About ERIX
EiRx Therapeutics is a specialist provider of pre-clinical therapeutics to the pharmaceutical industry. Our unique scientific expertise and knowledge in the field of Apoptosis provide a sound base to discover and develop new medicines that will safely and selectively repair this natural process in disease. The potential benefits from these new medicines are enormous, since as many as 70% of all human disease have some defect in the control of Apoptosis.
Apoptosis - the biological process that determines whether cells in our bodies live or die...
http://www.eirx.com/index.html

Purchased some of these on the strength of the PROGRESS UPDATE looks promising.
http://moneyam.uk-wire.com/cgi-bin/articles/200603200701130254A.html

ERX interview with John Pool
http://www.wallstreetreporter.com/interview.php?id=18589&player=real
Latest News
CANCER COLLABORATION WITH BIOMERIEUX SA
http://moneyam.uk-wire.com/cgi-bin/articles/200607120700230534G.html
Biomerieux Web Site
http://www.biomerieux.com/servlet/srt/bio/portail/home
ABOUT ERX Focus Of The Month
http://www.billamag.net/focus-document-text.asp?FocusTextID=1
ERX pdf filehttp://www.eirx.com/eirx_heading_images/Yokohama2005.pdf
19/09/2006 A 50% reduction in breast tumour volume size seen with Eirx lead molecule in animal studies
http://moneyam.uk-wire.com/cgi-bin/articles/200609190700171175J.html

Past and present collaborative partners include:

* bioMieux SA
* Almac Diagnostics Ltd
* Merck & Co, Ltd
* Biofocus plc
* MGI Pharmaceuticals, Inc
* OSI Pharmaceuticals, Inc
* Sareum plc
* Regen Therapeutics plc
* SR Pharma plc

the press is wrtting a lot on apoptosis - at the end of the day.. they are all using ERX methods.. so therefore, we are bound to get something. and rather big I would say, after what J Pool said in his interview.. he said very soon and that was back in June, the way the SP has been going it does look soon.. look at all the news out below, its all available on google news, just search Apoptosis


Scientists Identify Compounds That Stimulate Stem Cell Growth In ...
Haber Sağlık, Turkey - 5 hours ago
... absent capacity to divide. When exposed to LXA4, these cells experienced decreased growth and apoptosis. "This study opens doors ...

Harvard scientists report key stem cell research findings
Pharmaceutical Business Review - 9 hours ago
... absent capacity to divide. When exposed to LXA4, these cells experienced decreased growth and apoptosis. "This study opens doors ...

Malignant glioma: engineered adenovirus induces cells to die by ...
Xagena.it, Italy - 14 hours ago
... The cells showed no sign of having been killed by apoptosis. ... Many cancer therapies focus on restoring or enhancing apoptosis to combat the disease. ...

EIRX THERAPEUTICS PLC ORD 0.2P Share Price direct to your mobile ...
Life Style Extra, UK - 17 hours ago
... I would be suprised if eirx had no imput into last weeks announcements regarding the new sucsessful approach to treating cancers, via the apoptosis route, as ...

LB-18, derived from a marine sponge, induces apoptosis in ...
Therapeutics Daily (subscription) (press release), PA - 17 hours ago
... 4 - (NewsRx.com) -- Scientists have isolated a novel synthetic drug, LB-18, from a marine sponge that can induce caspase-independent apoptosis in neuroblastoma ...

Harvard Scientists Report Key Stem Cell Research Findings
International News Service, Australia - 18 hours ago
... absent capacity to divide. When exposed to LXA4, these cells experienced decreased growth and apoptosis. "This study opens doors ...

Breakthrough In The Identity Of Compounds That Encourage Stem Cell ...
MedIndia, India - 18 hours ago
... absent capacity to divide. When exposed to LXA4, these cells experienced decreased growth and apoptosis. "This study opens doors ...

Carbon Monoxide May Prevent Pre-Eclampsia
MedIndia, India - 19 hours ago
... is used, according to Bainbridge et al., who have published a paper called "Carbon monoxide inhibits hypoxia/reoxygenation-induced apoptosis and secondary ...

