About ERIX
EiRx Therapeutics is a specialist provider of pre-clinical therapeutics to the pharmaceutical industry. Our unique scientific expertise and knowledge in the field of Apoptosis provide a sound base to discover and develop new medicines that will safely and selectively repair this natural process in disease. The potential benefits from these new medicines are enormous, since as many as 70% of all human disease have some defect in the control of Apoptosis.
Apoptosis - the biological process that determines whether cells in our bodies live or die...
http://www.eirx.com/index.html

Purchased some of these on the strength of the PROGRESS UPDATE looks promising.
http://moneyam.uk-wire.com/cgi-bin/articles/200603200701130254A.html

ERX interview with John Pool
http://www.wallstreetreporter.com/interview.php?id=18589&player=real
Latest News
CANCER COLLABORATION WITH BIOMERIEUX SA
http://moneyam.uk-wire.com/cgi-bin/articles/200607120700230534G.html
Biomerieux Web Site
http://www.biomerieux.com/servlet/srt/bio/portail/home
ABOUT ERX Focus Of The Month
http://www.billamag.net/focus-document-text.asp?FocusTextID=1
ERX pdf filehttp://www.eirx.com/eirx_heading_images/Yokohama2005.pdf
19/09/2006 A 50% reduction in breast tumour volume size seen with Eirx lead molecule in animal studies
http://moneyam.uk-wire.com/cgi-bin/articles/200609190700171175J.html

Past and present collaborative partners include:

* bioMieux SA
* Almac Diagnostics Ltd
* Merck & Co, Ltd
* Biofocus plc
* MGI Pharmaceuticals, Inc
* OSI Pharmaceuticals, Inc
* Sareum plc
* Regen Therapeutics plc
* SR Pharma plc

Company EiRx Therapeutics PLC
TIDM ERX
Headline Collaborative Agreement
Released 07:00 09-Mar-06
Number 5175Z



For immediate release
9th March 2006






EIRX THERAPEUTICS PLC

("EiRx" or "The Company")



EiRx and Almac Diagnostics Sign Joint 400K Colorectal Cancer Agreement


Cork, Ireland, 9th March 2006 EiRx Therapeutics plc (AIM: ERX), the drug discovery company developing targeted therapies initially for the treatment of colorectal cancer, announces that it has signed a collaborative agreement with applied genomics specialists Almac Diagnostics Ltd of Craigavon, Northern Ireland. The agreement provides terms for the creation and commercialisation of intellectual property arising from a research alliance between the two companies.



The collaboration is being facilitated in part by the InterTradeIreland INNOVA Collaborative R&D program which will contribute up to 400,000 to fund salaries, research expenses, protection of intellectual property, overheads, travel and other allowances over a two year period.



Under this alliance EiRx will use its ALIBITM platform to design and model the transformation events and mechanisms associated with resistance to apoptosis (cell death) that occur in the early development of colorectal cancer. Almac Diagnostics will measure and correlate gene expression changes associated with the transformation using gene microarray technology. The molecular function of candidate genes in colorectal cancer cells will then be validated using EiRxs proprietary siRNA delivery system and in-vitro apoptosis assays. These targets will form the basis for the design of new drugs designed to selectively and specifically induce apoptosis in colorectal cancer cells.



EiRx and Almac Diagnostics view the signing of this agreement as the first phase of a strategic alliance that is expected to expand as the two technology-driven companies work together to develop enhanced treatments for colorectal cancer.



Commenting on the collaboration, EiRx COO Colin Telfer said: We are delighted to sign this collaboration with Almac Diagnostics, whose leading expertise in microarray technology combines with EiRxs skills in functional genomics and translational biology to create a powerful competitive edge. We believe our collaboration will lead to significant advances in understanding of the molecular basis of colorectal cancer and drive our mission to develop new and better medicines.



