Hutchison China MediTech Limited ("Chi-Med") is a China-based globally-focused healthcare group which researches, develops, manufactures and sells pharmaceuticals and health-related consumer products.

Its Innovation Platform focuses on discovering and developing innovative therapeutics in oncology and autoimmune diseases for the global market. Its Commercial Platform manufactures, markets and distributes prescription drugs and consumer health products in China.

Chi-Med is listed on the London Stock Exchange’s AIM market (AIM: HCM). It is majority owned by CK Hutchison Holdings Limited (SEHK: 0001), a leading international conglomerate committed to innovation and technology with over a quarter of a million employees in more than 50 countries and annual sales of over US$50 billion.

http://www.chi-med.com/eng/global/home.php

Lilly Deal for Fruquintinib

RNS


RNS Number : 0695Q

Hutchison China Meditech Limited

09 October 2013












Hutchison China MediTech Limited ("Chi-Med")

(AIM: HCM)





Cancer Therapy Collaboration with Lilly





London: Wednesday, 9 October 2013: Hutchison MediPharma Limited ("HMP"), an R&D company majority owned by Chi-Med, today announces that it has entered into a licensing, co-development, and commercialisation agreement in China with Eli Lilly and Company ("Lilly") for Fruquintinib (HMPL-013), a targeted oncology therapy for the potential treatment of various types of solid tumours. Fruquintinib, a selective inhibitor of the Vascular Endothelial Growth Factor ("VEGF") receptor tyrosine kinases, was discovered by HMP and is currently in Phase II testing in China.



Under the terms of the agreement, the costs of future development of Fruquintinib in China, to be carried out by HMP, will be shared between HMP and Lilly. HMP will potentially receive a series of payments of up to US$86.5 million, including upfront payments and development and regulatory approval milestones. Should Fruquintinib be successfully commercialised in China, HMP would receive tiered royalties starting in the mid-teens percentage of net sales. Additional terms of the agreement were not disclosed.



Christian Hogg, Chief Executive Officer of Chi-Med said: "Our belief is that Fruquintinib has potential activity against multiple tumour types with high incidence rates and may benefit patients with significant unmet medical needs in China. The collaboration with Lilly will allow for Fruquintinib to be developed across various tumour types in China and at a far greater speed than if we went alone."



"We are excited to collaborate with Hutchison MediPharma in the development of this potential new cancer therapy," said Jacques Tapiero, Lilly Senior Vice President and President of Emerging Markets. "In Lilly's emerging markets business, we are focused on providing patients with innovative medicines from our own pipeline and through collaborations with respected science-based companies such as HMP. Together, we are committed to help meet the medical needs of oncology patients in China."



Ends

Payment From Janssen Pharmaceuticals

RNS


RNS Number : 0697Q

Hutchison China Meditech Limited

09 October 2013


Hutchison China MediTech Limited ("Chi-Med")

(AIM: HCM)


Candidate Nomination of Novel Small-Molecule Therapy in Inflammation Triggers Milestone Payment From Janssen Pharmaceuticals, Inc.



London: Wednesday, 9 October 2013: Chi-Med today announces that Hutchison MediPharma Limited ("HMP"), its majority owned R&D company, is set to receive a milestone payment of US$6 million from Janssen Pharmaceuticals, Inc. ("Janssen"), pursuant to the global strategic alliance (the "Agreement") to develop novel small-molecule therapeutics against a target in the area of inflammation/immunology entered into by the companies in June 2010.

The US$6 million milestone was triggered by a compound, the Candidate, discovered by HMP in collaboration with Janssen meeting certain development candidate criteria pursuant to the Agreement. Upon achievement of specific clinical development and approval milestones, HMP may potentially receive up to an additional US$90.5 million and is entitled to royalties on worldwide sales upon commercialisation of a product by Janssen.