New hope for patients with lung and joint disease
News-Medical.net, Australia - 23 hours ago
... These drugs trigger a process of cell 'suicide' called apoptosis in which the inflammatory cells, called neutrophils, destroy themselves before being removed ...

Scientists identifiy key compounds that stimulate stem cell growth ...
News-Medical.net, Australia - 4 Sep 2006
... absent capacity to divide. When exposed to LXA4, these cells experienced decreased growth and apoptosis. "This study opens doors ...

patents ERX have a applied for

http://v3.espacenet.com/results?IA=eirx&sf=q&CY=gb&LG=en&DB=EPODOC&st=IA&kw=eirx&Submit=SEARCH&=&=&=&=&=&PGS=10&FIRST=1

Apoptosis!!! ;-)

RESULT LIST
17 results found in the Worldwide database for:
eirx (applicant or inventor)
(Results are sorted by date of upload in database)



1 SCREENING-VERFAHREN in my patents list
Inventor: COTTER TOM (IE); HAYES IAN (IE); (+2) Applicant: EIRX THERAPEUTICS LTD (IE)
EC: G01N33/50D2; G01N33/543K IPC: G01N33/50; G01N33/543; G01N33/50 (+2)
Publication info: AT325889T - 2006-06-15

2 Enzymes involved in apoptosis in my patents list
Inventor: MURPHY FINBARR J (IE); SHEEHAN DYAN E (IE); (+3) Applicant: EIRX THERAPEUTICS LTD
EC: C07K14/47A33 IPC: A61K48/00; A61K38/54; C07K14/47 (+11)
Publication info: US2006121498 - 2006-06-08

3 SCREENING METHOD in my patents list
Inventor: COTTER TOM (IE); HAYES IAN (IE); (+2) Applicant: EIRX THERAPEUTICS LTD (IE)
EC: G01N33/50D2; G01N33/543K IPC: C12Q1/00; G01N33/50; G01N33/543 (+3)
Publication info: DE60119524D - 2006-06-14

4 Human delta-n p73 molecules and uses thereof in my patents list
Inventor: HAYES IAN; LAURENZI VINCENZO DE; (+6) Applicant: EIRX THERAPEUTICS LTD
EC: C07K14/47A1 IPC: C07K14/47; C12N15/12; A61K38/00 (+7)
Publication info: AU2002327945 - 2003-04-01

5 ELAVL-1 in my patents list
Inventor: COTTER TOM (IE); HAYES IAN (IE); (+2) Applicant: EIRX THERAPEUTICS LTD (US)
EC: C07K14/47A33 IPC: C07K14/47; C07K14/435; (IPC1-7): C12Q1/68 (+2)
Publication info: US2005042643 - 2005-02-24

6 Apoptosis-related kinase/GPCRs in my patents list
Inventor: SEERY LIAM (IE); HAYES IAN (IE); (+1) Applicant: EIRX THERAPEUTICS LTD (US)
EC: G01N33/50D2; G01N33/50D2B; (+1) IPC: G01N33/50; G01N33/574; G01N33/50 (+3)
Publication info: US2005019746 - 2005-01-27

7 Apoptosis-related kinase/GPCRs in my patents list
Inventor: SEERY LIAM (IE); HAYES IAN (IE); (+1) Applicant: EIRX THERAPEUTICS LTD (US)
EC: G01N33/50D2; G01N33/50D2B; (+1) IPC: G01N33/50; G01N33/574; G01N33/50 (+2)
Publication info: US2004219616 - 2004-11-04

8 KINASES AND GPCRS INVOLVED IN APOPTOSIS in my patents list
Inventor: SEERY LIAM (IE); HAYES IAN (IE); (+1) Applicant: EIRX THERAPEUTICS LTD (IE); SEERY LIAM (IE); (+2)
EC: G01N33/50D2; G01N33/50D2B; (+1) IPC: G01N33/50; G01N33/574; G01N33/50 (+2)
Publication info: WO2004065959 - 2004-08-05

9 SURVIVIN in my patents list
Inventor: HAYES IAN (IE); COTTER TOM (IE); (+5) Applicant: EIRX THERAPEUTICS LTD (IE); HAYES IAN (IE); (+6)
EC: C07K14/47A1A; C07K14/47A33 IPC: C07K14/47; A61K38/00; C07K14/435 (+2)
Publication info: WO03091384 - 2003-11-06

