurately predicts, via its 'virtual human' model, the pharmacokinetics
(PK) of potential drug compounds. Using a unique combination of laboratory
tests and sophisticated computer methods, Cloe PK(TM) is attracting worldwide
interest with several large pharmaceutical companies, who are currently
trialling the software with a view to using it as a decision-making tool to
support their drug discovery programmes.

Currently less than 2% of drug discovery projects succeed. Cloe PK(TM) aims to
help increase these success rates by enabling pharmaceutical companies to
discover problematic compounds earlier in the process allowing the company to
focus on the most promising compounds without significant time loss or cost.

AND THIS :-

Press Release 7 July 2003

Cyprotex announces Cloe ScreenTM

World's first large-scale screening facility for profiling all major
pharmacokinetic properties of potential drugs

Cyprotex (LSE: CRX) today announces their successful completion of the
development of a core set of high throughput assay platforms for assessing key
properties that determine whether a compound will reside in the body long enough
to be effective as a drug.

Cloe ScreenTM is a new industrial scale system that can test as many as half a
million potential drugs per year at a significant unit cost advantage to current
methods employed within pharmaceutical and biotechnology companies and by
outsourcing to other contract research organisations. The step change in
efficiency achieved by Cyprotex means that for the first time, pharmaceutical
and biotechnology companies can obtain this essential information, in a cost
effective and timely manner, on every new chemical that they synthesise.

The new test system uses large, high capacity liquid-handling robots supported
by a highly specialised software infrastructure put together by Cyprotex
scientists to quantify important properties such as compound solubility, the
degree of permeation through the gut wall, the speed of metabolism by the liver
and the likelihood of complications that might arise from administration of the
compound along with other drugs at the same time. All of these analyses are
typically done by hand on small numbers of compounds, but through the use of
robotics and supporting software, Cloe ScreenTM makes it possible to deliver
high quality, reproducible results on hundreds of compounds at once in a
fraction of the time.

Commenting on the launch of Cloe ScreenTM, Cyprotex CSO Dr David Leahy said: '
One of the main barriers preventing drug companies from gaining much needed
improvements in productivity is inefficiency in evaluating how potential new
drugs will behave in the body. The launch of our Cloe ScreenTM portfolio will
enable drug discovery teams to obtain critical information on their compounds
much earlier in the discovery process, so they can save time and money by
focussing effort on the compounds that are most likely to succeed as drugs.'

Cloe ScreenTM is part Cyprotex's 'Cloe' family of technologies that have been
created for the pharmaceutical and biotechnology sectors to enable better
ranking, selection and optimisation of new compounds in drug discovery. It
complements Cyprotex's pharmacokinetic predictions software, Cloe PKTM by
providing essential compound information that is used by Cloe PKTM to predict
the outcome of drug administrations. 'Cloe' stands for 'Cyprotex Lead
Optimisation Engine', reflecting the how the Company's family of services
combine to provide operational efficiencies to its clients engaged in drug
discovery.

Cyprotex expects to generate revenue from Cloe ScreenTM through a range of
business models: fee-for-service, applying the capability to partnered projects
in a strategic relationship around lead optimisation; or technology licensing
whereby the entire assay, robotics, software and expertise is brought into a
pharmaceutical partner's own facilities. Cloe ScreenTM is currently in trials
with potential Pharmaceutical and Biotechnology partners.

For the Pharmaceutical

SIGNIFICANT REDUCTION IN COSTS
This technology now means that any one of the Pharmaceutical majors will save $millions P.A. and reduce the risk or prevent adverse effects in new drug compounds or treatments from failing in clinical trials. They will no longer be wasting the investment in 98% of drugs & treatments, that without Cloe, they otherwise fail.

SIGNIFICANT INCREASE IN PROFITS
From the point a new drug is patented, with R&D and Phase I, II, and III clinical trials, it takes on average 7 years before the drug or treatment is on the market and returning a profit. A Patent lasts 25 years before generic drugs or treatments are in competition. Therefore the Pharma Co's revenues are protected for 18yrs. It has been estimated that Cloe PK & Cloe Screen could reduce R&D and Trials upto 3yrs and give 21yrs of protected revenues. This means that the % return on investment into new drug compounds & treatment will rise significantly.