For further information, please contact:



EiRx Therapeutics plc


John Pool, Chairman
01260 226529

Buchanan Communications


Tim Anderson / Mark Court / Mary-Jane Johnson
020 7466 5000






Notes for Editors:



About EiRx

EiRx Therapeutics (AIM: ERX) is a research-driven healthcare company developing new targeted therapies for the treatment of cancer. The company, which is headquartered in Cork, Ireland, conducts drug discovery from its laboratories in Cork and in Aberdeen, Scotland, and has an initial focus on colorectal tumours, currently the number two cause of cancer-related deaths worldwide.



Since its foundation in 1999 EiRx has developed into a leader in the study of functional pathways critical to cancer cell survival and growth, with a research base encompassing apoptosis biology, translational medicine and the metabolic basis of drug resistance in tumours. Using its state-of-the-art, proprietary ALIBI(TM) platform, EiRx has gained new insights into the mechanisms underlying a cell's decision to survive or die, and has implicated a range of novel genes in pivotal control mechanisms such as the PI3K/AKT and GSK/Wnt survival pathways. In combining functional validation technologies with unique clinical resources such as the ACCRI-BANK tissue collection, EiRx is linking the molecular activity of these targets with clinical consequences in patient populations. By streaming validated targets into an innovative compound screening approach EiRx is creating a product development engine specialising in cancer target discovery, validation and targeted therapy.



The EiRx business strategy is three-fold, and integrates (i) discovery and out-licensing of validated cancer diagnostic and drug targets, (ii) discovery and development of new anticancer drugs through independent or collaborative research, and (iii) application of proprietary knowledge and technologies through collaborative R&D initiatives.



Notable milestones in 2005/6 include:



acquisition of oncology company Auvation Ltd



collaborative research agreement with Merck & Co. Inc. to evaluate EiRx's siRNA delivery technology



award of a Marie Curie Programme grant from the European Commission, to support development of the company's screening, chemistry and efficacy testing capabilities



development of the EnPADTM drug screening technology to enable identification of compounds that specifically target cell survival pathways



filing of patent applications on first series of potential anti-cancer compounds identified using EnPADTM, which target the b-catenin signalling pathway to selectively kill colorectal and breast cancer cells in vitro



filing of patent application describing a second series of potential anti-cancer compounds identified using EnPADTM





ALIBITM platform

To identify effective drug targets it is vital to differentiate between genes that are causal and those that are consequential to the biological process under study. EiRxs ALIBITM drug target discovery platform exploits physiological, disease and process-relevant cellular models to achieve this goal. Practical application of the ALIBITM platform has been validated in a detailed analysis of the apoptotic mechanism, and works as follows. An appropriate cellular disease model is selected and a series of assays designed to focus and steer signalling pathway analysis. The apoptotic mechanism and its counteracting survival pathways are subjected to extensive molecular characterisation (genomic and biochemical) to determine kinetics, functional dependency and the ability of inhibitors and siRNA reagents to modulate the targeted cellular processes. Output data is analysed using a suite of bioinformatics tools, resulting in identification of candidate drug targets whose expression is highly correlated with the apoptosis and survival process across the entire assay panel. The current study will utilize the principals of ALIBITM to model the very early events associated with cellular transformation of colorectal cells, thereby identifying specific molecular components which can be targeted by new colorectal cancer drugs.



For more information visit www.eirx.com





About Almac Diagnostics

Almac Diagnostics Limited (www.almac-diagnostics.com) is a cancer diagnostics company that was founded in 2003 by Professor Patrick Johnston and Professor Paul Harkin from Queens University Belfast in partnership with the McClay Trust and is based in Craigavon, Northern Ireland. Almac Diagnostics Ltd is committed to the development and clinical validation of the next generation of cancer diagnostics products.



Almac Diagnostics Ltd believes that its approach of harnessing high throughput enabling technologies combined with state of the art bioinformatic tools to precisely define gene expression changes is essential to the development of the next generation of microarray based cancer diagnostic products. Almac Diagnostics is working closely with some of the worlds leading genomics companies to achieve these aims.



