About ERIX
EiRx Therapeutics is a specialist provider of pre-clinical therapeutics to the pharmaceutical industry. Our unique scientific expertise and knowledge in the field of Apoptosis provide a sound base to discover and develop new medicines that will safely and selectively repair this natural process in disease. The potential benefits from these new medicines are enormous, since as many as 70% of all human disease have some defect in the control of Apoptosis.
Apoptosis - the biological process that determines whether cells in our bodies live or die...
http://www.eirx.com/index.html

Purchased some of these on the strength of the PROGRESS UPDATE looks promising.
http://moneyam.uk-wire.com/cgi-bin/articles/200603200701130254A.html

ERX interview with John Pool
http://www.wallstreetreporter.com/interview.php?id=18589&player=real
Latest News
CANCER COLLABORATION WITH BIOMERIEUX SA
http://moneyam.uk-wire.com/cgi-bin/articles/200607120700230534G.html
Biomerieux Web Site
http://www.biomerieux.com/servlet/srt/bio/portail/home
ABOUT ERX Focus Of The Month
http://www.billamag.net/focus-document-text.asp?FocusTextID=1
ERX pdf filehttp://www.eirx.com/eirx_heading_images/Yokohama2005.pdf
19/09/2006 A 50% reduction in breast tumour volume size seen with Eirx lead molecule in animal studies
http://moneyam.uk-wire.com/cgi-bin/articles/200609190700171175J.html

Past and present collaborative partners include:

* bioMieux SA
* Almac Diagnostics Ltd
* Merck & Co, Ltd
* Biofocus plc
* MGI Pharmaceuticals, Inc
* OSI Pharmaceuticals, Inc
* Sareum plc
* Regen Therapeutics plc
* SR Pharma plc

oh dear... we really dont understand the patent issue do we!!!!

check the erx patent list number 7. we also have numerous collaborations vis biofocus which includes ISIS!!!

sort yourself out lad

Mike111D - 12 Dec'06 - 14:06 - 15064 of 15065


Just a quick note to say that yes Survivin does connect back to ERX and they will comment on this as appropriate in due course.

The immediate priority is to get the results RNS out which is imminent, so expect any update on Survivin to follow but only if appropriate.

As commented on by someone else earlier today, CT has literally just returned from the US, so I think you need to allow them 24-48 hours to get their house in order.

PH - Maybe I'm just thick or something. Could you please enlighten me? As I see it (read the patent) EIRx have a patent concerning the polypeptide SURVIVIN. Eli Lilly will be doing some drug trials on SURVIVIN. Where is the tie-up?

Mike just phoned JP himself, and its confirmed, it is ours.. what is wrong with you today

PH I have looked on the ERX website for a break down of the patents with no joy.
I am assuming as ERX hold the Intellectual Property Rights on Survivin any successful production would invoke Patent?

Sorry, PH, but as I said, maybe I'm just being stupid or something. You are gonna have to spell it out for me.

As far as I am aware, SURVIVIN is the name of a particular polypeptide in the same way that Tungsten is the name of a metal. You can't patent that. EIRx's patent relates to a new way of monitoring changes in SURVIVIN to detect the onset of cell apoptosis.

No connection with Eli Lilly as far as I am aware.

And for your delight and delectation, here is the abstract of said patent:

Abstract of WO03091384
The invention provides a method for detecting apoptosis in a myeloid cell comprising detecting an alteration in any one of: i) a Survivin polypeptide having an amino acid sequence as set out in SEQ ID NO: 1; ii) a polypeptide having at least 80 % homology with i); iii) a nucleic acid encoding a polypeptide having the sequence set out in i) or ii); iv) a nucleic acid which hybridises under stringent conditions to the sequence set out in iii); or v) the complement of iii) or iv). The invention accordingly provides a method of modulating apoptosis in neutrophils by modulating Survivin gene expression and a method of treating inflammatory disease by modulating Survivin gene expression of function.

I already posted it here for you

7 SURVIVIN in my patents list
Inventor: HAYES IAN (IE); COTTER TOM (IE); (+5) Applicant: EIRX THERAPEUTICS LTD (IE); HAYES IAN (IE); (+6)
EC: C07K14/47A1A; C07K14/47A33 IPC: C07K14/47; A61K38/00; C07K14/435 (+2)
Publication info: WO03091384 - 2003-11-06

PH - Posted what? Read my post 728, it gives you the abstract of this patent.

I am not having a dispute with you regarding whether or not EIRx have a patent concerning SURVIVIN. That is materially evident.

What I am asking you, and you are deliberately not answering, is what has it got to do with your news link about Eli Lilly? It is a very simple question? Might I suggest that you are afraid to admit that there is no connection whatsoever.

oh please read the news update.. it states they have moved into phase two

PH - Why avoid my question?

Let me spell it out for you (you seem to have difficulty grapsing simple concepts).

1) Today you have posted that there is great news implying a tie-up with a patent owned by EIRx and work being done by Eli Lilly. In fact you even attempted to start two more threads on the subject.