It is an undeniable fact, any Pharmaceutical or Biotechnology company must buy or pay "fee-for-service" for Cyprotex Cloe PK TM & Cloe Screen TM technology or be left behind in the dust. And now ALTANA Pharma AG who is it to be fast on their heels.

Watch closely on more imminent RNS but buy-in and add now IMHO. Here goes my shirt on it!

would this help the shareprice?

Cyprotex PLC
22 January 2004



Press Release 22 January 2004



Cyprotex provides support to drug discovery projects at AstraZeneca

Cyprotex (LSE: CRX) today announces a new agreement with AstraZeneca to provide
essential information on compounds from their drug discovery projects.
http://www.uk-wire.com/cgi-bin/articles/200401220701015065U.html

forgot insert clickable linkhttp://www.uk-wire.com/cgi-bin/articles/200401220701015065U.html

AstraZeneca! Share prices is up 15% before the market opens on this news. This is will be ASTRANOMICAL!

Good announcement.

Great news of the significant contract win for CloeTM with another major pharmaceutical company, this time Roche.

Hi Legins
Thanks for your earlier reply, been away!

picked up at end of today could this be the beginning of another climb tommorrow

Nice climb this morning, before the market even opens, on more contract news for Cloe ScreenTM.

Finals for Cyprotex should be out in about 9 days on 1 Apr 04 or around that date.

Since last interims announced for the 6mths ending 30 Jun 03 there has been the following positive developments and news announcements in the period to year end 31 Dec 03

7th July 03 - Cyprotex announces Cloe ScreenTM. World's first large-scale screening facility for profiling all major pharmacokinetic properties of potential drugs.

12th Aug 03 - Appointment of new Chairman and Chief Executive of Robert Morrisson Atwater immediate effect.

11th Nov 03 - Cyprotex reports successful customer validation studies for CloeTM Technology. Cyprotex (LSE: CRX) today announces results of successful trials of its Cloe PKTM software applied to over 150 potential drugs provided by seven pharmaceutical companies.

23 DEC 03 - Proposed Placing of 30,000,000 New Ordinary Shares at 10p per share
raising 3.0 million (before expenses) by way of a Placing to the proceeds will be used to the proceeds will be used to provide working capital to accelerate its marketing and sales activities in relation to its Cloe ScreenTM and Cloe PKTM products including the acquisition of new equipment and the employment of new personnel to deal with the anticipated growth in turnover.

It is unlikely that expected yr end accounts will be spectacular although there will most certainly have been an improved revenue stream from the previous 13 revenue contracts wins including Roche, Astra Zeneca, and Avidex.

The first quarter of 2004 Cyprotex has started very positively with the following news announcements of agreements with four major pharmaceutical companies.

21 Jan 04 - Cyprotex (LSE: CRX) today announces an agreement with ALTANA Pharma AG to provide drug discovery support using its Cloe ScreenTM technology.

22 Jan 04 - Cyprotex (LSE: CRX) today announces a new agreement with AstraZeneca to provide essential information on compounds from their drug discovery projects. The agreement will make use of Cyprotex's Cloe ScreenTM in vitro technology which cost-effectively profiles new compounds for a variety of properties that affect their ability to be processed by the body.

29 Jan 04 - Three-year agreement with Roche. Cyprotex (LSE: CRX) today announces a three-year agreement with Roche to provide services in support of Roche's drug discovery unit based in Basel, Switzerland.

19 Feb 04 - Solvay selects Cloe ScreenTM for early drug discovery support.
Cyprotex (LSE: CRX) today announces it has entered into a new agreement with the pharmaceutical division of Belgian-based Solvay, the international chemicals and pharmaceuticals group, to provide drug discovery support using its Cloe ScreenTM technology.

With the revenue earning agreements, contract wins and the successful placing to raise 3.0 million to accelerate sales and deal with anticipated growth in turnover. Despite the very positive outlook coming out of Robert Atwater there has been the recent drop of about 30% in the share price and has IMO been partly due to general economic & terrorist market sentiment but in the main is down to MM’s tree shaking and walking down of the price for no other explainable reason other than to gather stock for an expected increase in institutional & retail buying interest leading up to accounts and the expected further contract / agreement news. This news may well get announced in the accounts or not long afterwards as there are a significant number of proven trials with other pharmaceutical & biotech companies which agreements and contracts have yet to be announced.

