Redx Pharma is a drug discovery and development company formed in 2010. It is focused on improving the characteristics of existing drug classes to create best-in-class new drugs in two main areas, cancer and infectious disease. The company's work has been endorsed by partnerships with global pharmaceutical companies and the NHS.


Redx Pharma Plc REDX: AIM First day of trading 27/03/2015



http://redxpharma.com/

/redx-pharma-welcomes-report-on-antimicrobial-resistance

Re: Porcupine inhibitor and cancer immunotherapy
RNS
RNS Number : 1362K
Redx Pharma plc
19 September 2016
 
 
AIM: REDX
 
 REDX PHARMA PLC
("Redx" or "the Company")
 
Redx confirms potential role for Porcupine inhibitor in cancer immunotherapy
 
Redx, the drug development company, is pleased to confirm that its lead cancer treatment, the Porcupine inhibitor (RXC004), has a potential role in cancer immunotherapy.  Redx scientists have demonstrated that the Porcupine inhibitor could have a crucial role in improving the immune system response of some cancer patients when used in combination with an existing immunotherapy, anti-programmed cell death-1 (anti-PD-1).
 
Anti-PD-1 therapy activates the immune system to recognise and attack tumours. While treatment with PD-1 inhibitors, also known as Checkpoint inhibitors, is a significant breakthrough in cancer treatment, not all patients respond.
 
Redx has been testing a combination therapy that uses both the Porcupine inhibitor RXC004 and an anti-PD-1 antibody in a cancer model. The data demonstrates that the combination therapy significantly improves the ratio of favourable T-cells, which attack tumours, to the immunosuppressive T-cells that allow tumours to grow unrecognised, when compared to only using an anti-PD-1 therapy. This suggests that a combination therapy could potentially improve patient response rates.
 
Redx's novel, potent small molecule Porcupine inhibitor has already shown, in disease models, that it has potential as a stand-alone therapy for difficult to treat cancers, such as pancreatic cancer.
 
As previously reported, first-in-human studies for the Porcupine inhibitor, initially as a stand-alone therapy, are expected to commence early in 2017. In addition, Redx is now evaluating opportunities for combination therapies.
Neil Murray, CEO of Redx, commented:
 
"The results so far from our Porcupine inhibitor, RXC004, have been very impressive, with important implications for difficult to treat cancers, such as pancreatic cancer.
 
Over the past few years, significant progress has been made in harnessing the ability of the immune system to attack cancer. We are very pleased that our new findings confirm that our lead cancer treatment, the Porcupine inhibitor RXC004, now also has a potentially crucial role in enhancing existing cancer immunotherapy treatments.
 
Our Porcupine program has progressed from concept to moving towards first-in-human clinical trials in a little under three years, which is a remarkable achievement and evidence of our commercially disciplined approach and outstanding scientific capabilities."

Redx notes breakthrough antibiotic compounds
StockMarketWire.com
Redx has announced the discovery of a series of compounds that have the potential to create the first novel class of broad-spectrum antibiotics in 30 years.

As previously announced, Redx scientists have identified novel bacterial topoisomerase inhibitors that work as antibiotics against drug resistant Gram-negative bacteria.

In vivo testing has now confirmed that Redx has discovered a series of compounds that are highly effective against drug resistant strains of Gram-negative bacteria.

This could have important implications for drug resistant infections such as E. coli and Pseudomonas, which are responsible for critical illnesses such as pneumonia, blood poisoning, and urinary tract and abdominal infections.

In the pre-clinical study, Redx achieved a significant decrease in bacterial infection levels against a multi-drug resistant Gram-negative bacterial strain when compared with tigecycline, a current drug-of-last-resort used in treating antibiotic resistant bacteria.

The Board believes that Redx's compounds could therefore result in the development of a first-in-class treatment in an urgent area of high unmet medical need. Redx will be progressing these compounds with the objective of selecting an optimal lead compound.

Drug-resistant infections are already responsible for more than half a million deaths globally each year and this number is expected to increase.

Of these drug-resistant infections, those caused by Gram-negative bacteria are even more difficult to treat than those caused by Gram-positive bacteria.

This is because Gram-negative bacteria have an additional outer cell membrane that is not easily penetrated by drugs and antibiotics, as well as the ability to expel drugs that do manage to cross the cell membrane. This poses a huge challenge for healthcare providers as Gram-negative bacteria are increasingly becoming resistant to most available antibiotics.

Without the development of new antibiotics that kill drug-resistant bacteria, resistant infections will result in approximately 10 million extra deaths per year and cost the global economy up to US$100 trillion by 2050, according to recent findings from the Review on Antimicrobial Resistance, a UK Government initiative.

27 Sep
Cantor...
105.00
Buy

DYOR - this is only how I see it . . . .
After a loan financial issue in 2017, the suspended shares are out of Administration following a significant drug-right sale for about $40m, which, with a Fundraising, appears to leave them with £12m cash to continue...sp 20p suggests many are wary.
There is much stuff saying good things from the Company and an "independent Report" from Hardman & Co who write these for a living.... however, H won't supply a printed copy...just refer to their Website... which is a fussy alternative IMHO. The Company cannot be contacted - maybe they are having Xmas cheer-up party, or this may be reluctance to provide printed Reports ( just out - see RNS ).

What I do see is that their list of Drug-programme is far short of anything entered Ph1 -which is the most basic...=It doesn't kill healthy patients ( DYOR ). Of course profitable-drugs don't come from thin air, but I'm just not convinced they are discovering much of value to Investors. Maybe they'll be shouting from Rooftops at the next Giddy-go Exhibition, where there is much back-slapping by Execs who are making a gd living already.

Therefore.... the route to lute... may be somewhat long, er IMHO.
Redx (AIM) sp Fell 8% today, currently ~20p