Ends

Director/PDMR Shareholding

RNS


RNS Number : 6600Q

Hutchison China Meditech Limited

16 October 2013












Hutchison China MediTech Limited ("Chi-Med")

(AIM: HCM)





Director's Shareholding





London: Wednesday, 16 October 2013: Chi-Med received notification on 16 October 2013 that Ms Edith Shih, Non-executive Director and Company Secretary of Chi-Med, purchased 20,000 ordinary shares of US$1.00 each in Chi-Med (the "Shares") at a price of GBP6.20 each on 15 October 2013.



Following this purchase, Ms Shih is beneficially interested in 20,000 Shares, representing approximately 0.04% of the current issued share capital of Chi-Med.





Ends

IC this week - Shares in the Chinese drug developer, which is part of the giant Hong Kong based conglomerate Huchison Whampoa, have gained 25% over the past 12 months after an important deal with Swiss company Nestle to co-develop plant derived medicine HPML- 004 for gastric treatment. The drug is currently undergoing extensive phase lll clinical trials that will report sometime in mid 2014. The biotech research division also has at least five oncology products in its pipeline that are currently at the phase I stage of development. In addition, there is also an extensive Chinese medicine business which analysts value at around £247m . The company also earned a £3m milestone from Janssen Pharmaceuticals as part of an agreement to develop novel inflammation/immunology medicines.


But the major news flow in 2014 will be in connection with the Nestle joint venture and analysts will wait for this before revising their forecasts.

In Shares - Mark Slater manager of MFM Slater growth. Less well understood , are the rich property assets on the balance sheet and the progress being made by Chi-Med's majority owned research and development company , a biotechnology arm he describes as being 'years ahead of the next best Chinese R&D business'.
' I think the shares could double from here quite easily', says Slater.

IC this week continue to rate the shares a buy. Game changer, aim company with 10 bagger innovations.

In IGI this week - Mark Slater Boasting a 'huge pipeline of products' 'I think the shares could double from here quite easily'.

Sinopharm distribution joint venture in China

RNS


RNS Number : 8467V

Hutchison China Meditech Limited

18 December 2013












Hutchison China MediTech Limited ("Chi-Med")

(AIM: HCM)





Chi-Med and Sinopharm form China drug distribution and marketing joint venture





London: Wednesday, 18 December 2013: Chi-Med, the pharmaceutical and healthcare company based primarily in China, today announces the establishment of a new joint venture with Sinopharm Group Co. Ltd. ("Sinopharm"). Sinopharm is the largest distributor of pharmaceutical and healthcare products and a leading value added supply chain service provider in China. The joint venture will provide distribution and marketing services to both related and third party pharmaceutical companies in China.



Chi-Med will, through a wholly-owned subsidiary, invest approximately US$9.8 million in cash into Sinopharm Holding HuYong Pharmaceutical (Shanghai) Co., Ltd. ("Huyong") for the subscription of 51% of the equity in the enlarged share capital of Huyong, which will mean that Huyong will be consolidated as a Chi-Med subsidiary. The Chi-Med investment will be largely deployed for expanding future commercial activities, particularly in the area of third party drug sales and marketing. Sinopharm will hold the balance of 49% of the equity in Huyong.



Huyong is a Good Supply Practice ("GSP") certified pharmaceutical and healthcare distribution and marketing company that was originally established in 1993 and subsequently acquired by Sinopharm in 2010. Huyong will be renamed as Hutchison Whampoa Sinopharm Pharmaceuticals (Shanghai) Company Limited ("Hutchison Sinopharm"). Huyong's profit before tax for the year ended 31 December 2012 was US$1.0 million, and had gross assets at 31 December 2012 of US$29.9 million.



Hutchison Sinopharm will be reported under the China Healthcare Division of Chi-Med which currently comprises three companies: Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Company Limited ("HBYS"); Shanghai Hutchison Pharmaceuticals Limited ("SHPL"); and Hutchison Healthcare Limited ("HHL"). The 2012 sales of the China Healthcare Division subsidiaries and jointly controlled entities of Chi-Med were US$350.5 million and net profit attributable to Chi-Med equity holders was US$15.5 million.