From a charting perspective, it appears CRX is looking to have now become oversold as it has reached the floor of a bullish 9Mth upward trading channel and is close to previous support levels at 14.75p – 15.5p. MACD, Bollinger & RSI indicators are all looking to turn direction and generate buy signals. The rise in price today may well have been held back due to overall market sentiment from a proliferation of doom & gloom merchants and overshadow the huge growth potential there is in this company.

Support seems to be holding well in readiness to bounce back up. If the long term bullish trend on CRX continues then the next resistance level the share price indicators are predicting to rise to is 27 - 28.5p. DYOR as it could be just about the right time to Buy & Add.

Finals will be out on Monday 19th. I look forward to this date and believe we should see a much better set of results worthy of a re-rating.

Cyprotex share price surged 18.52% on friday ahead of Finals out on Monday. Strong RSI, MACD Buy signals generated. DYOR as open on Monday could see the share price take off vertical especially if there is more contract news announced with results!

Finals show a significant improvement as expected.

Cyprotex PLC
19 April 2004

Press Release 19 April 2004


Cyprotex PLC

('Cyprotex' or 'the Company')

Preliminary Results for year ended 31 December 2003


Cyprotex PLC, a drug discovery technology and information company, today reports
its preliminary results for the year ended 31 December 2003.

Highlights

• Turnover increased 62% to 1.05 million (For previous 14 months
period 0.65 million)
• Pre-tax loss decreased 42% to 2.05 million (For previous 14 month
period 3.51 million)
• 0.8 million raised by issue of 4.5 million New Ordinary Shares
• Post year-end placing raised 2.94 million (net of expenses)
• Agreements signed with AstraZeneca, ALTANA, Roche, and Solvay

Commenting on the results, Robert Morrisson Atwater, Chairman and Chief
Executive Officer of Cyprotex PLC, said:

'At the beginning of the new financial year we effected a successful Placing
which has provided capital that will be used to accelerate our marketing and
sales activities in relation to our Cloe range of products as well as fund the
acquisition of new equipment and employment of new personnel to deal with the
anticipated growth in turnover.

'This year Cyprotex has delivered on a total of 24 revenue generating contracts
with 17 companies and we expect further contracts to be delivered in the near
future. We have demonstrated the effectiveness of our technology, having
received validation from major biotech and pharmaceutical companies that we can
deliver high quality products effectively to customers. We look forward to a
successful year.'



For further information, please contact:
Cyprotex PLC
Robert Atwater, Chairman & Chief Executive Officer Tel: +44 (0) 1625 505 100
rmatwater@cyprotex.com www.cyprotex.com
Media enquiries:
Bankside
Henry Harrison-Topham / Heather Salmond Tel: +44 (0) 20 7444 4140
heather.salmond@bankside.com www.bankside.com


Chairman and Chief Executive's Statement

Financial Summary

Turnover for the year ended 31 December 2003 was 1,052,953. In the 14 months
ended 31 December 2002, turnover totalled 647,770. Gross profit for the year
was 803,101 after deducting cost of sales. For the 14 months period to 31
December 2002, the gross profit was 584,934. Pre-tax losses for the year
amounted to 2,049,401, and after a taxation credit of 189,256 the loss for the
year totalled 1,860,145. The loss per share was 2.05p and no dividend is being
paid.

At the end of December 2003, the Group's cash position was 491,230, but since
then a placing was carried out that raised 2.94 million net of expenses. This
provision of further working capital enables the Group to fund the increased
marketing and sales of its Cloe ScreenTM and Cloe PK(TM) technology and acquire
new equipment and additional personnel to meet the anticipated growth in
turnover.