2) EIRx do have a patent that mentions SURVIVIN.

3) Eli Lilly are about to enter phase 2 trials with work on SURVIVIN.

4) SURVIVIN is the name of a polypeptide and is not patented or owned by any one individual or company.

5) Eli Lilly have no tie-up with EIRx and have announced no programme of work with them.

6) Post 722 - EIRx have no partnership with ISIS.


So the news that Eli Lilly has released (via ISIS) has absolutely no bearing on EIRx.

Or am I missing something here, in which case, and as I have previuosly requested, please enlighten us all.

oh for gods sakes..

are you seriously this blind..

YES YES YES

(AP) - In a Dec. 11 story about licensing deals in the biotechnology sector, The Associated Press erroneously named the employer of analyst Eric Ende. He works for Merrill Lynch, not Bank of America. A corrected version of the story appears below.

NEW YORK (AP) -- Last week's licensing deal between Roche Holding AG and Halozyme Therapeutics Inc. potentially worth as much as $581 million over the next 10 years marked another highlight for the biotechnology sector, as analysts predict licensing costs will get steeper.

Related newsJapanese Stocks Fall; Dollar DownInvestors Seek Signs of Robust SpendingMore Jobs in Nov., Unemployment Up Too
Licensing deals between pharmaceutical and biotechnology companies is the norm for the industry, giving development stage companies the money to continue developing products, while larger companies get a chance to bolster their product pipelines.

But with more large companies facing pipeline holes, biotech companies are seeing more money being thrown their way for innovative products, and the deals could lead to future acquisitions.

"That's going to continue to heat up and pick up," said Jason Napadano, senior biotechnology analyst at Zach's Investment Research. "The reason it's happening is that you have these large pharmaceutical companies with an unprecedented number of products going off patent."

That could amount to billions of dollars in losses for some of the major pharmaceutical companies.

The deal last week between Halozyme and Roche calls for the use of Halozyme's drug delivery technology in products being developed by Roche.

Some of the more standard licensing agreements entail the smaller biotechnology company developing the drug with payments from its larger partner, then splitting, in some form, the profits when it hits the market.

Bank of America analyst Eric Ende said in a November report that smaller biotech companies have been seeing higher deal prices as they seek to gain more control over their products. And big pharma has been willing to pay to fill lagging pipelines. The higher licensing prices are partially leading to more expensive buyout deals.

In October, Merck & Co. said it would buy small biotechnology outfit Sirna Therapeutics Inc. for $1.1 billion. Abbott Laboratories is in the process of buying Kos Pharmaceuticals for $3.7 billion.

"Big pharma could start knocking on the door of biotech with market caps of $5 billion," said Morningstar analyst Karen Andersen.

"If you're a pharmaceutical company and you want these products and need these products, biotech can continue to demand these types of big prices," Zack's Napadano said.

By most estimates, the market for licensing deals and pricier acquisitions will continue into 2007. News last week that Pfizer Inc. ended a late-stage program on its experimental heart drug highlighted the company's pipeline problems, with many analysts predicting it will acquire another company, possibly within the next year.

its your last chance to top up now!!!

I can't find the connection only that survivin is mentioned in the pdf file in the header, having said that if mike says there is one, there may be.

Finds known targets (e.g. aurora, survivin, PKC)

http://www.eirx.com/eirx_heading_images/Yokohama2005.pdf

Also here.

As little as 5 years ago cancer was still thought of largely in terms of a proliferative disease. In contrast, EiRx has built its discovery model around what has now become established dogma; namely that cancer cells critically require a block on the induction of apoptosis. Experiments have shown that proliferative stimuli alone, such as overexpression of the oncogene cMyc, rapidly trigger apoptosis and elimination of the cell. In this context, induction of apoptosis can be seen as a safety mechanism. Blockade of apoptosis can occur through dysregulation of apoptosis effectors such as p53 or from an increase in a survival signals, such as upregulation of discrete genes (e.g. survivin and bcl2) or from the up regulation of an entire survival pathway (e.g. PI3K/AKT).

The charts below illustrates example results from these assays. Survivin and aurora, both of which were identified using ALIBI, represent control genes. Extensive data generated for all kinase, GPCR and other enzyme targets demonstrates direct functional modulation of apoptosis and cancer cell death, from both long term clonagenicity and molecular apoptosis assays. Induction of apoptosis and cell death for many targets compares well with siRNA specific to survivin and aurora controls

http://www.billamag.net/focus-text-main-quoted.asp?FocusTextID=33

there is, its been confirmed by phone by mike if you go over to the dark side

I stand by my post 732.

PH - Your post 735 in response has again NOTHING TO DO WITH EIRx.

Driver - I'm not sure what your handle is on this little tete-a-tete. I'm not denying that EIRx have patents involving the use of Survivin, I'm just questioning PH's implication of a tie-up with Eli Lilly (something that he still refuses to provide evidence for).

I just checked mikes post; he didnt say there was a connection he said, Survivin does connect back to ERX which is a different thing.