Hutchison Sinopharm will provide a platform for synergy across the China Healthcare Division of Chi-Med by utilising the services of the approximately 2,800-person prescription drug and over-the-counter drug sales teams of SHPL and HBYS. A major aspect of the Hutchison Sinopharm business strategy will be to provide sales, distribution, and marketing services to major domestic and multi-national third party pharmaceutical manufacturers. It will also provide a broadened sales and marketing platform for HHL's products and potentially the future novel drugs registered by Hutchison MediPharma Limited, Chi-Med's Drug R&D Division.



This transaction is subject to regulatory approval in China.



Christian Hogg, Chi-Med CEO said: "This strategic investment widens the scope of our China Healthcare Division dramatically by allowing Chi-Med's commercial organisation to market third party pharmaceutical products. We are honoured to partner with Sinopharm in the area of drug distribution and marketing and expect to build a material business based on the complementary strengths of our two groups over the coming years."

Notice of Results

RNS


RNS Number : 6998X

Hutchison China Meditech Limited

16 January 2014














Hutchison China MediTech Limited ("Chi-Med")

(AIM: HCM)





Notice of Announcement of 2013 Final Results





London: Thursday, 16 January 2014: Chi-Med will be announcing its final results for the year ended 31 December 2013 on Tuesday, 18 February 2014. An analyst presentation will be held at 9:00am on the same day at Panmure Gordon, 3rd Floor, One New Change, London, EC4M 9AF.





Ends

Final Results

RNS


RNS Number : 2681A

Hutchison China Meditech Limited

18 February 2014














Hutchison China MediTech Limited ("Chi-Med")

(AIM: HCM)



Final Results for the year ended 31 December 2013

Continued momentum. Continued very considerable growth potential.



London: Tuesday, 18 February 2014: Chi-Med today announces its final results for the year ended 31 December 2013.



Consolidated Group Results (IFRS11)

· Revenue from continuing operations up 106% to $46.0 million (2012: $22.4m), not including sales at the JV level which totalled $390.6 million (2012: $345.3m).

· Operating profit up 65% to $9.6 million (2012: $5.8m) including non-recurring charge of $2.0 million.

· Net profit attributable to Chi-Med equity holders up 63% to $5.9million (2012: $3.6m).

· Cash and cash equivalents at the Chi-Med Group level of $46.9 million (31 December 2012: $30.8m) in addition, and not included at the Group level, cash and cash equivalents held at the JV level totalled $99.0 million (31 December 2012: $62.4m).



Results are reported in US dollar currency unless otherwise stated.



Christian Hogg, Chi-Med CEO, said: "Chi-Med has had a highly successful 2013. We have propelled our revenues and profit, and the drivers of this success are set to continue.



Our Drug R&D Division has taken a major step forward by signing a new licensing deal with Eli Lilly and cementing its collaboration with Janssen to add to those it already has with AstraZeneca and Nestlé Health Science. Its revenues have increased sharply due to payments from these partners. It has significantly progressed its six clinical stage drug candidates either reaching, or closing in on, proof-of-concept. We have spent over $30 million on clinical trials in 2013, with our partners funding the great majority of these clinical costs. Several of our compounds in clinical development showed impressive results in 2013 - in two cases for treatment of certain tumour types, for which there are few, if any, treatment options approved on the global market.



By the end of 2013, Chi-Med had received $72 million of upfront and milestone payments and equity injections from our four partners. Looking ahead, this cash flow should escalate. In addition to funding the vast majority of clinical costs on our partnered drug candidates, our partners will contribute, subject to clinical success, up to approximately $1.2 billion in development, approval, and commercial milestones and option payments, as well as customary royalties on net sales.



