PORTFOLIO REVIEW Last updated: 23/02/06
Billam AG have reviewed the Technical Portfolio of EiRx Therapeutics plc and detail it as follows:
ALIBI genomics discovery platform (2 patents, plus skills and know-how in genomics and cell biology)
Patents on 100+ potential drug targets in apoptosis and tumour cell survival pathways
OSI Pharmaceuticals license agreement milestones of up to $4.9M per target
siRNA technology liposomal delivery vector and panel of 60+ tumour cell lines in 15 phenotypic and functional assays
EnPAD technology skills and know-how in engineering cellular drug screening model
EnPAD -catenin cell line (+ EnPAD PI3K/Akt cell line in development Q1 06)
Pyrazolopyrimidine patent new family of potential drug compounds targeting catenin signalling
2-aminopyridine patent new family of potential drug compounds targeting -catenin signalling
Marie Curie grant programme approx. 400,000 left to draw down
Exclusive commercial license to Aberdeen Colorectal Tissue Bank
Colorectal cancer markers patent on 11 proteins from proteomic study
Cytochrome P450 1B1 intellectual property (3 patents covering diagnostic, therapeutic use)
MGI Pharma license agreement ($100,000 at Phase II, $250,000 at Phase III, $0.5M at NDA, 2% of net sales or 8.5% of sublicense income.
Cytochrome P450 patent 5 more proteins over-expressed in tumours
CYP51 inhibitor project
ArraDx collaboration - 200,000 to come from InterTrade Ireland INNOVA grant
http://www.billamag.net/focus-text-main-quoted.asp?FocusTextID=33