10 EARLY STAGE REDOX-RELATED APOPTOSIS MODULATOR-2 (ESRAM-2) in my patents list
Inventor: HAYES IAN (IE); COTTER THOMAS (IE); (+2) Applicant: EIRX THERAPEUTICS LTD (IE); HAYES IAN (IE); (+3)
EC: C07K14/47A33 IPC: C07K14/47; A61K38/00; C07K14/435 (+2)
Publication info: WO03054010 - 2003-07-03


11 TGNP in my patents list
Inventor: HAYES IAN (IE); COTTER THOMAS (IE); (+2) Applicant: EIRX THERAPEUTICS LTD (IE); HAYES IAN (IE); (+3)
EC: C07K14/47A33; C12Q1/68M6; (+1) IPC: C07K14/47; C12Q1/68; G01N33/50 (+8)
Publication info: WO03050302 - 2003-06-19

12 P55PIK in my patents list
Inventor: HAYES IAN (IE); COTTER THOMAS (IE); (+2) Applicant: EIRX THERAPEUTICS LTD (IE); HAYES IAN (IE); (+3)
EC: C07K14/47A33; C12N9/12B1B; (+2) IPC: C07K14/47; C12N9/12; C12Q1/68 (+12)
Publication info: WO03048361 - 2003-06-12

13 APOPTOSIS in my patents list
Inventor: HAYES IAN (IE); KROEMER GUIDO (FR); (+2) Applicant: EIRX THERAPEUTICS LTD (IE); INST GUSTAVE ROUSSY L (FR); (+5)
EC: A61K38/46; C12Q1/48B; (+1) IPC: A61K38/46; C12Q1/48; G01N33/68 (+5)
Publication info: WO03027671 - 2003-04-03

14 MODEL SYSTEM in my patents list
Inventor: COTTER TOM (IE); HAYES IAN (IE); (+1) Applicant: EIRX THERAPEUTIC LTD (IE); COTTER TOM (IE); (+2)
EC: C12N15/10C; C12Q1/68P IPC: C12N15/10; C12Q1/68; C12N15/10 (+2)
Publication info: WO0231189 - 2002-04-18

15 SCREENING METHOD 2 in my patents list
Inventor: COTTER TOM (IE); DALY PETER (IE); (+3) Applicant: EIRX THERAPEUTICS LTD (IE); COTTER TOM (IE); (+4)
EC: G01N33/50D2 IPC: G01N33/50; G01N33/50; (IPC1-7): C12Q1/68 (+1)
Publication info: WO0220834 - 2002-03-14

16 Screening method 2 in my patents list
Inventor: COTTER TOM; DALY PETER; (+3) Applicant: EIRX THERAPEUTICS LTD
EC: IPC: C12Q1/68; G01N33/50; C12Q1/68 (+3)
Publication info: AU8426401 - 2002-03-22

17 SCREENING METHOD in my patents list
Inventor: COTTER TOM (IE); HAYES IAN (IE) Applicant: EIRX THERAPEUTICS LTD (IE); COTTER TOM (IE); (+1)
EC: C12Q1/68A6 IPC: C12Q1/68; C12Q1/68; (IPC1-7): C12Q1/68
Publication info: WO0146468

RTTNews) - Gentium S.p.A. (GENT | charts | news | PowerRating) on Tuesday said it would make an oral presentation entitled, "Defibrotide Modulates Immune Functions Of Endothelial Cells - Impact For Transplantation And Cancer Therapy," to show evidence that Defibrotide can protect endothelial cells from conditioning-mediated apoptosis, which suggests that the drug may be used as a prophylactic in patients at risk for endothelial complications. The results will be presented by Gunther Eissner at the 16th European Congress of Immunology on September 7, 2006 in Paris, France.

