Does anyone have an opinion on PRM.
No comparable news for a while.
Price seems to be sliding once again.

Couple of broker research notes out in recent weeks.

House broker Landsbanki has a target price of 62p, but they don't include upfronts or back-dated royalties from the expected TMT deal.

Blue Oar Securities have a much higher target of 150p, but with a few assumptions including TMT signing fees and receipt of upfront payments. These would cover royalties from companies currently in infringement of Proteome's patent position.

Last guidance from the company suggested early 08 for the all-important TMT deal. Let's face it they haven't exactly got a glowing track record on delivery versus past guidance, so the market is still very much in 'wait and see' mode (as it seems to have been pretty much for ever!)

Upside is substantial IF they can finally deliver. Further down the line, hostile takeover remains a viable option for those wishing to acquire the isobaric mass tag technology (rather than licence in).

Thanks bluemango.
just seem to be waiting on the never/never. am still waiting on Alzeimers news.there doesnt seem to be any further update on licensing etc.
will have to keep on waiting.looks like the very long haul.

Disagree that it will be a further long haul. Even Pearce doesn't have infinite patience and he will now be looking for a return on his substantial stake in the company just like the rest of us. The take-up of TMT technology is also likely to be rapid according to market projections. Blue Oar wouldn't have given a 150p target if they saw this as years away. This is their current risk adjusted SOTP valuation, dependent only on the company signing the TMT deal, with Alzheimer's etc to come later.

Yes it's been a very long wait, but that doesn't necessarily mean it will continue to be. Far too many observers of this stock fall into the trap of simply extrapolating from past performance, rather than looking at the situation as it is today and the likely outcomes.

I am told from my reliably informed city source that a major announcement is only a matter of days and not weeks away..legal side of tying up matters has caused delay so far but not for much longer!..LOL on the way..patience will be rewarded!

Despite no news yet, we must be getting alot closer to the big "A" which will bring cheer to all who have held this long....should hear within next month definitely i am reassured!..time to consider topping up at these levels...38/40p!

After your post 5 you should have a "red face"!!

Can't say there's anything unrealistic about what blueface is saying. It only agrees broadly with what the company have been saying themselves, after all.

BIG "A" ANNOUNCED AT 18.03...!!!

It will be interesting to see what value is placed on this deal - - - it had better be good, eh?

I hold from some while ago and frankly, any excitement has long since gone.

Well,the big announcement has came and went.
Lots of sells,but also a lot of buys.

Hopefully will end the week above the 50p mark.

What is the licence worth in revenue terms?

Landsbanki have said in their brief up to date note that the Thermo Fisher deal would "conservatively" add another 24p to their original target price of 62p earlier this year.
They add that the royalties to PRM would be equivalent of 20% of sales on which PRM would be making a gross margin of 80%- which net TMT-based income could be "double their conservative estimates",etc.
They also mention that the challenge which had been lodged to its European TMT patent suggets that the Thermo believes the patent is secure.
I am reliably informed that the company will be making some further announcements in coming weeks..LOL for the everlasting patient shareholders!

Thermo Fisher will be rolling out Proteome's TMT(R)Tags at the 56th ASMS Conference on Mass Spectrometry and Applied Topics in Denver, USA from June 1st to 5th next week ...this will prove to be very interesting to see what the feedback will be !!..hopefully very positive in which case PRM shares are a steal still at current level of 39/40p!!...BUY..LOL will be on the way soon!

Another red day.No news seems to be the norm these days.Am still patiently waiting.Has anybody any information on the Alzheimers licence,it seems to have been put on the wayside for the moment.

21% down to c. 26p= = = = wow, what a waster!

Despite there being "good news soon" - something that's been "in the post..." for the last six years to my memory we investors have seen nothing. The Management of this co couldnt sell vinegar at a fish and chip convention.
. . . . . . . . . . . . . . The facts speak for themselves. . . . . . . . . . . . .
Er, Whatever they have, no-one wants .....at the price PRM wants to do a deal - that is if anyone needs a deal; for Life has gone on (on this planet) for millions of years without PRM's markers....and I guess it will continue that way...
expect 20p soon, as they will be wanting more cash to keep this beast rolling.
EDIT 01Aug08
Company expectations appear to have improved (heard that before!) with an Ann expected soon. However, as is common in small AIM-stocks no-one knows (what/ when /How-much, etc.) - so maybe we won't see 20p - more like 40p as this bears market-hallmarks of having reached its bottom.

I predict a BIG ANNOUNCEMENT soon

Market Reaction in last two days seems to indicate something coming VERY SOON.

