driver
- 30 Mar 2006 17:03
potatohead
- 07 Nov 2006 13:06
- 494 of 1180
LONDON (AFX) - EiRx Therapeutics PLC, the healthcare company specialising in
the control of programmed life and death of cells (apoptosis), said OSI
Pharmaceuticals has opted to license four of its drug targets, thereby
triggering first milestone payment with a potential value of up to 18.8 mln usd.
In a statement, the company said OSI Pharmaceuticals has opted to license
and take forward four of its gene targets into drug discovery for oncology.
A success fee for each target is payable by OSI Pharmaceuticals, as part of
a deal consisting of upfront access and consultancy fees, potential success fees
for each target elected by OSI Pharmaceuticals to license and potential
milestone payments based on successful commercialisation of a novel therapeutic
with respect to each such target.
newsdesk@afxnews.com
ra/ak
potatohead
- 07 Nov 2006 13:59
- 495 of 1180
so what you reckon, news tomorrow from ERX re Oncology
potatohead
- 07 Nov 2006 17:05
- 497 of 1180
what. so you not going to be around when the news is announced then
smiler o
- 07 Nov 2006 17:27
- 498 of 1180
Driver have fun in Scotland, and the sp will still probably be .30 when you get back !!! : )
smiler o
- 07 Nov 2006 18:15
- 499 of 1180
of interest : )
Physiomics PLC
07 November 2006
Physiomics plc ('Physiomics' or the 'Company')
Ordinary Shares of 0.04p
The Company was today informed of the following shareholdings:
EiRx Pharma Limited:
134,834,208 shares representing 36.0 % of the Company's issued share capital
Zyzygy plc:
25,000,000 shares representing 6.7 % of the Company's issued share capital
Billam plc:
41,232,844 shares representing 11.0 % of the Company's issued share capital
Zyzygy plc acquired 25,000,000 shares and Billam plc acquired 33,333,333 shares
in the placing first announced on 1 September 2006.
This information is provided by RNS
seawallwalker
- 07 Nov 2006 23:42
- 500 of 1180
Incestuous investments.
potatohead
- 08 Nov 2006 09:55
- 501 of 1180
and whats wrong with that ;-)
seawallwalker
- 08 Nov 2006 09:57
- 502 of 1180
Dont be touchy, did I say there was anything wrong with it?
potatohead
- 08 Nov 2006 10:16
- 503 of 1180
up and no buys, just sells.. very odd
potatohead
- 09 Nov 2006 14:03
- 504 of 1180
in case any of you are wondering why ZYZ are buying PYC shares, think about it, our director sits on ZYZ board, to take over PYC we will need a controlling share, ZYZ bought ERX shares in 2005 for .0030 and are now selling ERX at .0030, reason.. M&A taking place.
I also think the reason why this is happening is ERX know how much money is coming from OSI and MGI and its far more than we were estimating.
rerating - M&A def on the cards
potatohead
- 09 Nov 2006 15:34
- 505 of 1180
last chance... rumour of news tomorrow
smiler o
- 09 Nov 2006 15:37
- 506 of 1180
???? just looking back to see where you said that before ! : )
StarFrog
- 09 Nov 2006 15:59
- 507 of 1180
Be fair smiler, at least this time the word rumour is included.
LOL
kimoldfield
- 09 Nov 2006 16:19
- 508 of 1180
I'd heard there was only a rumour that there may be a rumour of news tomorrow, or Monday...maybe Tuesday or perhaps some other day! ;-)
kim
potatohead
- 09 Nov 2006 17:19
- 509 of 1180
financials out tomorrow
potatohead
- 10 Nov 2006 15:57
- 510 of 1180
OK NO FINANCIALS.
kimoldfield
- 10 Nov 2006 16:04
- 511 of 1180
Were you the only one who did not know that they are not due yet PH?!!
kim
potatohead
- 10 Nov 2006 16:25
- 512 of 1180
hehehehe they are due in december.. but noone said anything. ;-)
a little trap
potatohead
- 13 Nov 2006 09:31
- 513 of 1180
Ewing's Sarcoma - Apoptotic And Anti-angiogenic Therapies Work Better Together Than Alone
Main Category: Cancer / Oncology News
Article Date: 13 Nov 2006 - 0:00am (PST)
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Prague, Czech Republic: American researchers have found that giving a combination of imantanib (Glivec [1]) and a drug that induces cell death (apoptosis) was better at inhibiting the growth of Ewing's sarcoma in mice than either therapy on its own.
Imantanib works by preventing the creation of new blood vessels to supply the growing tumour (anti-angiogenesis) and the researchers believe that this is the first report of synergy between apoptosis and anti-angiogenic therapy in pre-clinical work.
Professor Andrea Hayes-Jordan reported to the EORTC-NCI-AACR [2] Symposium on Molecular Targets and Cancer Therapeutics in Prague today (Friday 10 November) that treating sarcoma cells with imantanib inhibited a growth factor called PDGFR-beta. This had the effect of increasing the sensitivity of the cells to a drug called tumour necrosis factor-related apoptosis-inducing ligand (TRAIL).
Prof Hayes-Jordan, assistant professor of surgery and pediatrics at the MD Anderson Cancer Center, Houston, USA, said: "When I treated the tumour cells with imantanib, the anti-angiogenic drug, the receptors for TRAIL, the apoptotic drug, increased, thus increasing the efficacy of TRAIL. This was supported by the mouse studies, which showed increased inhibition of pulmonary metastases and primary tumour growth when both were used simultaneously. These findings are important because, if it proves to be effective in humans, it would be well tolerated and have significantly fewer side effects than traditional cytotoxic therapy. Also, at present, we have no effective chemotherapy for pulmonary metastases - the only effective treatment is surgery - so this would give us another option."
Prof Hayes-Jordan hopes to investigate the dual therapy in humans in a clinical trial within 12-18 months.
Abstract no: 474
1. Glivec is known as Gleevac or Gleevec in the USA.
2. EORTC [European Organisation for Research and Treatment of Cancer, NCI [National Cancer Institute], AACR [American Association for Cancer Research].