Thought Id start this one going because its rather dead on this board at the moment and I suppose all my usual muckers are either at the Stella tennis event watching Dim Tim (lose again) or at Henly Regatta eating cucumber sandwiches (they wish,...NOT).

Anyway please feel free to just talk to yourself blast away and let it go on any company or subject you wish. Just wish Id thought of this one before.

cheers GF.

Overindulged?

Hmmm? Hope is at hand....

Tiny tummy patch could cut fat by one third in four weeks...without exercise



Prof Chen Peng (left) holding the drug-laden microneedle fat burning patch with Asst Prof Xu Chenjie CREDIT: NANYANG TECHNOLOGICAL UNIVERSITY

Telegraph. Sarah Knapton, science editor
29 DECEMBER 2017 • 2:53PM
For those who have overindulged during the Christmas period help may be at hand from scientists in Singapore.

A tiny tummy patch has been shown to cut body fat by 30 per cent in just 28 days without the need to exercise.

The patch is covered in hundreds of microneedles which are smaller than a human hair and gradually supply a dose of two weight-loss drugs.

The drug combination works to transform stubborn white fat into more manageable brown fat, which is burned away as energy by the body to keep warm.

Although the patch has so far only been tested in animals, scientists at the Nanyang Technological University (NTU) want to move to human trials quickly, and have already received interest from several biotech companies who are keen to develop the device.

It is estimated that two thirds of Britons - 36 million - will be overweight of obese by 2025 and weight gain is a risk factor for many health problems, including diabetes, heart disease, stroke and some cancers.

But scientists believe the patch, which costs around £2.50 to make, could help people who struggle to lose weight, without needing to resort to costly surgery.

“What we aim to develop is a painless patch that everyone could use easily, which is unobtrusive and yet affordable,” said Prof Chen Peng, a biotechnology and obesity expert at NTU.

“Most importantly, our solution aims to use a person’s own body fats to burn more energy, which is a natural process in babies.”

The patch delivers the diet drug ‘Beta-3 adrenergic receptor agonist’ and a thyroid hormone called ‘T3 triiodothyronine’ which is a commonly used for medication for an underactive thyroid gland.

When the patch is pressed into the skin for about two minutes, the micro-needles become embedded and the patch can then be removed.

As the needles degrade, the drug molecules slowly make their way to the energy-storing white fat underneath the skin layer, turning it into energy-burning brown fat.

Brown fats are found in babies and they help to keep the baby warm by burning energy. As humans grow older, the amount of brown fats lessens and is replaced with white fats, which are stored and are difficult to remove.

Experiments in mice, which were fed on a high-fat diet, showed that the patch reduced their fat mass by more than 30 percent over a period of just four weeks. It also significantly lowered their blood cholesterol and levels of fatty acid.

Two thirds of Britons will be overweight or obese by 2025, according to estimates
Two thirds of Britons will be overweight or obese by 2025, according to estimates CREDIT: CHRIS RADBURN PA
Assistant Professor Xu Chenjie of NTU, added: “With the embedded microneedles in the skin of the mice, the surrounding fats started browning in five days, which helped to increase the energy expenditure of the mice, leading to a reduction in body fat gain.

“The amount of drugs we used in the patch is much less than those used in oral medication or an injected dose. This lowers the drug ingredient costs while our slow-release design minimises its side effects.”

Obesity and diabetes combined already costs the UK more than £5 billion each year and is likely to rise to £50 billion by 2050 according to the World Obesity Federation.

Professor Melvin Leow, of NTU, added: “These data should encourage Phase I Clinical studies in humans to translate these basic science findings to the bedside, with the hope that these microneedle patches may be developed into an established cost-effective method for the prevention or treatment of obesity in the near future.”

The research was published in the journal Small Methods.

a good massage with snakeoil is invaluable .... medical science has proved it

Aye getting off your fat arse and taking some exercise also works. (Not to put tooo fine a point on it) :o)

Could do with a truck load of those here in the valleys.

I honestly feel physically sick , Glegg somehow has received a Knighthood , good god is there nothing we can do , it's beyond anything .

Eamonn Holmes services to broadcasting , don't they realise these people get paid and waited on hand and foot . It's just sick .

Is there anything in life that you're happy with, Victim? Just curious.

A bit harsh there i think just my opinion you know , you must be easily pleased or just trying to be funny .

I just have to say how upset I am about Nick Clegg and Ringo Starr getting knighthoods.