Product Development

Significant progress was made during the year with the development and
successful launch of our Cloe range of products to support drug discovery. Cloe
ScreenTM is an industrial scale system that produces high quality data on the
absorption, distribution, metabolism and excretion (ADME) properties of
compounds at a fraction of the costs of current methods. Cloe PK(TM) is a novel
system that helps our partners interpret ADME data using a model of a 'virtual'
human or rat to predict the time course of potential drugs in the body. These
technologies can be used effectively in combination to help our partners to
prioritise the best compounds to progress through the discovery and development
process, and to improve the design of new compounds. We are successfully
leveraging Cloe PK(TM) into our sales and we believe that similar integrated
Cloe offerings will generate further new business.

We have already reached the finalisation stage of long-term contracts for our
Cloe-based products with two of the world's largest pharmaceutical companies,
and high-level discussions are continuing with other pharmaceutical and biotech
majors.

Customer Development

Having serviced a total of 24 contracts with 17 global pharmaceutical and
biotech companies in 2003, our portfolio of customers for drug discovery support
services has been further enhanced since the end of the year. Agreements to
provide drug discovery support have been signed with Avidex, ALTANA, Roche,
AstraZeneca, and Solvay that once again demonstrates the value and effectiveness
of our technology.



Board changes

In August 2003, I was appointed Chairman and Chief Executive and since the start
of the current year a number of strategic changes to the Board have been made.
In January 2004, Dr. Martial Lacroix, a Vice President of Montreal-based venture
capital group, Genechem Inc. and Mr Minhaz Manji, the Managing Director of
Monteacute House Limited joined the Board as non-executive Directors.

The Company will benefit greatly from the expertise of these two new directors.
As a result of the continuing development of the Group and these new
appointments, the previous non-executive Directors agreed to relinquish their
Board appointments.

John Nicholson, formerly a Director and Chief Operating Officer of the Company
resigned, along with non-executive directors Dr Colin Picton and Dr Rosemary
Drake. The Board would like to take this opportunity to thank them for their
assistance in the development of the Company and we wish them well for the
future.



Simcyp

The litigation between the Company and the University of Sheffield over disputed
copyright has been dismissed by the Court of Appeal and has since been resolved
amicably. The disputed copyright has not been used nor is it intended to be
used commercially, and the Company long ago ensured that no part of its business
activities or plans was dependent on ownership or licensing of the copyright.
The Company has made sufficient provision in past accounts to cover any costs
that are payable.



Share Option Scheme

The Company is proposing to amend the Rules of the Unapproved Discretionary
Share Option Scheme (the 'Scheme') so that the Directors of the Company will
have more flexibility in determining the price at which options can be
exercised. The Directors believe that it is essential to conserve cash during
the build-up of the Company's business and recognise that its ability to achieve
this will be heavily influenced by retaining and incentivising its highly
skilled scientists and key employees with the availability of options to
subscribe for shares in the Company on attractive terms. Currently the price at
which options can be exercised under the Scheme cannot be less than the market
price on the day before the date of grant which is a significantly restricting
limitation.
Accordingly, it is proposed that the Rules of the Scheme be amended to allow the
Directors to grant options to employees at an exercise price to be determined at
the sole discretion of the Board of Directors. An ordinary resolution to approve
the proposed change will be put to the Annual General Meeting of the Company in
June.


Outlook

2004 has so far been a year of delivering solid progress. We have announced
very beneficial agreements with a number of leading international pharmaceutical
companies including Roche, ALTANA, Solvay and AstraZeneca. We have focused on
creating a quicker and more competitive solution for the drug discovery process
with our accumulated data, which in turn is generating new clients. On behalf
of the Board, I would like to thank everyone who has contributed to Cyprotex's
progress in 2003 - employees, advisors and shareholders. We now have a good
platform for growth and are more able to take advantage of this growing market,
and we look forward to building further on these strong foundations.



Robert Morrisson Atwater
Chairman and Chief Executive Officer
19 April 2004

Chairman & CEO ROBERT MORRISSON ATWATER makes MARKET PURCHASE (THROUGH SIP)of 70,000 ORDINARY SHARES OF 0.1 PENCE EACH in Cyprotex with price per share at 14.50 PENCE (10,000 SHARES)and 14.25 PENCE (60,000 SHARES). Date of transaction 28/04/2004. His total holding following this notification represents 0.06% of issued shares in the company.