after yesterdays agm statement the share price has risen 50% how much upside is left or is this another false dawn?
http://www.alexa.com/data/details/traffic_details/thewellnessshop.co.uk
womans hour link below.
http://www.bbc.co.uk/radio4/womanshour/04/2008_08_mon.shtml

Beating the Blues feature investigating the value of CBT for depression.
Available on the BBC's listen again to original broadcast.

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mcmahons thanks for above,i have put the link in the header

Percent Change +3.14% today woodie sould be a good week next week .want be here to see it ..off on sunday back following week i try to log on sure you want miss me ,with all that money coming your way...............;-))

I bought these at 2.2 and surprised myself by hanging on this long when I should have cut my losses and waited. Quite frankly right now I would consider myself very lucky to break even lol

micky have a nice time, it will only be paper money until i sell,gb you never know it might get back up to your buy price.
agm tuesday i would be suprised if there is no new news issued then.

Hmmmm no position here, ex owner having sold out at 4p level (i know seems like a long time ago!) but the rally, although welcome to owners, is not a steady consolidating rise, beware the spike...

woodie i'm in profit in a big way..... no ball shit but i'm here for the long i belive we can see 5p/10p+ but depends on the news coming out next week there should be news from USA. monday.AMG tuseday SP friday haaaaaaaaaaaaammmmm....looking froward to it..............;-))

micky cant see news on monday with agm tuesday might be wrong though

would be nice .......still can't have it all ..have a nice weekend ........spk soon

have a good time take care

.

if any news i expect it will be tommorrow at the agm

Antidepressant drugs don't work official study




Change font size: A | A | ABy Jeremy Laurance, Health Editor
Tuesday, 26 February 2008


They are among the biggest-selling drugs of all time, the "happiness pills" that supposedly lift the moods of those who suffer depression and are taken by millions of people in the UK every year.


But one of the largest studies of modern antidepressant drugs has found that they have no clinically significant effect. In other words, they don't work.

The finding will send shock waves through the medical profession and patients and raises serious questions about the regulation of the multinational pharmaceutical industry, which was accused yesterday of withholding data on the drugs.

It also came as Alan Johnson, the Health Secretary, announced that 3,600 therapists are to be trained during the next three years to provide nationwide access through the GP service to "talking treatments" for depression, instead of drugs, in a 170m scheme. The popularity of the new generation of antidepressants, which include the best known brands Prozac and Seroxat, soared after they were launched in the late 1980s, heavily promoted by drug companies as safer and leading to fewer side-effects than the older tricyclic antidepressants.

The publication in 1994 of Listening to Prozac by Peter Kramer, in which he suggested anyone with too little "joy juice" might give themselves a dose of the "mood brightener" Prozac , lifted sales into the stratosphere.

In the UK, an estimated 3.5 million people take the drugs, collectively known as selective serotonin reuptake inhibitors (SSRIs), in any one year and 29 million prescriptions were issued in 2004. Prozac, the best known of the SSRIs made by Eli Lilly, was the world's fastest-selling drug until it was overtaken by Viagra.

In the study, researchers conducted a meta-analysis of all 47 clinical trials, published and unpublished, submitted to the Food and Drug Administration in the US, made in support of licensing applications for six of the best known antidepressant drugs, including Prozac, Seroxat which is made by GlaxoSmithKline and Efexor made by Wyeth. The results showed the drugs were effective only in a very small group of the most extremely depressed.

Two drugs were excluded from the study because of incomplete data. A third drug, chemical name nafazodone, has been withdrawn from the market because of side-effects.

Professor Irving Kirsch of the University of Hull, who led the study published in the online journal Public Library of Science (PLoS) Medicine , said the data submitted to the FDA would also have been submitted to the licensing authorities in Britain and Europe. It showed the drugs produced a "very small" improvement compared with placebo of two points on the 51-point Hamilton depression scale.

That was sufficient to grant the drugs a licence but did not meet the minimum three-point difference required by the National Institute for Clinical Excellence (Nice) to establish "clinical" significance. Yet Nice approved the drugs for use on the NHS in the UK because it only had access to the published trials, which showed a larger effect.

Professor Kirsch said: "Given these results, there seems to be little reason to prescribe antidepressant medication to any but the most severely depressed patients, unless alternative treatments have failed to provide a benefit. This study raises serious issues that need to be addressed surrounding drug licensing and how drug trial data is reported."