According to the company, the evidence demonstrates that Defibrotide has anti-inflammatory activity because it prevents transendothelial migration of immune effector cells, and it can reduce the chemotherapy-induced antigenicity of endothelial cells towards allogeneic cytotoxic T lymphocytes. In addition to these endothelium stabilizing functions, recent pre-clinical evidence suggested that Defibrotide has anti-neoplastic properties, which may be due to its ability to prevent tumor angiogenesis. The results demonstrated that Defibrotide reduces blood vessel formation, when administered on a daily basis and also it reduced tumor angiogenesis in the murine dorsal skin fold chamber after inoculation of cells from the human gastric cancer TMK.

ph

Where did you get this info from ?

http://v3.espacenet.com/results?IA=eirx&sf=q&CY=gb&LG=en&DB=EPODOC&st=IA&kw=eirx&Submit=SEARCH&=&=&=&=&=&PGS=10&FIRST=1

http://v3.espacenet.com/results?IA=eirx&sf=q&CY=gb&LG=en&DB=EPODOC&st=IA&kw=eirx&Submit=SEARCH&=&=&=&=&=&PGS=10&FIRST=1

sorry

http://v3.espacenet.com/results?IA=eirx&sf=q&CY=gb&LG=en&DB=EPODOC&st=IA&kw=eirx&Submit=SEARCH&=&=&=&=&=&PGS=10&FIRST=1

ph
thanks will have a read !

there is a lot to read.. but its a darned good read

going to get more at .0017p I hope

PH

I GOT IN AT .24 and was just going to sit and wait as a long term hold,but might buy more if it drops, ??

I know I will, we already know news is around the corner.. its expected this month..

cheeky mm; knocked the price down, they then bought and then whacked the sp right up.. talk about a rip off merchants

Riskypete ... ERXBuy

That's no recommendation, he writes on a bb and uses the same texts as you.

sww

I tend to agree with your first post ! there is a lot of similar research going on .

I don't want to star a fight, but I feel ph is one and the same risky pete.

The bargepole is now in full use.

no.. I am not, I am cannon over at AD fvn .com

Gentium to Present Data Showing Defibrotide Modulates Immune Functions; Endothelial Cell Protection and Anti-angiogenic Activity Has Impact For Transplantation And Cancer Therapy


VILLA GUARDIA (COMO), Italy--(BUSINESS WIRE)--Sept. 5, 2006 - Gentium S.p.A. (NASDAQ:GENT) (the Company) today announced that Gunther Eissner, Ph.D., Department of Hematology, Regensburg University Medical Center, Regensburg, Germany, and Massimo Iacobelli, M.D., Senior Vice President, Scientific Director, Gentium, S.p.A., will make an oral presentation entitled, "Defibrotide Modulates Immune Functions Of Endothelial Cells - Impact For Transplantation And Cancer Therapy," at the 16th European Congress of Immunology. The Congress is being held from September 6-9, 2006 in Paris, France. The presentation will take place on Thursday afternoon, September 7, 2006 in the Immune Interventions Workshop--Immunohematology Track D section in Room 251 at 3:00 p.m. local time.

In their presentation, Drs. Eissner and Iacobelli will show evidence that Defibrotide can protect endothelial cells from conditioning-mediated apoptosis, which suggests that the drug may be used as a prophylactic in patients at risk for endothelial complications. The evidence demonstrates that Defibrotide has anti-inflammatory activity because it prevents transendothelial migration of immune effector cells, and it can reduce the chemotherapy-induced antigenicity of endothelial cells towards allogeneic cytotoxic T lymphocytes.



In addition to these endothelium stabilizing functions, recent pre-clinical evidence suggests that Defibrotide has anti-neoplastic properties, which may be due to its ability to prevent tumor angiogenesis. The anti-angiogenic potential of Defibrotide was tested in vitro using a novel angiogenesis kit (AngioKit(TM)) and in vivo using the dorsal skin fold chamber model in mice. The results demonstrated that Defibrotide at concentrations corresponding to pharmacologic Defibrotide blood levels (100 ug/mL) reduces blood vessel formation significantly (p=0.022), when administered on a daily basis. Furthermore, Defibrotide significantly reduced tumor angiogenesis in the murine dorsal skin fold chamber after inoculation of cells from the human gastric cancer TMK. Regarding the mechanism of action of Defibrotide, initial Western blotting results show that Defibrotide reduces phosphorylation-activation of p70S6 kinase, which is a key target in the PI3K/Akt/mTOR signaling pathway linked to angiogenesis. Additional in vitro data suggest that Defibrotide's action is independent of a blockade of vascular endothelial growth factor (VEGF).