Ringo spends his life living between California and Switzerland and, I would suspect, most likely doesn't even pay UK taxes. So a good example there? NOT.

Nick Clegg is famous for promising to slash student fees and then tripling them - and not much else. I can't even believe he is a Tory crony. He had previously declined any position in the Lords which he wanted to abolish. Maybe his knighthood makes up for him not going up to the H of L.

There are a few people out there who should have been given awards, IMHO. Most blatantly, people like Nigel Farage, who did an absolutely fantastic job explaining the negatives of the EU to us all. So much so, that he was probably the most influential person in creating the national Brexit vote. I just cannot believe how he has been snubbed by the higher Tory establishment. His comments about the awards system tell it just exactly how it is. I think it needs abolishing altogether if it produces the crap awards results like Ringo and Nick Clegg.

Roll on the time when Theresa May steps down and Jacob Rees-Mogg steps up.

Victim,

If I scroll through your recent posts, I see rants at Fred, complaints about the EU, moans about remoaners, moans about social media users, negative comments on Mickey Owen, and then some. And now you're unhappy because folks have received New Year honours who, apparently, haven't done anything of merit to deserve those honours.

I just figured it might be easier if you told us what it is in life that you are happy with, rather than leaving us all to guess at random.

Morning, hilary.

Please knock Ringo off his skis for me, if you see him on the slopes. ;-)

Nigel Farage led a party of ranting geriatrics who could only get one parliamentary seat, and that was through a Tory defection to UKIP. He was too much of a liability to lead the Leave campaign, and should probably be shot for treason rather than knighted.

And Jacob Rees-Mogg? Well he's just a moronic dinosaur who will never lead the Tories, never become PM, and never be knighted.

There's light rain in the Gateway to the Sun this morning, Doc. That's why I'm here to wind you lot up.

:o)

So what , just put me on ignore , if i scroll through your posts i see a person with a mighty big ego coming across as superior to all others that post on here , until someone corrects you , if you think i care . Ha ha , bluddy hilarious .

Why would I want to squelch you now I know which buttons to press?

Hils

Well, we are all entitled to our opinion on JR-M.

I just like how he puts out his points of view with a simple 'easy to understand clarity' and with exceptionally good oratory. And, 'Yes', he is a bit quirky. I don't like his 'moronic stance' on rape and abortion which he justifies with and from his catholicism base. But there again, I'm an atheist. As I say, he is entitled to his opinions. That particular one is very strong with him and he is entitled to it. I rationalise how he uses this one to show everyone, that he has an exceedingly strong personal morality.

I'm not alone in liking him. Amongst those who really count, he has topped the poll for at least the last two months on 'Conservativehome.com' for who they would like to see as the next Tory Leader:

https://www.conservativehome.com/thetorydiary/2017/12/our-survey-next-tory-leader-as-last-month-rees-mogg-leads-and-gove-is-second.html

I see JR-M is also their 'Parliamentarian of the Year':

https://www.conservativehome.com/thetorydiary/2017/12/our-panels-conservative-parliamentarian-of-the-year-is-can-you-guess.html

Aaargh! I see Gove comes second in their 'next Tory leader' poll. I now have cognitive dissonance on it! The pollsters must be dick-heads! :-)

JR-M ....... moronic he most certainly is not, and if you bother to listen to him, he's actually very amusing ...... i think i'ld rather JR-M over BJ as PM, though i very much hope that is not a choice we'ld need to make

I didn't say he was moronic, cynic.

I said, that IMHO, he has a moronic stance on rape and abortion.

And I do agree, that JR-M has an almost fascinating and amusing ability to clearly communicate on his many points.

IMHO: Since 'Rape' is a crime, when committed, how can a crime be used as a sensible basis on which to make further decisions about what the victim should or should not do about her pregnancy? Particularly, even moral ones, such as on the religious rights and wrongs of abortion. There are so many factors to take into consideration - and with regard to both parties in the rape act, too.

This is not the dark ages any more. A termination can be done with exceptional care for the patient whose fetus does not yet even have any consciousness - and so is not yet even 'alive' in the true sense of the word. ie. if the fetus is not yet alive then its 'life' will not get destroyed. Only its 'potential for life' will be destroyed with a pregnancy termination. But there again....Who am I to say? It's just my opinion.

Remind me again the names of Rees-Mogg's children, and then tell me that's the working of somebody sound of mind.

PS.

Slave owners had strong personal moralities and vied for the best seats when they went to church on Sundays, but didn't care a damn on a Monday.