Something's going on for sure - two lots of Price Monitoring Extensions on Thurs and Fri of this week, and sp shot up. Just can't think what's going on as I've not followed this for a while, though did notice the rise in last couple of days. Think I may leap back on board first thing Monday.

... on second thoughts: sp is indicating down this morning. Will keep an eye on it

No obvious NEWs yet - so what caused the big rise ( almost doubled!).?
Maybe a perception that this technology has some merit and will be big one day. Maybe it's a better understanding of the Dir-Loan (being in Shareholder interest?) and so on.
Without solid news this could slip back as folk depart, taking a small profit as is tempting.....or do you hang-on in there to reaqp the potential rewards?

This Co has always told the Market there is a Big-Deal round the corner...and maybe one day there will be.
What's odd, is that with a technology so good - why aren't Drug-Co's snapping them up? . . . . . . that remains a worry, but IF there is a good deal - then this should multiply - I have a small holding from c. sub30p and somewhat more higher...I guess I might be near-evens currently, but if it goes well, I shall be happy enough.
Current Markets strip-out losers....just hope this survives OK.

I'm not feeding this one....waiting will do.

"What's odd, is that with a technology so good - why aren't Drug-Co's snapping them up?"

The director loan and its current terms involving the IP and potential conversion are in effect a 'poison pill' for any would-be predator. CJP's game-plan will probably involve an agreed takeover at some future time, but not before full value has been added. The two main cash inflows still to come are, firstly, sub-licences from current infringers of the TMT patents thus allowing TF and PRM to tap into current/future royalty streams, plus a large element for back-royalties due to PRM. Secondly they are still pursuing a 30m euros warranties claim with Sanofi-Aventis. Both could result in multi-million windfall payments to Proteome, and may be a motivation behind some of the recent buying.

This is all quite apart from possible commercial deals for HTS biomarkers and for Alzheimer's biomarkers.

Nothing new in the above of course, which is why the Company still have something of a credibility hill to climb. So until any of the above actually occur, there's still an element of gamble here, but with corporate activity involving ABI this Autumn, the odds are at last looking to shift in Proteome's favour.

Bluemango, yes I agree about that loan - yet the story from the company was started nearly ten years ago - so why didn't any Big Pharma want it then?....mainly punters bought shares . . . and that was the start of their/our woes.

Seems to me that many large-Co's don't look to their furture. By watching nascent technologies they might be able to ride the wave well into the future. No, I'm not suggesting a buy-out, just a "initerest" with maybe some assistance by way of Management expertise...

So, let's hope it is starting to come true, eh?

Big pharma tend to be ultra-cautious and move at absolute snail pace. They certainly wouldn't have risked resources on unproven technology ten years ago, particularly bearing in mind this would have been before PRM acquired the rights to the TMT technology via Xzillion.

Now, they are also still unlikely to make a move while, in theory, the patent situation is on the face of it unclear with an ABI objection to PRM's patent still outstanding. However the key to movement here will be EPO clarification of the patent situation (unless Invitrogen/ABI decide to settle beforehand) and with Thermo Fisher then obtaining a license from ABI - with back-royalties due to PRM dating back to 2004.

This Patent-issue is a worry, that after so long we discover there is a broken patio-door round the back of the castle. Tad careless, or is this "claim" opportunistic I wonder. This is unlikely since no professionals would associate themselves with a trivial claim, so I suspect it has some merit, however small. This will drag on the shares, although this morming they are up on "no-news".
We'll just have to wait a lot longer, I fear.

Such Pessimism from the pair of you. I say the pair of you because this has to be one of the least used boards on the Proteome saga. I have only held shares for a relitely short period of their history but have held long enough to see them swing from 45p down to 18 or so then right back up to 42 recently. All the while wishing I had a crystal ball to take advantage of what for some was a 100% gain within around two weeks.
I hear what your saying Hangon regarding the patent issue but lets not forget that Thermo Fisher came on board already knowing that ABI were challenging again. I think I am correct in saying again as I believe Proteome has already won in court regarding the Patents once. This challenge is little different from the first lost case for ABI and this I believe is why Thermo Fisher are happy to be on board before the result of what they can only judge to be another win for Proteome. These people have the best legal advice possible and they would have done there own extensive research into the possibilities of loosing this challenge. It seems like mere/sour grapes stalling tactics on ABI's behalf.
As Bluemango suggested, it may get settled beforehand to avoid more costs than already mounting. At the time ABI didn't know that Thermo Fisher was going to go on board with proteome and may have thought that a long drawn out challenge could have seen the back of Proteome or a buy out. Just my thoughts.
I think the next six months will bare fruit...how much in this insanely turbulent market is anybodies guess. Good news these days can see a healthy days gain only to be forgotten and lost a few days after for no other reason than blind panic selling or "market conditions" ! A lovely saying for those companies with little to do with any of the recent problems seeing their value slide away as if they were the cause of it.....I'm not bitter !!! :o) Obe2