Dr. Laura Ferro, Chairman and Chief Executive Officer of Gentium, commented on the presentation, "The pre-clinical data demonstrate Defibrotide's activity in multiple pathways. Taken together, the data suggest that while Defibrotide is known for its endothelium-protecting function, it also can inhibit blood vessel formation. These data support our clinical strategy to pursue further testing of Defibrotide as an anticancer agent, either as a monotherapy or in combination with other drugs, especially as it appears that it can work synergistically with other VEGF-dependent, anti-angiogenic substances."

About VOD

Veno-occlusive disease (VOD) is a potentially life-threatening condition. Certain high dose chemotherapy and radiation therapies and stem cell transplantation (SCT) can damage cells of the blood vessels and result in VOD, a blockage of the small veins of the liver that can lead to liver failure and the failure of other organs (Severe VOD). SCT is a frequently used treatment following high dose chemotherapy and radiation therapy. The International Bone Marrow Transplant Registry estimated that approximately 45,000 people received blood and bone marrow transplants, which are types of SCT, in 2002. Based on the Company's review of more than 200 published papers, it believes that approximately 20% of patients who undergo SCT develop VOD, approximately one-third of those who develop VOD progress to Severe VOD, and approximately 80% of Severe VOD patients die within 100 days of the SCT. The Company believes that there are no approved therapies to treat or prevent VOD in the U.S. or the EU.

About Gentium

Gentium S.p.A. is a biopharmaceutical company located in Villa Guardia (Como), Italy that is focused on the research, discovery and development of drugs derived from DNA extracted from natural sources, and drugs that are synthetic derivatives, to treat and prevent a variety of vascular diseases and conditions related to cancer and cancer treatments. Defibrotide, the Company's lead product candidate in the U.S., is an investigational drug that has been granted Orphan Drug status by the U.S. FDA to treat Severe VOD and Fast Track designation for the treatment of Severe VOD in recipients of stem cell transplants.

Cautionary Note Regarding Forward-Looking Statements

This press release contains "forward-looking statements." In some cases, you can identify these statements by forward-looking words such as "may," "might," "will," "should," "expect," "plan," "anticipate," "believe," "estimate," "predict," "potential" or "continue," the negative of these terms and other comparable terminology. These statements are not historical facts but instead represent the Company's belief regarding future results, many of which, by their nature, are inherently uncertain and outside the Company's control. It is possible that actual results may differ, possibly materially, from those anticipated in these forward-looking statements. For a discussion of some of the risks and important factors that could affect future results, see the discussion in our Form 20F filed with the Securities and Exchange Commission under the caption "Risk Factors."

I bet we are at this meeting in paris

DRUGS IN DEVELOPMENT



EpiCept Announces Results of European Phase III Trial for LidoPAIN SP



ENGLEWOOD CLIFFS, N.J., Sept. 5, 2006 /PRNewswire-FirstCall/ -- EpiCept Corporation announced today that LidoPAIN(R) SP, a sterile prescription analgesic patch designed to provide sustained topical delivery of lidocaine to a post-surgical or post-traumatic sutured wound, did not meet its co-primary endpoints in a Phase III clinical trial in Europe.




The Phase III clinical trial was a randomized, double-blind, placebo-controlled trial of 440 patients who underwent hernia repair surgery. The trial results indicate that LidoPAIN SP did not achieve a statistically significant effect relative to placebo with respect to the primary endpoint of self-assessed pain intensity between 4 and 24 hours. In addition, a statistically significant effect was not achieved in the trial's co-primary endpoint of patient use of "rescue" medications, i.e. systemically-delivered analgesics used to alleviate pain.

The Company's initial analysis of the trial data indicates that the total amount of pain from 4-24 hours as measured by the area under the curve (AUC) had a p value of approximately 0.4; the co-primary endpoint of rescue medication use from hours 4-24 had a p value of approximately 0.09. Both treatment groups showed an analgesic effect with the greater analgesic response in the active group. The product was well tolerated in all treatment groups.

