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IN BRIEF: Syncona’s Freeline gets positive results for Gaucher disease

ALN

Syncona Ltd on Thursday - London-based investor in healthcare companies - Says UK portfolio company Freeline Therapeutics Ltd presents positive new data from its phase I and II Galileo-1 study of FLT201, its novel gene therapy candidate, in Gaucher disease. Says FLT201 demonstrates a favourable safety and tolerability profile, with no infusion reactions and no severe adverse events. Syncona notes that Gaucher disease is a ‘debilitating genetic disorder caused by a deficiency of the GCase enzyme’. Syncona Chief Executive Officer Chris Hollowood says: ‘We are very encouraged by the data generated from FLT201 which demonstrates a favourable safety and tolerability profile and significant enzyme activity. We are confident this treatment has the potential to challenge the standard of care in Gaucher disease, where current treatments are life-long and do not fully alleviate the disease.’ Freeline Therapeutics is based in Stevenage, Hertfordshire.

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