Obe2konobi , Yes I think much of what you say about the Legal issue could be true - "opportunism" -
However, this dismisses the key issue that they are always supposed to be "near" a deal yet even with Fisher there seems to be Great Silence.

My understanding is that "proetomics" give a clear indication to the correct drug-treatment; explaining variations in patients taking the same stuff, etc. so why isn't this Red-Hot? [EDIT:-However, I'm wondering if it has the ability to create more information than is good for us - for example a pH-test gives a colour and you compare this agqainst a chart. If however you put the test-strip into a machine which prints out the whole works of shakespere (as it were), you have more work to do and a lot more time is wasted, etc.].
Think of the money the NHS spends; which by correct "targeting" the effects could double, say ....and it should be evident the NHS requires half the drugs, since they don't give patients the "wrong stuff".
However, I'm not sure that PRM is "yet" at this simplistic stage, rather like in the early days of photography, B&W is nice but colour would be better, then along come PRM with a process that gives you colour - except they only have yellow.......very exciting I don't think....and until PRM manages to convey what it's got ( to shareholders) they will be stuck in this yo-yo region, drifting now because of the general-woes.

And still there is silence . . . just how long do shareholders have to wait for some return? . . . . . Grr.

EDIT -(18Jn09)-Oh deary, result out and sp falls . . . . you have to wonder at the patience of shareholders in this kingdom.

I think they need to empty the fridges in the executive suite wherever they sleep.
(that's where the smell is)
Good to read that Share-Options are still considered part of Exec. pay . . . . . . .........Grr.
(This stock has lost 2/3 value since 2007 - DYOR -) - 24p mid today on small trades, nearly even despite a 10% push by MM's.
EDIT (20Nov2010)- SP has risen, presumably a few months of no bad News - we needed it!, now 36p-ish DYOR.
EDIT (11Feb2011) -slipped to 34p after a rise, due to Jan Contract win.
EDIT (5Sept2013)-; Yawn,- Peaked 70p 2013 now dn at 46p . . . oh deary, how dreary . . .
((EDIT))Dec2016...Looking back 10years - easily 90% Club - it's now 5.5p

Thought I'd post again . . . but nowt to say - this Co. is a thorough disappointment.
27p-ish
EDIT Jan2017 - now about 5p. . . . hopeless.

Some good news today and rising from a very low point now 42.25p

28 June 2013 AGM

Proteome Sciences expects a sharp increase in group revenue in 2013, the company's annual general meeting statement says.

The group says its commercial activities are benefiting from its technology development and the rapid increase in the numbers of biomarkers covered by its assays that doubled to over 100 in 2012.

It says SysQuant cell signalling pathway assays introduced this year will extend these further and should make a considerable contribution to the assay portfolio. This is reflected in biomarker services in revenue particularly through the major strategic contract announced earlier this month and through a broad and growing pipeline of contracts, enquiries and quotations.

Proteome Sciences says licensing discussions are expected to benefit from the excellent results coming through this year from CK1D that will be presented at the main Alzheimer's meeting in July, strongly supported by the considerable improvement in performance from two new peptide panels announced in the preliminary results for Alzheimer's disease and mild cognitive impairment (MCI), with further developments anticipated from our stroke biomarkers.

Outstanding data was presented at the June ASMS meeting using TMT which now appears to be established as the reagent of choice for key opinion leaders in the field. The growing range of products and applications should accelerate and convert more widely the use of TMT into mainstream biology and additional revenue. Proteome Sciences says it has again been made aware of certain speculative and inappropriate comments regarding its US biomarker patent portfolio in the light of recent US court rulings on patent eligibility, in particular the court's recent ruling against Myriad that patents will not be allowed on genes.

Proteome Sciences says this has no bearing on the company's intellectual property.

And it says shareholders will be pleased to know that the company received subsequent notification this week from the US Patent and Trademark Office of the allowance of a new patent in Huntington's disease.

It adds: "We conclude that these decisions do not change the status of our issued and pending US applications or impact our granted US patents which continue to remain in good standing.