Five years ago, there were allegations that antidepressant drugs were addictive and could trigger suicides. All but Prozac were banned for children, although a major investigation on the safety of medicines cleared them of causing suicide in adults.

Alternative treatments for depression, such as counselling or physical exercise , should be tried first, Professor Kirsch said. The pharmaceutical companies had withheld data that was available to the licensing authorities so that doctors and patients did not understand the true efficacy, or lack of it, of the drugs.

"This has been the frustration. It has made it very difficult to answer the question of whether the drugs work. The pharmaceutical companies should be obliged when they get a drug licensed to make all the data available to the public. When you analyse all the trials of these SSRIs, both published and unpublished, it leads you to more sober conclusions," he said.

Tim Kendall, deputy director of the Royal College of Psychiatrists' research unit, said the findings, if proved true, would not be surprising. As head of the National Collaborating Centre for Nice guidelines on mental health, he said it had proved impossible to get access to unpublished trials in the past.

"The companies have this data but they will not release it. When we were drawing up the guidelines on prescribing antidepressants to children [in 2004] we wrote to all the companies asking for it but they said no. The Government pledged in its manifesto to compel the drug companies to give access to their data but that commitment has not been met."

The new finding would make doctors "much more cautious about prescribing the drugs," Mr Kendall added.

GlaxoSmithKline, makers of Seroxat, said the authors of the study had "failed to acknowledge" the very positive benefits of SSRIs and their conclusions were "at odds with the very positive benefits seen in actual clinical practice." A spokesperson added: "This one study should not be used to cause unnecessary alarm for patients.

Lilly said in a statement: "Extensive scientific and medical experience has demonstrated that fluoxetine [Prozac] is an effective antidepressant.

Wyeth said: "We recognise the need for both pharmacological and non-pharmacological treatments for depression."

On the new training for therapists, Mr Johnson said the programme signalled a decisive shift away from drugs in favour of non-drug treatments for depression. "We are not taking the decision away from clinicians," he said.

"For many, medication is successful. But talking therapies can have dramatic effects. We have put a lot of emphasis on medication in the past and it is about time we redressed the balance and put more emphasis on talking treatments."

The treatments that do work

* Exercise: Helps some people with depression. Douglas Adams, author of The Hitchhiker's Guide to the Galaxy, said running helped him cope with depression.

* Friends: Talking through your feelings can help in mild depression with a friend or relative or in a self-help group.

* Cognitive behavioural therapy: Teaches you to challenge negative thoughts and feelings of hopelessness.

* Interpersonal therapy: Focuses on relationships and problems such as difficulties with communication.

* Counselling: Helps you think about the problems in your life and find new ways of dealing with them.

* Antidepressants: Increasingly seen as a second-line treatment, if exercise or talking treatments do not work.

Ultrasis PLC
26 February 2008


Press release 26th February 2008



Ultrasis plc



Oldham PCT takes pole position in BTB delivery



The first PCT in the country to implement NICE Guidance in full by agreeing
delivery of 'Beating the Blues' for the next 3 years



Ultrasis plc, the provider of interactive healthcare and associated services, is
pleased to announce that Oldham Primary Care Trust ('PCT') has signed a three
year contract to provide its flagship product Beating the Blues ('BtB').



The three year agreement has a value in excess of 150,000, and means Oldham PCT
has commissioned sufficient capacity of the NICE approved treatment program for
depression to meet this binding obligation in full, through 100 per cent
compliance.



John Smith, Ultrasis' Executive Director, said: 'This is a great example of how
the National Framework Agreement, negotiated on behalf of the Department of
Health by the NHS Purchasing and Supply Agency can benefit the commissioning
process and enable PCTs to get maximum benefit for their patients. This contract
clearly demonstrates the growing confidence of PCTs in commissioning Beating the
Blues to deliver improved access to psychological therapies.'



- ends -

Woodie
On top of good News Oldham PCT.
See antidepressant drugs don't work official study - GMTV this morning.

micky you are missing the fun today!
elbow that is linked to my first post today it is in most of the dailys,it was also on bbc breakfast at 6.30.

you early birds !

elbow the more coverage re anti-depresaants dont work the better.who was on gmtv? bbc had md of mind on paul farmer

Dr Hillary their usual dude on GMTV.
Not seen press yet or BBC item.
Coverage is certainly getting hotter.

http://www.independent.co.uk/life-style/health-and-wellbeing/health-news/antidepressant-drugs-udontu-work-ndash-official-study-787264.html