Almac Diagnostics is part of the Almac group of companies, a privately owned group of affiliated companies comprising four principal divisions, CTS (Clinical Trial Services), CSS (Chemical Synthesis Services), PDMS (Pharmaceutical Developmental and Manufacturing Services and ICTI (Interactive Clinical Technologies Inc). Almacs headquarters are based in Craigavon, Northern Ireland with facilities in mainland UK and the United States (www.almac-sciences.com) as well. Almac Diagnostics has benefited from the extensive networks already established by Almac Sciences in the pharmaceutical industry and aims to spearhead Almacs expansion into the genomic service market.



For more information visit www.almac-diagnostics.com





About colorectal cancer

Colorectal cancer is the third most common cancer in both sexes, accounting for between 10 and 15 percent of all cancer diagnoses. Although highly responsive to treatment when detected at an early stage, the prevalence of late-stage diagnoses means it is second only to lung cancer in the number of cancer deaths it causes. According to the World Health Organisation, almost 950,000 people worldwide were diagnosed with colorectal cancer in 2000 and about half that number died.



END

not long now chaps.. not long at all

lets just keep reminding JP of his interview

AUDIO INTERVIEW
http://www.wallstreetreporter.com/interview.php?id=18589&player=wma

extremly undervalued!!!!! thats what he said

PROVE IT!!!! ;-)

lets just keep reminding JP of his interview

AUDIO INTERVIEW
http://www.wallstreetreporter.com/interview.php?id=18589&player=wma

extremly undervalued!!!!! thats what he said

PROVE IT!!!! ;-)

Market makers have killed all trading this afternoon with the spread.

lets just keep reminding JP of his interview

AUDIO INTERVIEW
http://www.wallstreetreporter.com/interview.php?id=18589&player=wma

extremly undervalued!!!!! thats what he said

PROVE IT!!!! ;-)

Ok PH !!

">

Look into my eyes


BUY ERX, SELL SEO, BUY ERX, SELL SEO, BUY ERX, SELL SEO

this is what I am hoping for on friday

"John K Pool"
13/11/2006 17:14
To

cc

Subject
Re: Shareholder Question





We are looking at producing an analysts note currently We are not
considering going back to the market, if at all, without some very
significant news
John
----- Original Message -----
From:
To: "John K Pool"
Sent: Monday, November 13, 2006 5:10 PM
Subject: Re: Shareholder Question


> John,
>
> Yes I understand this, but my concern is if we dont get some cash soon ERX
> will run out of cash and turn to the market, which I really am hopeing
> this
> will not be the case. I am hopeing the milestone payments will fund us for
> a number of years.
>
> As you know I commented on the marketing, we have changed broker but no
> broker update, I have noted some PI's have asked Seymore pierce why there
> is no broker note, and they say there is none, why not???, this I believe
> is putting many potential investors off.
>
> I look forward to receiving the annual report
>
> Kind regards
>

Hoping for goods news as well on Friday but like you find it a crazy day and not thought out well.Even today is dead.Hope things pick up later.By the way sorry to hear about your bad news hope things get better.

thx

Just bought 100,000 shares & it would only let me buy a max 150,000 online and there was no discount. i reckon the MM are looking for cheap shares ready for Friday, as i could see no reason for dropping the sell price when there were far more shares bought than sold yesterday.

Marcel,well done must be that one and only buy at 0.32p

lets see what the afternoon brings eh!!! MM's running out of time on this one

the dark side bb's are all down.. they have had problems all of last week

Katsy - 19 Dec'06 - 12:17 - 16704 of 16707


Press Release: ErbB2 (Her-2) and p53 : Important Antibodies for ...Hawkings, EF Medical, EiRx Therapeutics Ltd, Elan Computing Schweiz AG ... Human p53 protein has been shown to be phosphorylated at several N-terminal and ...
www.pharmiweb.com/pressreleases/pressrel.asp?ROW_ID=1795 - 63k - Cached - Similar pages

News from 06/11/06

Unfortunately when you go to the link the EiRX is missing, however in the refernces are some names that are part of the framework V grant to study p53 that EiRX belongs to and announced in March 06.

">

Look into my eyes, not round my eyes.


BUY ERX, BUY ERX, BUY ERX

Go up for all of 5 minutes then straight back down.

its scap.. they are short

ERX about to rocket me thinks