"We expect a strong performance over the year from licences, products and services as we continue to raise our corporate and research profile and this should lead to a sharp increase in Group revenue in 2013."

I have gone grey waiting for the sharp rise in revenue to beat the even sharper rise in losses!

It seems that Alzheimers could be detected 10 years before the symptoms appear if suitable biomarkers are employed. I gather that the Government are keen to fund the
work as ,although there is no cure yet available,the dementia can be largely mitigated
if found soon enough.Cameron has just doubled the grants available.I had to look after my father for 6 years of dementia and I really hope I am not going down that road.
I am back in.

What would be the point of detecting Az 10 years beforehand? - And how do they know? Surely the body is so complex you could die of something else and then the detection would be - pointless. Of course if it was cheap, then maybe - but I don't know the price-point of these "markers" - and I suspect they aren't cheap.
Anyone know?

The trouble with this co (investment) appears to be that investors never benefit from all this good medicine. As to Government being keen - I discount this as Political posturing - otherwise they'd be spending money - but the mantra of NHS is to Cut, Cut, Cut - so I don't see where PRM is going to get acceptable income from UK/NHS.
This co. is a serial disappointment IMHO.
EDIT: (25March2014)...35p &+ve movement, but recent ( Feb14), Placing at 28p was a further blow to earlier investors. I see CP has bought 4m shares since 2008.
EDIT (Oct2014) Looks like Mr Diggle likes this company as well as OXB - appears to have LT investment for his Life-Sciences fund....DYOR. sp now 31p
EDIT ( 20Jan2015 ) NHS cuts cancer-drug funding for patients, PRM sp 25p
EDIT (31March2015)- earlier iin March more agreements signed-plus US Patent granted -DYOR- sp is 19p - Oh deary..... where's the money?
EDIT (2June2015 )-Oh deary, looks like 2014-Sales barely £1m and losses stack up to £60m - DYOR - looks pretty thin for Investor returns.... yet-awhile.
EDIT-(24May2016)- New CEO for June16 maybe reverse fortune...fell 9% to 17p.
EDIT(1Nov2016)-Bad Summer. PRM rose today to 6p. Oh deary.
EDIT(2Nov2016) -£3.2m@5p Rights-Huh- Why the slide is now revealed. It's 22% dilution-The timescale appears rushed... Anyone?
EDIT(30Dec2016)-Big Ann re Website - pres wh they've been spending investor money and PRM-management effort . . . www.proteomics.com. - does not work...Error msg 404 . . . what a waste of effort.... Wake Up PRM to the real World - and earn us some money from the trust we placed. sp 5.5p
EDIT (24April2017)- missed the AGM, because they don't send the paperwork any more . . . must have known it would be of little interest, etc. sp 5.5 could be worse? - at lest theior website is OK, but no mention of AGM, yesterday.
EDIT (30May2017)- sp down today (on small Vulpes Investment buy?) = 4.8p
EDIT (25July2017) - sp down 17% ( now 3.72p ). Management thinks results are in line...etc. Loss this time is 50k better than last. Oh dear.
EDIT (28July2017)-sp 3.6p...... Half-year results RNS [DYOR]:- T/O (similar to large corner-shop ), is smaller than losses, again - does no-one want this stuff?
EDIT:(7Nov2017)_ I mean their Testing-kits...or whatever..... BUT, there is the issue...as I find it difficult to say exactly "What" they are trying to sell.... Oh Dear.
Makes you want to weep, eh?
EDIT (6Jan2018)- down on Results, 2p8 - doesn't look good at all.

Listen: Proteome Science (PRM) - Preliminary results

Click here to listen

EDIT ( 18April2018) - RNS=extended agreement with subsidiary of ThermoFisherInc - but clearly the income from these deals is close to zippo... ( with current sp about 3p...DYOR.) . Relying on one Sales outlet is BAD News, as it makes you vulnerable to takeover at low price.....Oh and that's where we are.. .Oops! All IMHO.
EDIT (3May2018)- sp still ~3p - note that Martin Diggle has bought 100,000 shares DYOR towards end of 2017 - but no-one else believes this Co is going anywhere. I don't like reliance on one major outlet . . . surely if the stuff's good every Medic will want it?
EDIT(6Dec2018)- sp 3.55 (down 8%)...\ Co. News is Dir buying earlier in 2018. No chance this business will pick up. BTW they sell testing stuff for others to make Drug Discoveries - seems like they need a Division to develop something like..... . . ? Instead of waiting for Others - and who are these others?