Our China Healthcare Division continues to grow rapidly with net profit attributable to Chi-Med equity holders up 20% in 2013, again demonstrating the major potential in the China pharmaceutical market. Its sales and profitability are now benefitting from the normalisation of raw material prices and, this year, we hope to start crystallising the value in our manufacturing property portfolio. To take advantage of the opportunity for Chi-Med to provide sales, distribution and marketing services to major Chinese and multi-national third party pharmaceutical manufacturers as well as our own Drug R&D Division, we have formed a joint venture with Sinopharm.



Our Consumer Products Division grew sales 23%, driven by the progress of Hutchison Hain Organic, while Sen France and aspects of our China infant formula businesses have been discontinued.



Trading has started well this year. Sales and profit in our China Healthcare Division are well ahead of 2013 levels, as a result of effective execution and continued normalisation of raw material costs. We expect 2014 to be a breakout year for our Drug R&D Division as we publish clinical data on Volitinib, Fruquintinib and Sulfatinib, in each case outlining next stage clinical plans. On HMPL-004 we will reach our Interim Analysis on NATRUL-3, our Phase III induction study, and publish status in mid-2014. We expect also to start Phase I trials on our spleen tyrosine kinase ("Syk") inhibitor for inflammation in Australia, which would elevate the profile of this very high potential programme. Our Consumer Products Division's continuing operations have started well and we expect the refocused operations to be profitable this year.



The opportunities facing us are very considerable and we believe we will deliver further substantial shareholder value this year and beyond."



Highlights

China Healthcare Division - Continuing strong growth

· Sales of subsidiaries and joint ventures ("JVs") up 13% to $394.6 million (2012: $350.5m). Organic expansion of own brands (up 14% to $343.0m) with both prescription and over-the-counter ("OTC") cardiovascular drug sales being the strongest. Third party OTC drug distribution business up only 2% to $51.6 million due to shedding of lower margin activity.

· Net profit attributable to Chi-Med equity holders up 20% to $18.6 million (2012: $15.5m).

· Entered into an agreement to establish a new 51% Chi-Med owned JV, subject to regulatory approval, with Sinopharm Group Co. Ltd. (HKSE:1099) ("Sinopharm") to provide sales, distribution, and marketing services to major Chinese and multi-national third party pharmaceutical manufacturers.



Drug R&D Division - Step-change developments approaching

· Revenue up 327% to $29.5 million (2012: $6.9m) as a result of $22.2 million in upfront and milestone income and $7.3 million in service income from our partners.

· Secured $54.8 million in third party cash injections for Hutchison MediPharma Limited's ("HMP") activities during 2013, bringing the total to $103.6 million since 2010.

· Net lossattributable to Chi-Med equity holders of $2.4 million (2012: net profit $2.8m) due primarily to the consolidation of $8.8 million (2012: nil) non-cash share of the loss of Nutrition Science Partners Limited ("NSP"), the JV with Nestlé Health Science SA ("Nestlé Health Science"). NSP, which is enrolling patients in the HMPL-004 global Phase III registration trial, was entirely self-funded in 2013, and will be until the Interim Analysis in mid-2014, by the initial cash equity investment in NSP by Nestlé Health Science.

· Progressed global development of Volitinib (HMPL-504), a c-Met inhibitor in oncology, in partnership with AstraZeneca AB (publ) ("AstraZeneca") in Phase I in Australia and China. Phase I dose escalation, initiation of which triggered a $5 million milestone in mid-2013, will be completed by early 2014 and results will be published at the American Society of Clinical Oncology ("ASCO") meetings in June 2014. Volitinib has demonstrated very encouraging anti-tumour activity in Phase I in certain tumour-types, some of which have no approved therapies on the global market. Phase II studies in papillary renal cell carcinoma ("PRCC") will start in early 2014 in the United States and global Phase III initiation is scheduled for 2015.