Jack Talley, President and Chief Executive Officer, stated, "We are obviously disappointed that LidoPAIN SP did not meet its co-primary endpoints, particularly in light of the positive results achieved by the product candidate in its Phase II trial. We will in particular be looking at changes which occurred in going from Phase II to Phase III. A thorough analysis of the trial results has been initiated and our findings will serve as the basis for our decision on next steps for this product candidate. As this analysis proceeds, we remain focused on continuing to advance our other late-stage pain and cancer product candidates in our pipeline, each of which target significant unmet medical needs. Notably, we remain on schedule to file our Marketing Authorization Application for Ceplene for Acute Myeloid Leukemia in Europe later this year, we are in the final stages of preparing our IND filing for EPC2407 a novel apoptosis inducer for certain types of cancer and we are continuing to scale up manufacturing for EpiCept NP-1 and LidoPAIN BP in anticipation of the initiation of pivotal trials."

About Ceplene(TM)

Ceplene is a registration-stage compound for the treatment of Acute Myeloid Leukemia (AML) as remission maintenance therapy. AML is the most common type of leukemia in adults, with an estimated 30,000 AML patients in the U.S. and an estimated 47,000 patients in the EU. There are currently no approved remission drug therapies for AML patients.

EpiCept is currently preparing a Marketing Authorization Application (MAA) in Europe for Ceplene. This MAA is expected to be filed in the fourth quarter of 2006. The basis of this application will be the results of a 320 patient Phase III clinical study, in which Ceplene met its primary endpoint of increased leukemia-free survival among AML patients in remission. Ceplene has been granted orphan drug status for the treatment of AML by the European Medicines Agency (EMEA).

About EpiCept(TM) NP-1

EpiCept NP-1 is a prescription topical analgesic cream designed to provide effective, long-term relief from the pain of peripheral neuropathies. Peripheral neuropathies are medical conditions caused by damage to the nerves in the peripheral nervous system. It is estimated that these conditions affect more than 15 million people in the U.S. alone and is associated with conditions that injure peripheral nerves, including herpes zoster, or shingles, diabetes, HIV and AIDS and other diseases. It can also be caused by trauma or may result from surgical procedures.

EpiCept has successfully completed Phase II clinical trials in the U.S. and Canada for EpiCept NP-1, which included 343 subjects. The Company is in the process of scaling up the production of NP-1 to prepare for the product candidate's Phase III clinical trials, which are scheduled to commence at the end of 2006. The initial planned indication for this product candidate is post-herpetic neuralgia, a specific type of peripheral neuropathy associated with shingles.

About LidoPAIN(R) BP

LidoPAIN BP is a prescription analgesic non-sterile patch designed to provide sustained topical delivery of lidocaine for the treatment of acute or recurrent lower back pain of moderate severity of less than three months duration. The LidoPAIN BP patch is intended to be applied once daily and can be worn for a continuous 24-hour period. The patch's adhesive is strong enough to permit a patient to move and conduct normal daily activities, but can be removed easily.

EpiCept has completed Phase II clinical trials in the U.S. for LidoPAIN BP. EpiCept is currently working towards scaling up production of this product candidate in order to commence Phase III clinical trials. These trials will be conducted in close consultation with Endo Pharmaceuticals, which is EpiCept's partner for the commercialization of LidoPAIN BP worldwide.

Conference Call

EpiCept will host a conference call to discuss the LidoPAIN SP trial results on September 6, 2006 at 8:30 AM EDT. To participate, please dial 888-243-6208 from the U.S. or Canada or 973-582-2869 from international locations (please reference access code 7834338).

About EpiCept Corporation

EpiCept is an emerging specialty pharmaceutical company focused on unmet needs in the treatment of pain and cancer. The Company has a staged portfolio of product candidates with several pain therapies in late-stage clinical trials, and a lead oncology compound (for AML) with demonstrated efficacy in a Phase III trial; the compound is intended for commercialization in Europe. EpiCept is based in New Jersey, and the Company's research and development team in San Diego is pursuing a drug discovery program focused on novel approaches to apoptosis.