· Completed exclusive license and collaboration agreement for China with Eli Lilly and Company ("Lilly") on Fruquintinib (HMPL-013), our highly selective vascular endothelial growth factor receptor ("VEGFR") inhibitor. Lilly will share development costs and pay HMP up to $86.5 million in upfront payments and development and regulatory milestones and upon commercialisation in China tiered royalties starting in the mid-teens percentage of net sales. Fruquintinib, which received Phase II/III clearance from the China Food & Drug Administration ("CFDA") in mid-2013, will start Phase II studies in several tumour types, and a Phase III registration study on one tumour type, in China in 2014.

· Immunology collaboration with Janssen Pharmaceuticals, Inc. ("Janssen"), the pharmaceutical division of Johnson & Johnson, progressed well in 2013. Janssen nominated a compound, HMPL-507, discovered by HMP, for further development thereby triggering a $6 million milestone payment. Janssen will be responsible for all development costs and will potentially pay HMP up to an additional $90.5 million in development and regulatory approval milestones, and royalties on worldwide sales upon commercialisation.

· Beyond the four partnered drug candidates, HMP has effectively progressed three further high potential small molecule oncology drug candidates with stand-out results on Sulfatinib which in 2013 demonstrated very encouraging anti-tumour activity in certain tumour types, some of which have very limited treatment options approved on the global market.

· In discovery, HMP nominated HMPL-523 in early 2013, a novel Syk inhibitor, for rheumatoid arthritis and intends to start Phase I trials in Australia in early 2014.



Consumer Products Division - Refocused

· Sales on continuing operations up 23% to $12.5 million (2012: $10.2m) driven by progress on the expansion of the range of Hutchison Hain Organic Holdings Limited ("HHO") products in Asia.

· Non-recurring $2.0 million in costs associated with the discontinuation of the Sen France and aspects of the China infant formula businesses.

· Net loss attributable to Chi-Med equity holders on continuing operations of $0.5 million (2012: -$0.9m).



Group results are reported for the full year for the first time under IFRS11 "Joint Arrangements" ("IFRS11"), which establishes the equity accounting principle for the reporting of JVs and means that the income statements and statements of financial position of JVs will no longer be proportionately consolidated. However, total revenues of the JVs will continue to be disclosed throughout the announcement.



A presentation for analysts will be held at 9:00 a.m. today at the offices of Panmure Gordon at 3rd Floor, One New Change, London EC4M 9AF.

The Annual General Meeting of Chi-Med will be held at 4th Floor, Hutchison House, 5 Hester Road, Battersea, London SW11 4AN on Thursday, 8 May 2014 at 10:00 a.m.



Ends

Hutchison China MediTech Ltd (HCM:LSE) set a new 52-week high during today's trading session when it reached 735.00. Over this period, the share price is up 67.05%.

A buy in last weeks IC

Doing very well since the new year.

Edison - Valuation: Increased to $791m (932p a share)
Updating our sum-of-the-parts model for the FY13 results and the progress in the R&D pipeline sees our valuation rising from $577m (705p a share) to $791m (932p a share) – ex property windfalls. MediPharma is valued, using an rNPV, at $257m (303p a share); placing China Healthcare on a peer group rating gives $505m (595p per share); with Consumer Products adding $36m (42p a share). Netting out group net cash/debt results in our $791m (932p a share) value.

Hutchison China MediTech Ltd (HCM:LSE) set a new 52-week high during today's trading session when it reached 900.00. Over this period, the share price is up 104.55%.

Really Taken off in March, a new high.

Hutchison China MediTech Ltd (HCM:LSE) set a new 52-week high during today's trading session when it reached 973.00. Over this period, the share price is up 121.14%.

Shares - has stated that Huchison MediTech Ltd in the coming months is poised to close a number of deals. In the light of the Chinese newsflow it demands caution.

Hutchison China MediTech: UBS raises target price from 820p to 1000p, but downgrades from buy to neutral.

Hutchison China Meditech: Panmure Gordon increases target price from 750p to 950p and stays with its buy recommendation.